Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLPP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5-phosphate (PNP) and pyridoxamine 5-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed, PubMed). Also functions as a protein serine phosphatase that specifically dephosphorylates Ser-3 in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLPP_HUMAN
GO:0043169 cation binding 62.5000 4 yes
GO:0046872 metal ion binding 62.5000 5 yes
GO:0042803 protein homodimerization activity 37.5000 4 yes
GO:0001664 G protein-coupled receptor binding 37.5000 4 no
GO:0002020 protease binding 37.5000 4 no
GO:0015631 tubulin binding 37.5000 4 no
GO:0031625 ubiquitin protein ligase binding 37.5000 5 no
GO:0044389 ubiquitin-like protein ligase binding 37.5000 4 no
GO:0000287 magnesium ion binding 25.0000 6 yes
GO:0004722 protein serine/threonine phosphatase activity 25.0000 4 yes
GO:0016791 phosphatase activity 25.0000 5 yes
GO:0017018 myosin phosphatase activity 25.0000 5 yes
GO:0033883 pyridoxal phosphatase activity 25.0000 6 yes
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 yes
GO:0017124 SH3 domain binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0046914 transition metal ion binding 25.0000 6 no
GO:1990381 ubiquitin-specific protease binding 25.0000 5 no
GO:0008017 microtubule binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PLPP_HUMAN
GO:0051128 regulation of cellular component organization 100.0000 4 yes
GO:0022607 cellular component assembly 87.5000 4 yes
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0036211 protein modification process 75.0000 4 yes
GO:0043412 macromolecule modification 75.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 75.0000 4 yes
GO:0010243 response to organonitrogen compound 62.5000 4 yes
GO:0051130 positive regulation of cellular component organization 62.5000 5 yes
GO:0097435 supramolecular fiber organization 62.5000 4 yes
GO:1901701 cellular response to oxygen-containing compound 62.5000 4 yes
GO:0009889 regulation of biosynthetic process 62.5000 4 no
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0051493 regulation of cytoskeleton organization 50.0000 6 yes
GO:0051726 regulation of cell cycle 50.0000 4 yes
GO:0071310 cellular response to organic substance 50.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 50.0000 4 yes
GO:1901699 cellular response to nitrogen compound 50.0000 4 yes
GO:0006508 proteolysis 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0009057 macromolecule catabolic process 50.0000 4 no
GO:0009890 negative regulation of biosynthetic process 50.0000 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010629 negative regulation of gene expression 50.0000 7 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0030163 protein catabolic process 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 50.0000 6 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0032880 regulation of protein localization 50.0000 5 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0007015 actin filament organization 37.5000 5 yes
GO:0010564 regulation of cell cycle process 37.5000 5 yes
GO:0010638 positive regulation of organelle organization 37.5000 6 yes
GO:0014070 response to organic cyclic compound 37.5000 4 yes
GO:0032465 regulation of cytokinesis 37.5000 5 yes
GO:0032956 regulation of actin cytoskeleton organization 37.5000 5 yes
GO:0032970 regulation of actin filament-based process 37.5000 4 yes
GO:0046434 organophosphate catabolic process 37.5000 4 yes
GO:0051017 actin filament bundle assembly 37.5000 5 yes
GO:0051302 regulation of cell division 37.5000 4 yes
GO:0061572 actin filament bundle organization 37.5000 6 yes
GO:0071407 cellular response to organic cyclic compound 37.5000 5 yes
GO:0072524 pyridine-containing compound metabolic process 37.5000 4 yes
GO:0110053 regulation of actin filament organization 37.5000 6 yes
GO:1901361 organic cyclic compound catabolic process 37.5000 4 yes
GO:1902903 regulation of supramolecular fiber organization 37.5000 5 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0006355 regulation of DNA-templated transcription 37.5000 7 no
GO:0006511 ubiquitin-dependent protein catabolic process 37.5000 7 no
GO:0008104 protein localization 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010498 proteasomal protein catabolic process 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0016567 protein ubiquitination 37.5000 8 no
GO:0019941 modification-dependent protein catabolic process 37.5000 6 no
GO:0022411 cellular component disassembly 37.5000 4 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0030162 regulation of proteolysis 37.5000 6 no
GO:0031400 negative regulation of protein modification process 37.5000 7 no
GO:0032446 protein modification by small protein conjugation 37.5000 7 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 37.5000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 37.5000 5 no
GO:0043687 post-translational protein modification 37.5000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0051603 proteolysis involved in protein catabolic process 37.5000 5 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0070647 protein modification by small protein conjugation or removal 37.5000 6 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:1901873 regulation of post-translational protein modification 37.5000 7 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 37.5000 8 no
GO:1905475 regulation of protein localization to membrane 37.5000 6 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 no
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0007010 cytoskeleton organization 37.5000 5 no
GO:0006470 protein dephosphorylation 25.0000 5 yes
GO:0006767 water-soluble vitamin metabolic process 25.0000 4 yes
GO:0007088 regulation of mitotic nuclear division 25.0000 6 yes
GO:0007346 regulation of mitotic cell cycle 25.0000 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 25.0000 6 yes
GO:0009111 vitamin catabolic process 25.0000 4 yes
GO:0014074 response to purine-containing compound 25.0000 5 yes
GO:0016311 dephosphorylation 25.0000 5 yes
GO:0030832 regulation of actin filament length 25.0000 5 yes
GO:0030834 regulation of actin filament depolymerization 25.0000 7 yes
GO:0030836 positive regulation of actin filament depolymerization 25.0000 7 yes
GO:0031247 actin rod assembly 25.0000 6 yes
GO:0032361 pyridoxal phosphate catabolic process 25.0000 5 yes
GO:0032535 regulation of cellular component size 25.0000 4 yes
GO:0033198 response to ATP 25.0000 4 yes
GO:0042365 water-soluble vitamin catabolic process 25.0000 5 yes
GO:0042816 vitamin B6 metabolic process 25.0000 5 yes
GO:0042820 vitamin B6 catabolic process 25.0000 6 yes
GO:0042822 pyridoxal phosphate metabolic process 25.0000 4 yes
GO:0043243 positive regulation of protein-containing complex disassembly 25.0000 6 yes
GO:0043244 regulation of protein-containing complex disassembly 25.0000 5 yes
GO:0046185 aldehyde catabolic process 25.0000 4 yes
GO:0046683 response to organophosphorus 25.0000 4 yes
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 yes
GO:0051783 regulation of nuclear division 25.0000 6 yes
GO:0071318 cellular response to ATP 25.0000 5 yes
GO:0072526 pyridine-containing compound catabolic process 25.0000 5 yes
GO:1901616 organic hydroxy compound catabolic process 25.0000 4 yes
GO:1901879 regulation of protein depolymerization 25.0000 6 yes
GO:1901881 positive regulation of protein depolymerization 25.0000 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 yes
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0007034 vacuolar transport 25.0000 4 no
GO:0007041 lysosomal transport 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0016236 macroautophagy 25.0000 4 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0030307 positive regulation of cell growth 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031648 protein destabilization 25.0000 4 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0034976 response to endoplasmic reticulum stress 25.0000 4 no
GO:0036503 ERAD pathway 25.0000 5 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043523 regulation of neuron apoptotic process 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045927 positive regulation of growth 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051881 regulation of mitochondrial membrane potential 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0060828 regulation of canonical Wnt signaling pathway 25.0000 6 no
GO:0061136 regulation of proteasomal protein catabolic process 25.0000 6 no
GO:0062012 regulation of small molecule metabolic process 25.0000 4 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0070841 inclusion body assembly 25.0000 5 no
GO:0070842 aggresome assembly 25.0000 6 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0098657 import into cell 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:1901800 positive regulation of proteasomal protein catabolic process 25.0000 7 no
GO:1901875 positive regulation of post-translational protein modification 25.0000 8 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:1903008 organelle disassembly 25.0000 5 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 25.0000 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 25.0000 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:1903533 regulation of protein targeting 25.0000 7 no
GO:1903828 negative regulation of protein localization 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 25.0000 5 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0001818 negative regulation of cytokine production 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0007162 negative regulation of cell adhesion 25.0000 5 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043433 negative regulation of DNA-binding transcription factor activity 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0099173 postsynapse organization 25.0000 4 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:1904375 regulation of protein localization to cell periphery 25.0000 6 no
GO:0008593 regulation of Notch signaling pathway 25.0000 5 no
GO:0015031 protein transport 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLPP_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
STK11_HUMAN [view interactions] High throughput no yes
PRAF1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BACH1_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
NDUF5_HUMAN [view interactions] High throughput no yes
TPOR_HUMAN [view interactions] High throughput no no
RDH12_HUMAN [view interactions] High throughput no no
S2532_HUMAN [view interactions] High throughput no yes
PAFA_HUMAN [view interactions] High throughput no no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
NFYA_HUMAN [view interactions] High throughput no yes
PRLD1_HUMAN [view interactions] High throughput no yes
ZDH16_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
MED23_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes