Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TUTLB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TUTLB_HUMAN
GO:0000166 nucleotide binding 60.0000 4 no
GO:0004713 protein tyrosine kinase activity 60.0000 4 no
GO:0004715 non-membrane spanning protein tyrosine kinase activity 60.0000 5 no
GO:0005524 ATP binding 60.0000 5 no
GO:0016301 kinase activity 60.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 60.0000 4 no
GO:0017076 purine nucleotide binding 60.0000 5 no
GO:0030554 adenyl nucleotide binding 60.0000 6 no
GO:0032555 purine ribonucleotide binding 60.0000 4 no
GO:0032559 adenyl ribonucleotide binding 60.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 60.0000 4 no
GO:0043168 anion binding 60.0000 4 no
GO:0046875 ephrin receptor binding 40.0000 4 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 40.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in TUTLB_HUMAN
GO:0001932 regulation of protein phosphorylation 80.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 80.0000 8 no
GO:0009893 positive regulation of metabolic process 80.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 80.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 80.0000 5 no
GO:0019220 regulation of phosphate metabolic process 80.0000 6 no
GO:0031323 regulation of cellular metabolic process 80.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 80.0000 5 no
GO:0031399 regulation of protein modification process 80.0000 6 no
GO:0031401 positive regulation of protein modification process 80.0000 7 no
GO:0042325 regulation of phosphorylation 80.0000 7 no
GO:0042327 positive regulation of phosphorylation 80.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 80.0000 7 no
GO:0048522 positive regulation of cellular process 80.0000 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 80.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 80.0000 9 no
GO:0051174 regulation of phosphorus metabolic process 80.0000 5 no
GO:0051246 regulation of protein metabolic process 80.0000 5 no
GO:0051247 positive regulation of protein metabolic process 80.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 80.0000 4 no
GO:0080090 regulation of primary metabolic process 80.0000 4 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 60.0000 4 no
GO:0002431 Fc receptor mediated stimulatory signaling pathway 60.0000 5 no
GO:0002683 negative regulation of immune system process 60.0000 4 no
GO:0002684 positive regulation of immune system process 60.0000 4 no
GO:0002694 regulation of leukocyte activation 60.0000 4 no
GO:0002696 positive regulation of leukocyte activation 60.0000 5 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 60.0000 4 no
GO:0002861 regulation of inflammatory response to antigenic stimulus 60.0000 5 no
GO:0002862 negative regulation of inflammatory response to antigenic stimulus 60.0000 6 no
GO:0006796 phosphate-containing compound metabolic process 60.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 60.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 60.0000 5 no
GO:0009889 regulation of biosynthetic process 60.0000 4 no
GO:0009892 negative regulation of metabolic process 60.0000 4 no
GO:0010468 regulation of gene expression 60.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 60.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 60.0000 5 no
GO:0016310 phosphorylation 60.0000 5 no
GO:0022407 regulation of cell-cell adhesion 60.0000 5 no
GO:0022409 positive regulation of cell-cell adhesion 60.0000 6 no
GO:0030155 regulation of cell adhesion 60.0000 4 no
GO:0030334 regulation of cell migration 60.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 60.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 60.0000 5 no
GO:0031344 regulation of cell projection organization 60.0000 5 no
GO:0031347 regulation of defense response 60.0000 5 no
GO:0031348 negative regulation of defense response 60.0000 5 no
GO:0032101 regulation of response to external stimulus 60.0000 4 no
GO:0032102 negative regulation of response to external stimulus 60.0000 5 no
GO:0033993 response to lipid 60.0000 4 no
GO:0036211 protein modification process 60.0000 4 no
GO:0038093 Fc receptor signaling pathway 60.0000 5 no
GO:0038094 Fc-gamma receptor signaling pathway 60.0000 6 no
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 60.0000 4 no
GO:0043085 positive regulation of catalytic activity 60.0000 4 no
GO:0043086 negative regulation of catalytic activity 60.0000 4 no
GO:0043412 macromolecule modification 60.0000 4 no
GO:0043549 regulation of kinase activity 60.0000 5 no
GO:0045785 positive regulation of cell adhesion 60.0000 5 no
GO:0045859 regulation of protein kinase activity 60.0000 6 no
GO:0048013 ephrin receptor signaling pathway 60.0000 6 no
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0048584 positive regulation of response to stimulus 60.0000 4 no
GO:0048585 negative regulation of response to stimulus 60.0000 4 no
GO:0050727 regulation of inflammatory response 60.0000 5 no
GO:0050728 negative regulation of inflammatory response 60.0000 6 no
GO:0050776 regulation of immune response 60.0000 4 no
GO:0050777 negative regulation of immune response 60.0000 5 no
GO:0050778 positive regulation of immune response 60.0000 5 no
GO:0050863 regulation of T cell activation 60.0000 6 no
GO:0050865 regulation of cell activation 60.0000 4 no
GO:0050867 positive regulation of cell activation 60.0000 5 no
GO:0050870 positive regulation of T cell activation 60.0000 7 no
GO:0051049 regulation of transport 60.0000 4 no
GO:0051128 regulation of cellular component organization 60.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 60.0000 4 no
GO:0051248 negative regulation of protein metabolic process 60.0000 6 no
GO:0051249 regulation of lymphocyte activation 60.0000 5 no
GO:0051251 positive regulation of lymphocyte activation 60.0000 6 no
GO:0051338 regulation of transferase activity 60.0000 4 no
GO:0051348 negative regulation of transferase activity 60.0000 5 no
GO:0071310 cellular response to organic substance 60.0000 4 no
GO:0071396 cellular response to lipid 60.0000 5 no
GO:0080134 regulation of response to stress 60.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 60.0000 6 no
GO:0140546 defense response to symbiont 60.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 60.0000 4 no
GO:1903037 regulation of leukocyte cell-cell adhesion 60.0000 6 no
GO:1903039 positive regulation of leukocyte cell-cell adhesion 60.0000 7 no
GO:2000145 regulation of cell motility 60.0000 4 no
GO:0001817 regulation of cytokine production 40.0000 4 no
GO:0001933 negative regulation of protein phosphorylation 40.0000 8 no
GO:0002220 innate immune response activating cell surface receptor signaling pathway 40.0000 5 no
GO:0002223 stimulatory C-type lectin receptor signaling pathway 40.0000 5 no
GO:0002758 innate immune response-activating signaling pathway 40.0000 4 no
GO:0002831 regulation of response to biotic stimulus 40.0000 4 no
GO:0002833 positive regulation of response to biotic stimulus 40.0000 5 no
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0006469 negative regulation of protein kinase activity 40.0000 7 no
GO:0008284 positive regulation of cell population proliferation 40.0000 5 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0009967 positive regulation of signal transduction 40.0000 5 no
GO:0009968 negative regulation of signal transduction 40.0000 5 no
GO:0010243 response to organonitrogen compound 40.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 40.0000 6 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0010648 negative regulation of cell communication 40.0000 5 no
GO:0010975 regulation of neuron projection development 40.0000 7 no
GO:0014070 response to organic cyclic compound 40.0000 4 no
GO:0018108 peptidyl-tyrosine phosphorylation 40.0000 6 no
GO:0018193 peptidyl-amino acid modification 40.0000 5 no
GO:0018212 peptidyl-tyrosine modification 40.0000 6 no
GO:0019221 cytokine-mediated signaling pathway 40.0000 4 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0023057 negative regulation of signaling 40.0000 4 no
GO:0030162 regulation of proteolysis 40.0000 6 no
GO:0030335 positive regulation of cell migration 40.0000 6 no
GO:0031346 positive regulation of cell projection organization 40.0000 6 no
GO:0031349 positive regulation of defense response 40.0000 5 no
GO:0031400 negative regulation of protein modification process 40.0000 7 no
GO:0032103 positive regulation of response to external stimulus 40.0000 5 no
GO:0032526 response to retinoic acid 40.0000 4 no
GO:0032868 response to insulin 40.0000 5 no
GO:0033673 negative regulation of kinase activity 40.0000 6 no
GO:0034762 regulation of transmembrane transport 40.0000 4 no
GO:0040017 positive regulation of locomotion 40.0000 4 no
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0042326 negative regulation of phosphorylation 40.0000 8 no
GO:0042981 regulation of apoptotic process 40.0000 5 no
GO:0043065 positive regulation of apoptotic process 40.0000 6 no
GO:0043067 regulation of programmed cell death 40.0000 4 no
GO:0043068 positive regulation of programmed cell death 40.0000 5 no
GO:0043408 regulation of MAPK cascade 40.0000 6 no
GO:0043434 response to peptide hormone 40.0000 4 no
GO:0045088 regulation of innate immune response 40.0000 5 no
GO:0045089 positive regulation of innate immune response 40.0000 6 no
GO:0045862 positive regulation of proteolysis 40.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 40.0000 7 no
GO:0046777 protein autophosphorylation 40.0000 6 no
GO:0046903 secretion 40.0000 4 no
GO:0051094 positive regulation of developmental process 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051336 regulation of hydrolase activity 40.0000 4 no
GO:0052547 regulation of peptidase activity 40.0000 5 no
GO:0052548 regulation of endopeptidase activity 40.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 40.0000 4 no
GO:0062207 regulation of pattern recognition receptor signaling pathway 40.0000 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 40.0000 7 no
GO:0071300 cellular response to retinoic acid 40.0000 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 40.0000 7 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:1902532 negative regulation of intracellular signal transduction 40.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 40.0000 6 no
GO:1990858 cellular response to lectin 40.0000 4 no
GO:2000147 positive regulation of cell motility 40.0000 5 no
GO:0003018 vascular process in circulatory system 40.0000 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0036119 response to platelet-derived growth factor 40.0000 4 no
GO:0036120 cellular response to platelet-derived growth factor stimulus 40.0000 5 no
GO:0071363 cellular response to growth factor stimulus 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0007010 cytoskeleton organization 40.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 40.0000 4 no
GO:0033674 positive regulation of kinase activity 40.0000 6 no
GO:0034446 substrate adhesion-dependent cell spreading 40.0000 4 no
GO:0045860 positive regulation of protein kinase activity 40.0000 7 no
GO:0051347 positive regulation of transferase activity 40.0000 5 no
GO:0061097 regulation of protein tyrosine kinase activity 40.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 40.0000 8 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
YAP1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
MKRN1_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
TEC_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes