Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AIFM3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AIFM3_HUMAN
GO:0046872 metal ion binding 100.0000 4 yes
GO:0001664 G protein-coupled receptor binding 50.0000 4 no
GO:0004866 endopeptidase inhibitor activity 50.0000 5 no
GO:0030414 peptidase inhibitor activity 50.0000 4 no
GO:0046914 transition metal ion binding 50.0000 5 no
GO:0061135 endopeptidase regulator activity 50.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AIFM3_HUMAN
GO:0042327 positive regulation of phosphorylation 50.0000 8 no
GO:0042981 regulation of apoptotic process 50.0000 6 no
GO:0043065 positive regulation of apoptotic process 50.0000 7 no
GO:0043067 regulation of programmed cell death 50.0000 5 no
GO:0043068 positive regulation of programmed cell death 50.0000 6 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0043269 regulation of ion transport 50.0000 5 no
GO:0043523 regulation of neuron apoptotic process 50.0000 6 no
GO:0043525 positive regulation of neuron apoptotic process 50.0000 7 no
GO:0043549 regulation of kinase activity 50.0000 5 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0045859 regulation of protein kinase activity 50.0000 6 no
GO:0045860 positive regulation of protein kinase activity 50.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0046688 response to copper ion 50.0000 5 no
GO:0046916 cellular transition metal ion homeostasis 50.0000 7 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0048878 chemical homeostasis 50.0000 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 50.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 50.0000 9 no
GO:0050776 regulation of immune response 50.0000 4 no
GO:0050801 ion homeostasis 50.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0050807 regulation of synapse organization 50.0000 5 no
GO:0050865 regulation of cell activation 50.0000 4 no
GO:0050890 cognition 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051050 positive regulation of transport 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051129 negative regulation of cellular component organization 50.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051222 positive regulation of protein transport 50.0000 5 no
GO:0051223 regulation of protein transport 50.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0051259 protein complex oligomerization 50.0000 6 no
GO:0051260 protein homooligomerization 50.0000 7 no
GO:0051338 regulation of transferase activity 50.0000 4 no
GO:0051347 positive regulation of transferase activity 50.0000 5 no
GO:0055065 metal ion homeostasis 50.0000 7 no
GO:0055070 copper ion homeostasis 50.0000 9 no
GO:0055076 transition metal ion homeostasis 50.0000 8 no
GO:0055080 cation homeostasis 50.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0060548 negative regulation of cell death 50.0000 5 no
GO:0061097 regulation of protein tyrosine kinase activity 50.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 50.0000 8 no
GO:0065003 protein-containing complex assembly 50.0000 5 no
GO:0070201 regulation of establishment of protein localization 50.0000 6 no
GO:0071241 cellular response to inorganic substance 50.0000 4 no
GO:0071248 cellular response to metal ion 50.0000 5 no
GO:0071280 cellular response to copper ion 50.0000 6 no
GO:0071310 cellular response to organic substance 50.0000 4 no
GO:0071417 cellular response to organonitrogen compound 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0098771 inorganic ion homeostasis 50.0000 6 no
GO:0099175 regulation of postsynapse organization 50.0000 6 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0106027 neuron projection organization 50.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 no
GO:1900271 regulation of long-term synaptic potentiation 50.0000 4 no
GO:1900272 negative regulation of long-term synaptic potentiation 50.0000 4 no
GO:1901214 regulation of neuron death 50.0000 5 no
GO:1901216 positive regulation of neuron death 50.0000 6 no
GO:1901652 response to peptide 50.0000 4 no
GO:1901653 cellular response to peptide 50.0000 5 no
GO:1901699 cellular response to nitrogen compound 50.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:1902950 regulation of dendritic spine maintenance 50.0000 7 no
GO:1902951 negative regulation of dendritic spine maintenance 50.0000 7 no
GO:1902991 regulation of amyloid precursor protein catabolic process 50.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 50.0000 7 no
GO:1903829 positive regulation of protein localization 50.0000 5 no
GO:1904062 regulation of cation transmembrane transport 50.0000 6 no
GO:1904645 response to amyloid-beta 50.0000 5 no
GO:1904646 cellular response to amyloid-beta 50.0000 6 no
GO:1904951 positive regulation of establishment of protein localization 50.0000 6 no
GO:1990535 neuron projection maintenance 50.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0001817 regulation of cytokine production 50.0000 4 no
GO:0001932 regulation of protein phosphorylation 50.0000 7 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 no
GO:0006355 regulation of DNA-templated transcription 50.0000 6 no
GO:0006873 cellular ion homeostasis 50.0000 4 no
GO:0006875 cellular metal ion homeostasis 50.0000 6 no
GO:0006878 cellular copper ion homeostasis 50.0000 8 no
GO:0007613 memory 50.0000 4 no
GO:0008285 negative regulation of cell population proliferation 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0008202 steroid metabolic process 50.0000 4 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0008203 cholesterol metabolic process 50.0000 5 no
GO:0010038 response to metal ion 50.0000 4 no
GO:0010243 response to organonitrogen compound 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010629 negative regulation of gene expression 50.0000 6 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:1902652 secondary alcohol metabolic process 50.0000 4 no
GO:0010941 regulation of cell death 50.0000 4 no
GO:0010942 positive regulation of cell death 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0019722 calcium-mediated signaling 50.0000 5 no
GO:0019932 second-messenger-mediated signaling 50.0000 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 50.0000 4 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0030003 cellular cation homeostasis 50.0000 5 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0030162 regulation of proteolysis 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0031345 negative regulation of cell projection organization 50.0000 6 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0016125 sterol metabolic process 50.0000 4 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0032412 regulation of ion transmembrane transporter activity 50.0000 5 no
GO:0032649 regulation of interferon-gamma production 50.0000 5 no
GO:0032880 regulation of protein localization 50.0000 5 no
GO:0033674 positive regulation of kinase activity 50.0000 6 no
GO:0034248 regulation of cellular amide metabolic process 50.0000 5 no
GO:0034762 regulation of transmembrane transport 50.0000 4 no
GO:0034765 regulation of ion transmembrane transport 50.0000 5 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0042325 regulation of phosphorylation 50.0000 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMT1_HUMAN [view interactions] Low throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PPARG_HUMAN [view interactions] High throughput no yes
NMT2_HUMAN [view interactions] High throughput no yes
PGK2_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
GRK6_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
PPIF_HUMAN [view interactions] High throughput no no
ACOX3_HUMAN [view interactions] Computational no yes
ACD10_HUMAN [view interactions] Computational no no