Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLPP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5-phosphate (PNP) and pyridoxamine 5-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed, PubMed). Also functions as a protein serine phosphatase that specifically dephosphorylates Ser-3 in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLPP_HUMAN
GO:0042803 protein homodimerization activity 50.0000 4 yes
GO:0046872 metal ion binding 50.0000 4 yes
GO:0000287 magnesium ion binding 37.5000 5 yes
GO:0005524 ATP binding 37.5000 5 no
GO:0017076 purine nucleotide binding 37.5000 4 no
GO:0030554 adenyl nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0031625 ubiquitin protein ligase binding 37.5000 5 no
GO:0044389 ubiquitin-like protein ligase binding 37.5000 4 no
GO:0004722 protein serine/threonine phosphatase activity 25.0000 4 yes
GO:0016791 phosphatase activity 25.0000 5 yes
GO:0033883 pyridoxal phosphatase activity 25.0000 6 yes
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 yes
GO:0043136 glycerol-3-phosphatase activity 25.0000 6 yes
GO:0046914 transition metal ion binding 25.0000 5 no
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0002020 protease binding 25.0000 4 no
GO:0008017 microtubule binding 25.0000 5 no
GO:0015631 tubulin binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PLPP_HUMAN
GO:0051128 regulation of cellular component organization 87.5000 4 yes
GO:0022607 cellular component assembly 75.0000 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0051130 positive regulation of cellular component organization 62.5000 5 yes
GO:1901565 organonitrogen compound catabolic process 62.5000 4 yes
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:0097435 supramolecular fiber organization 50.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006767 water-soluble vitamin metabolic process 37.5000 4 yes
GO:0007015 actin filament organization 37.5000 5 yes
GO:0010564 regulation of cell cycle process 37.5000 5 yes
GO:0019439 aromatic compound catabolic process 37.5000 4 yes
GO:0032465 regulation of cytokinesis 37.5000 5 yes
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0042816 vitamin B6 metabolic process 37.5000 5 yes
GO:0042822 pyridoxal phosphate metabolic process 37.5000 4 yes
GO:0044270 cellular nitrogen compound catabolic process 37.5000 4 yes
GO:0046434 organophosphate catabolic process 37.5000 4 yes
GO:0046700 heterocycle catabolic process 37.5000 4 yes
GO:0051017 actin filament bundle assembly 37.5000 5 yes
GO:0051302 regulation of cell division 37.5000 4 yes
GO:0051493 regulation of cytoskeleton organization 37.5000 6 yes
GO:0051726 regulation of cell cycle 37.5000 4 yes
GO:0061572 actin filament bundle organization 37.5000 6 yes
GO:0071310 cellular response to organic substance 37.5000 4 yes
GO:0071417 cellular response to organonitrogen compound 37.5000 4 yes
GO:0072524 pyridine-containing compound metabolic process 37.5000 4 yes
GO:1901361 organic cyclic compound catabolic process 37.5000 4 yes
GO:1901699 cellular response to nitrogen compound 37.5000 4 yes
GO:0018130 heterocycle biosynthetic process 37.5000 4 no
GO:0019438 aromatic compound biosynthetic process 37.5000 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 37.5000 4 no
GO:1901362 organic cyclic compound biosynthetic process 37.5000 4 no
GO:0001817 regulation of cytokine production 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0007010 cytoskeleton organization 37.5000 5 no
GO:0008104 protein localization 37.5000 4 no
GO:0009057 macromolecule catabolic process 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0009968 negative regulation of signal transduction 37.5000 5 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0010648 negative regulation of cell communication 37.5000 5 no
GO:0015031 protein transport 37.5000 4 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0023057 negative regulation of signaling 37.5000 4 no
GO:0030163 protein catabolic process 37.5000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042327 positive regulation of phosphorylation 37.5000 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 37.5000 7 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0042981 regulation of apoptotic process 37.5000 6 no
GO:0043067 regulation of programmed cell death 37.5000 5 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0006470 protein dephosphorylation 25.0000 5 yes
GO:0007088 regulation of mitotic nuclear division 25.0000 6 yes
GO:0007346 regulation of mitotic cell cycle 25.0000 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 25.0000 6 yes
GO:0009111 vitamin catabolic process 25.0000 4 yes
GO:0010638 positive regulation of organelle organization 25.0000 6 yes
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0014074 response to purine-containing compound 25.0000 5 yes
GO:0016311 dephosphorylation 25.0000 5 yes
GO:0030832 regulation of actin filament length 25.0000 5 yes
GO:0030834 regulation of actin filament depolymerization 25.0000 7 yes
GO:0030836 positive regulation of actin filament depolymerization 25.0000 7 yes
GO:0031247 actin rod assembly 25.0000 6 yes
GO:0032361 pyridoxal phosphate catabolic process 25.0000 5 yes
GO:0032535 regulation of cellular component size 25.0000 4 yes
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 yes
GO:0032970 regulation of actin filament-based process 25.0000 4 yes
GO:0033198 response to ATP 25.0000 4 yes
GO:0042365 water-soluble vitamin catabolic process 25.0000 5 yes
GO:0042820 vitamin B6 catabolic process 25.0000 6 yes
GO:0043243 positive regulation of protein-containing complex disassembly 25.0000 6 yes
GO:0043244 regulation of protein-containing complex disassembly 25.0000 5 yes
GO:0046185 aldehyde catabolic process 25.0000 4 yes
GO:0046683 response to organophosphorus 25.0000 4 yes
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 yes
GO:0051783 regulation of nuclear division 25.0000 6 yes
GO:0071318 cellular response to ATP 25.0000 5 yes
GO:0071407 cellular response to organic cyclic compound 25.0000 5 yes
GO:0072526 pyridine-containing compound catabolic process 25.0000 5 yes
GO:0110053 regulation of actin filament organization 25.0000 6 yes
GO:1901616 organic hydroxy compound catabolic process 25.0000 4 yes
GO:1901879 regulation of protein depolymerization 25.0000 6 yes
GO:1901881 positive regulation of protein depolymerization 25.0000 7 yes
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 yes
GO:0001818 negative regulation of cytokine production 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006508 proteolysis 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010498 proteasomal protein catabolic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0016567 protein ubiquitination 25.0000 7 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0031396 regulation of protein ubiquitination 25.0000 8 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0032446 protein modification by small protein conjugation 25.0000 6 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0043433 negative regulation of DNA-binding transcription factor activity 25.0000 4 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0044265 cellular macromolecule catabolic process 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0070647 protein modification by small protein conjugation or removal 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006259 DNA metabolic process 25.0000 4 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031334 positive regulation of protein-containing complex assembly 25.0000 6 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0034605 cellular response to heat 25.0000 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0071826 ribonucleoprotein complex subunit organization 25.0000 5 no
GO:0071897 DNA biosynthetic process 25.0000 5 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0050807 regulation of synapse organization 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLPP_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRLD1_HUMAN [view interactions] High throughput no yes
ZDH16_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
MED23_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
STK11_HUMAN [view interactions] High throughput no yes
PRAF1_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BACH1_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
NDUF5_HUMAN [view interactions] High throughput no yes
TPOR_HUMAN [view interactions] High throughput no no
RDH12_HUMAN [view interactions] High throughput no no
MFTC_HUMAN [view interactions] High throughput no yes
PAFA_HUMAN [view interactions] High throughput no no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
NFYA_HUMAN [view interactions] High throughput no yes
AOXA_HUMAN [view interactions] Computational no no
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
PNPO_HUMAN [view interactions] Computational no yes
PHOP2_HUMAN [view interactions] Computational no no
PDXK_HUMAN [view entry] [view interactions] Computational yes yes