PDE11_HUMAN
Evidence for PS localization
Functions
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PDE11_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 66.6667 | 4 | yes |
| GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 66.6667 | 6 | yes |
| GO:0004114 | 3,5-cyclic-nucleotide phosphodiesterase activity | 66.6667 | 7 | yes |
| GO:0004115 | 3,5-cyclic-AMP phosphodiesterase activity | 66.6667 | 8 | yes |
| GO:0008081 | phosphoric diester hydrolase activity | 66.6667 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 66.6667 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 66.6667 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 66.6667 | 4 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 66.6667 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 66.6667 | 4 | yes |
| GO:0043168 | anion binding | 66.6667 | 4 | yes |
| GO:0043169 | cation binding | 66.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 66.6667 | 5 | yes |
| GO:0047555 | 3,5-cyclic-GMP phosphodiesterase activity | 66.6667 | 8 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PDE11_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 66.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 66.6667 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 66.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 66.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 66.6667 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |