PDE1A_HUMAN
Evidence for PS localization
Functions
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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PDE1A_HUMAN has binary interactions with 7 proteins
Isoforms
Interacting regions
Canonical [PDE1A_HUMAN]
Isoform [P54750-2] alignment
Isoform [P54750-3] alignment
Isoform [P54750-4] alignment
Isoform [P54750-5] alignment
Isoform [P54750-6] alignment
Isoform [P54750-7] alignment
Isoform [P54750-8] alignment
Isoform [P54750-9] alignment
Isoform [A0A8Q3WKY5] alignment
LOADING 86%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PDE1A_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 75.0000 | 4 | yes |
GO:0046872 | metal ion binding | 75.0000 | 5 | yes |
GO:0019900 | kinase binding | 50.0000 | 4 | no |
GO:0019901 | protein kinase binding | 50.0000 | 5 | no |
GO:0005509 | calcium ion binding | 37.5000 | 6 | no |
GO:0010853 | cyclase activator activity | 37.5000 | 4 | no |
GO:0010854 | adenylate cyclase regulator activity | 37.5000 | 4 | no |
GO:0010856 | adenylate cyclase activator activity | 37.5000 | 5 | no |
GO:0019209 | kinase activator activity | 37.5000 | 4 | no |
GO:0019211 | phosphatase activator activity | 37.5000 | 4 | no |
GO:0019887 | protein kinase regulator activity | 37.5000 | 4 | no |
GO:0019888 | protein phosphatase regulator activity | 37.5000 | 4 | no |
GO:0030295 | protein kinase activator activity | 37.5000 | 5 | no |
GO:0031432 | titin binding | 37.5000 | 4 | no |
GO:0043539 | protein serine/threonine kinase activator activity | 37.5000 | 6 | no |
GO:0072542 | protein phosphatase activator activity | 37.5000 | 5 | no |
GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 25.0000 | 6 | yes |
GO:0004114 | 3,5-cyclic-nucleotide phosphodiesterase activity | 25.0000 | 7 | yes |
GO:0004115 | 3,5-cyclic-AMP phosphodiesterase activity | 25.0000 | 8 | yes |
GO:0008081 | phosphoric diester hydrolase activity | 25.0000 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 25.0000 | 4 | yes |
GO:0047555 | 3,5-cyclic-GMP phosphodiesterase activity | 25.0000 | 8 | yes |
GO:0005246 | calcium channel regulator activity | 25.0000 | 5 | no |
GO:0008200 | ion channel inhibitor activity | 25.0000 | 5 | no |
GO:0016248 | channel inhibitor activity | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PDE1A_HUMAN |
---|---|---|---|---|
GO:0009966 | regulation of signal transduction | 75.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 75.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 75.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 62.5000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 62.5000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 62.5000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 62.5000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 62.5000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 62.5000 | 4 | no |
GO:0000086 | G2/M transition of mitotic cell cycle | 50.0000 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 50.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 50.0000 | 8 | no |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 50.0000 | 6 | no |
GO:0010564 | regulation of cell cycle process | 50.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0010799 | regulation of peptidyl-threonine phosphorylation | 50.0000 | 8 | no |
GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 50.0000 | 9 | no |
GO:0019220 | regulation of phosphate metabolic process | 50.0000 | 6 | no |
GO:0022898 | regulation of transmembrane transporter activity | 50.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 50.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 50.0000 | 7 | no |
GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 50.0000 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOA1_HUMAN | [view interactions] | Low throughput | no | no |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
LAT1_HUMAN | [view interactions] | High throughput | no | yes |
PDE11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDE1C_HUMAN | [view interactions] | High throughput | no | no |
PDE4A_HUMAN | [view interactions] | High throughput | no | no |
RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |