Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE11_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE11_HUMAN
GO:0017076 purine nucleotide binding 85.7143 4 yes
GO:0032555 purine ribonucleotide binding 85.7143 4 yes
GO:0046872 metal ion binding 57.1429 4 yes
GO:0030554 adenyl nucleotide binding 57.1429 5 no
GO:0032559 adenyl ribonucleotide binding 57.1429 5 no
GO:0035639 purine ribonucleoside triphosphate binding 57.1429 4 no
GO:0019001 guanyl nucleotide binding 42.8571 5 yes
GO:0032561 guanyl ribonucleotide binding 42.8571 5 yes
GO:0031625 ubiquitin protein ligase binding 42.8571 5 no
GO:0044389 ubiquitin-like protein ligase binding 42.8571 4 no
GO:0005524 ATP binding 42.8571 5 no
GO:0016301 kinase activity 42.8571 4 no
GO:0004112 cyclic-nucleotide phosphodiesterase activity 28.5714 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 28.5714 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 28.5714 8 yes
GO:0008081 phosphoric diester hydrolase activity 28.5714 5 yes
GO:0030551 cyclic nucleotide binding 28.5714 4 yes
GO:0042578 phosphoric ester hydrolase activity 28.5714 4 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 28.5714 8 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0000287 magnesium ion binding 28.5714 5 no
GO:0004674 protein serine/threonine kinase activity 28.5714 4 no
GO:0004679 AMP-activated protein kinase activity 28.5714 5 no
GO:0004690 cyclic nucleotide-dependent protein kinase activity 28.5714 5 no
GO:0004691 cAMP-dependent protein kinase activity 28.5714 6 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 28.5714 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0106310 protein serine kinase activity 28.5714 4 no
GO:0005525 GTP binding 28.5714 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PDE11_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0009966 regulation of signal transduction 57.1429 4 yes
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0010468 regulation of gene expression 57.1429 5 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0051246 regulation of protein metabolic process 57.1429 5 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0009968 negative regulation of signal transduction 42.8571 5 yes
GO:0010648 negative regulation of cell communication 42.8571 5 yes
GO:0023057 negative regulation of signaling 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0006796 phosphate-containing compound metabolic process 42.8571 4 no
GO:0010737 protein kinase A signaling 28.5714 4 no
GO:0016310 phosphorylation 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0030104 water homeostasis 28.5714 5 no
GO:0030162 regulation of proteolysis 28.5714 6 no
GO:0034380 high-density lipoprotein particle assembly 28.5714 4 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0045879 negative regulation of smoothened signaling pathway 28.5714 6 no
GO:0048878 chemical homeostasis 28.5714 4 no
GO:0060606 tube closure 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0065005 protein-lipid complex assembly 28.5714 6 no
GO:0070613 regulation of protein processing 28.5714 7 no
GO:0071825 protein-lipid complex subunit organization 28.5714 5 no
GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 28.5714 6 no
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 28.5714 7 no
GO:1903317 regulation of protein maturation 28.5714 6 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0048522 positive regulation of cellular process 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 yes
GO:0001707 mesoderm formation 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0001843 neural tube closure 28.5714 5 no
GO:0003091 renal water homeostasis 28.5714 4 no
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0008589 regulation of smoothened signaling pathway 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ODFP2_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
PDE1A_HUMAN [view entry] [view interactions] High throughput yes yes
DCK_HUMAN [view interactions] Computational no no
APT_HUMAN [view interactions] Computational no yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
TT30B_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
PUR8_HUMAN [view interactions] Computational no yes