Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA2_HUMAN
GO:0005216 ion channel activity 100.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 100.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 100.0000 7 yes
GO:0005261 cation channel activity 100.0000 5 yes
GO:0008324 cation transmembrane transporter activity 100.0000 4 yes
GO:0015267 channel activity 100.0000 4 yes
GO:0015276 ligand-gated ion channel activity 100.0000 5 yes
GO:0022824 transmitter-gated ion channel activity 100.0000 5 yes
GO:0022834 ligand-gated channel activity 100.0000 6 yes
GO:0022835 transmitter-gated channel activity 100.0000 4 yes
GO:0022836 gated channel activity 100.0000 5 yes
GO:0022848 acetylcholine-gated cation-selective channel activity 100.0000 7 yes
GO:0022890 inorganic cation transmembrane transporter activity 100.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 100.0000 4 yes
GO:0099094 ligand-gated cation channel activity 100.0000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 100.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 100.0000 6 yes
GO:0015464 acetylcholine receptor activity 77.7778 4 yes
GO:0005262 calcium channel activity 22.2222 6 no
GO:0015085 calcium ion transmembrane transporter activity 22.2222 6 no
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA2_HUMAN
GO:0006811 ion transport 100.0000 4 yes
GO:0007268 chemical synaptic transmission 100.0000 6 yes
GO:0098916 anterograde trans-synaptic signaling 100.0000 5 yes
GO:0099537 trans-synaptic signaling 100.0000 4 yes
GO:0007271 synaptic transmission, cholinergic 88.8889 7 yes
GO:0051899 membrane depolarization 88.8889 4 yes
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 55.5556 5 no
GO:0051046 regulation of secretion 55.5556 5 no
GO:0051049 regulation of transport 55.5556 4 no
GO:0099177 regulation of trans-synaptic signaling 55.5556 4 no
GO:1903530 regulation of secretion by cell 55.5556 4 no
GO:0035095 behavioral response to nicotine 44.4444 4 no
GO:0048522 positive regulation of cellular process 44.4444 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.4444 4 no
GO:0007274 neuromuscular synaptic transmission 33.3333 7 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0046928 regulation of neurotransmitter secretion 33.3333 4 no
GO:0051588 regulation of neurotransmitter transport 33.3333 5 no
GO:0060084 synaptic transmission involved in micturition 33.3333 8 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051952 regulation of amine transport 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0095500 acetylcholine receptor signaling pathway 33.3333 4 no
GO:1905144 response to acetylcholine 33.3333 4 no
GO:0006812 cation transport 33.3333 5 no
GO:0006816 calcium ion transport 33.3333 7 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0036293 response to decreased oxygen levels 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0001508 action potential 22.2222 4 no
GO:0006936 muscle contraction 22.2222 4 no
GO:0006937 regulation of muscle contraction 22.2222 6 no
GO:0006939 smooth muscle contraction 22.2222 5 no
GO:0006940 regulation of smooth muscle contraction 22.2222 7 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031644 regulation of nervous system process 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0090257 regulation of muscle system process 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048814 regulation of dendrite morphogenesis 22.2222 5 no
GO:0050773 regulation of dendrite development 22.2222 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0060078 regulation of postsynaptic membrane potential 22.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0007613 memory 22.2222 4 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0009966 regulation of signal transduction 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0032990 cell part morphogenesis 22.2222 4 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0048523 negative regulation of cellular process 22.2222 4 no
GO:0048812 neuron projection morphogenesis 22.2222 7 no
GO:0048858 cell projection morphogenesis 22.2222 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 no
GO:0080164 regulation of nitric oxide metabolic process 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 6 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0007600 sensory perception 22.2222 4 no
GO:0014059 regulation of dopamine secretion 22.2222 6 no
GO:0019233 sensory perception of pain 22.2222 5 no
GO:0042113 B cell activation 22.2222 4 no
GO:0050433 regulation of catecholamine secretion 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA7_HUMAN [view entry] [view interactions] Computational yes yes
ACHA9_HUMAN [view entry] [view interactions] Computational yes no
ACHA3_HUMAN [view entry] [view interactions] Computational yes no
ACHA4_HUMAN [view entry] [view interactions] Computational yes no
ACHB4_HUMAN [view entry] [view interactions] Computational yes no
ACHB3_HUMAN [view entry] [view interactions] Computational yes no
ACHB2_HUMAN [view entry] [view interactions] Computational yes no