Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE1A_HUMAN
GO:0046872 metal ion binding 72.7273 4 yes
GO:0005509 calcium ion binding 36.3636 5 no
GO:0019900 kinase binding 36.3636 4 no
GO:0019901 protein kinase binding 36.3636 5 no
GO:0017076 purine nucleotide binding 36.3636 4 no
GO:0032555 purine ribonucleotide binding 36.3636 4 no
GO:0008179 adenylate cyclase binding 27.2727 4 no
GO:0010856 adenylate cyclase activator activity 27.2727 4 no
GO:0019209 kinase activator activity 27.2727 4 no
GO:0019211 phosphatase activator activity 27.2727 4 no
GO:0019887 protein kinase regulator activity 27.2727 4 no
GO:0019888 protein phosphatase regulator activity 27.2727 4 no
GO:0030295 protein kinase activator activity 27.2727 5 no
GO:0031432 titin binding 27.2727 4 no
GO:0031997 N-terminal myristoylation domain binding 27.2727 4 no
GO:0043539 protein serine/threonine kinase activator activity 27.2727 6 no
GO:0072542 protein phosphatase activator activity 27.2727 5 no
GO:0097718 disordered domain specific binding 27.2727 4 no
GO:0019001 guanyl nucleotide binding 27.2727 5 no
GO:0032561 guanyl ribonucleotide binding 27.2727 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0004112 cyclic-nucleotide phosphodiesterase activity 18.1818 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 18.1818 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 18.1818 8 yes
GO:0008081 phosphoric diester hydrolase activity 18.1818 5 yes
GO:0042578 phosphoric ester hydrolase activity 18.1818 4 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 18.1818 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDE1A_HUMAN
GO:0010646 regulation of cell communication 72.7273 4 no
GO:0009966 regulation of signal transduction 63.6364 4 no
GO:1902531 regulation of intracellular signal transduction 63.6364 5 no
GO:0031323 regulation of cellular metabolic process 54.5455 4 no
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0051171 regulation of nitrogen compound metabolic process 54.5455 4 no
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 no
GO:0080090 regulation of primary metabolic process 54.5455 4 no
GO:0019722 calcium-mediated signaling 45.4545 5 no
GO:0019932 second-messenger-mediated signaling 45.4545 4 no
GO:0001932 regulation of protein phosphorylation 45.4545 7 no
GO:0001934 positive regulation of protein phosphorylation 45.4545 8 no
GO:0006796 phosphate-containing compound metabolic process 45.4545 4 no
GO:0009892 negative regulation of metabolic process 45.4545 4 no
GO:0009893 positive regulation of metabolic process 45.4545 4 no
GO:0010038 response to metal ion 45.4545 4 no
GO:0010562 positive regulation of phosphorus metabolic process 45.4545 6 no
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 no
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 no
GO:0019220 regulation of phosphate metabolic process 45.4545 6 no
GO:0031324 negative regulation of cellular metabolic process 45.4545 5 no
GO:0031325 positive regulation of cellular metabolic process 45.4545 5 no
GO:0031399 regulation of protein modification process 45.4545 6 no
GO:0031401 positive regulation of protein modification process 45.4545 7 no
GO:0033674 positive regulation of kinase activity 45.4545 6 no
GO:0042325 regulation of phosphorylation 45.4545 7 no
GO:0042327 positive regulation of phosphorylation 45.4545 8 no
GO:0043085 positive regulation of catalytic activity 45.4545 4 no
GO:0043549 regulation of kinase activity 45.4545 5 no
GO:0045859 regulation of protein kinase activity 45.4545 6 no
GO:0045860 positive regulation of protein kinase activity 45.4545 7 no
GO:0045937 positive regulation of phosphate metabolic process 45.4545 7 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0051050 positive regulation of transport 45.4545 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 45.4545 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.4545 5 no
GO:0051174 regulation of phosphorus metabolic process 45.4545 5 no
GO:0051246 regulation of protein metabolic process 45.4545 5 no
GO:0051247 positive regulation of protein metabolic process 45.4545 6 no
GO:0051338 regulation of transferase activity 45.4545 4 no
GO:0051347 positive regulation of transferase activity 45.4545 5 no
GO:0010564 regulation of cell cycle process 36.3636 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 36.3636 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 36.3636 9 no
GO:0022898 regulation of transmembrane transporter activity 36.3636 4 no
GO:0032412 regulation of ion transmembrane transporter activity 36.3636 5 no
GO:0034762 regulation of transmembrane transport 36.3636 4 no
GO:0034765 regulation of ion transmembrane transport 36.3636 5 no
GO:0043269 regulation of ion transport 36.3636 5 no
GO:0044057 regulation of system process 36.3636 4 no
GO:0051099 positive regulation of binding 36.3636 4 no
GO:0051336 regulation of hydrolase activity 36.3636 4 no
GO:0051345 positive regulation of hydrolase activity 36.3636 5 no
GO:0051592 response to calcium ion 36.3636 5 no
GO:0051726 regulation of cell cycle 36.3636 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 36.3636 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 36.3636 8 no
GO:1903522 regulation of blood circulation 36.3636 5 no
GO:1904062 regulation of cation transmembrane transport 36.3636 6 no
GO:2001257 regulation of cation channel activity 36.3636 6 no
GO:0000086 G2/M transition of mitotic cell cycle 27.2727 5 no
GO:0001933 negative regulation of protein phosphorylation 27.2727 8 no
GO:0005513 detection of calcium ion 27.2727 4 no
GO:0006468 protein phosphorylation 27.2727 5 no
GO:0006937 regulation of muscle contraction 27.2727 6 no
GO:0006942 regulation of striated muscle contraction 27.2727 7 no
GO:0008016 regulation of heart contraction 27.2727 6 no
GO:0010243 response to organonitrogen compound 27.2727 4 no
GO:0010563 negative regulation of phosphorus metabolic process 27.2727 6 no
GO:0010649 regulation of cell communication by electrical coupling 27.2727 5 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 27.2727 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 27.2727 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 27.2727 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 27.2727 6 no
GO:0010921 regulation of phosphatase activity 27.2727 5 no
GO:0010922 positive regulation of phosphatase activity 27.2727 6 no
GO:0010941 regulation of cell death 27.2727 4 no
GO:0010959 regulation of metal ion transport 27.2727 6 no
GO:0014070 response to organic cyclic compound 27.2727 4 no
GO:0016310 phosphorylation 27.2727 5 no
GO:0021762 substantia nigra development 27.2727 4 no
GO:0031400 negative regulation of protein modification process 27.2727 7 no
GO:0031952 regulation of protein autophosphorylation 27.2727 8 no
GO:0031954 positive regulation of protein autophosphorylation 27.2727 9 no
GO:0032410 negative regulation of transporter activity 27.2727 4 no
GO:0032411 positive regulation of transporter activity 27.2727 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 27.2727 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 27.2727 5 no
GO:0032465 regulation of cytokinesis 27.2727 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 27.2727 7 no
GO:0034763 negative regulation of transmembrane transport 27.2727 5 no
GO:0034764 positive regulation of transmembrane transport 27.2727 5 no
GO:0034766 negative regulation of ion transmembrane transport 27.2727 6 no
GO:0034767 positive regulation of ion transmembrane transport 27.2727 6 no
GO:0035303 regulation of dephosphorylation 27.2727 7 no
GO:0035304 regulation of protein dephosphorylation 27.2727 7 no
GO:0035306 positive regulation of dephosphorylation 27.2727 8 no
GO:0035307 positive regulation of protein dephosphorylation 27.2727 8 no
GO:0036211 protein modification process 27.2727 4 no
GO:0042326 negative regulation of phosphorylation 27.2727 8 no
GO:0042981 regulation of apoptotic process 27.2727 6 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0043270 positive regulation of ion transport 27.2727 5 no
GO:0043271 negative regulation of ion transport 27.2727 5 no
GO:0043388 positive regulation of DNA binding 27.2727 5 no
GO:0043412 macromolecule modification 27.2727 4 no
GO:0043666 regulation of phosphoprotein phosphatase activity 27.2727 6 no
GO:0044772 mitotic cell cycle phase transition 27.2727 4 no
GO:0044839 cell cycle G2/M phase transition 27.2727 4 no
GO:0045936 negative regulation of phosphate metabolic process 27.2727 7 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 no
GO:0050848 regulation of calcium-mediated signaling 27.2727 6 no
GO:0051051 negative regulation of transport 27.2727 4 no
GO:0051101 regulation of DNA binding 27.2727 4 no
GO:0051128 regulation of cellular component organization 27.2727 4 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 27.2727 5 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 27.2727 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 27.2727 6 no
GO:0051282 regulation of sequestering of calcium ion 27.2727 4 no
GO:0051284 positive regulation of sequestering of calcium ion 27.2727 5 no
GO:0051302 regulation of cell division 27.2727 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 27.2727 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 27.2727 6 no
GO:0051924 regulation of calcium ion transport 27.2727 7 no
GO:0051926 negative regulation of calcium ion transport 27.2727 6 no
GO:0051928 positive regulation of calcium ion transport 27.2727 6 no
GO:0055117 regulation of cardiac muscle contraction 27.2727 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 27.2727 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 27.2727 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 27.2727 7 no
GO:0090257 regulation of muscle system process 27.2727 5 no
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 27.2727 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 27.2727 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 27.2727 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 27.2727 6 no
GO:1903169 regulation of calcium ion transmembrane transport 27.2727 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 27.2727 7 no
GO:1904063 negative regulation of cation transmembrane transport 27.2727 7 no
GO:1904064 positive regulation of cation transmembrane transport 27.2727 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 27.2727 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 27.2727 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 27.2727 8 no
GO:2001258 negative regulation of cation channel activity 27.2727 6 no
GO:2001259 positive regulation of cation channel activity 27.2727 6 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0006355 regulation of DNA-templated transcription 27.2727 6 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 5 no
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:1903506 regulation of nucleic acid-templated transcription 27.2727 7 no
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 no

Disease

Term Name % Distance from top the of the tree Annotated in PDE1A_HUMAN
DOID:0050700 cardiomyopathy 18.1818 4 no
DOID:0060036 intrinsic cardiomyopathy 18.1818 5 no
DOID:114 heart disease 18.1818 3 no
DOID:2843 long QT syndrome 18.1818 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
APOA1_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PDE1C_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PDE11_HUMAN [view entry] [view interactions] High throughput yes yes
PDE4A_HUMAN [view interactions] High throughput no no
LAT1_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
APT_HUMAN [view interactions] Computational no yes
GNAT3_HUMAN [view interactions] Computational no no
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
PUR8_HUMAN [view interactions] Computational no yes
ADCY5_HUMAN [view interactions] Computational no no
GBG13_HUMAN [view interactions] Computational no no
DCK_HUMAN [view interactions] Computational no no
ADCY6_HUMAN [view interactions] Computational no yes
PDE1B_HUMAN [view interactions] Computational no yes
GBB3_HUMAN [view interactions] Computational no yes
NCALD_HUMAN [view entry] [view interactions] Computational yes yes
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
GCYA2_HUMAN [view entry] [view interactions] Computational yes yes