Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA2_HUMAN
GO:0005216 monoatomic ion channel activity 100.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 100.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 100.0000 7 yes
GO:0005261 monoatomic cation channel activity 100.0000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 100.0000 4 yes
GO:0015267 channel activity 100.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 100.0000 5 yes
GO:0015464 acetylcholine receptor activity 100.0000 4 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 100.0000 5 yes
GO:0022834 ligand-gated channel activity 100.0000 6 yes
GO:0022835 transmitter-gated channel activity 100.0000 4 yes
GO:0022836 gated channel activity 100.0000 5 yes
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 100.0000 7 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 100.0000 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 100.0000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 100.0000 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 100.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA2_HUMAN
GO:0006811 monoatomic ion transport 100.0000 4 yes
GO:0007268 chemical synaptic transmission 100.0000 7 yes
GO:0007271 synaptic transmission, cholinergic 100.0000 8 yes
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0031644 regulation of nervous system process 100.0000 5 yes
GO:0044057 regulation of system process 100.0000 4 yes
GO:0071316 cellular response to nicotine 100.0000 4 yes
GO:0098828 modulation of inhibitory postsynaptic potential 100.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 100.0000 6 yes
GO:0099536 synaptic signaling 100.0000 4 yes
GO:0099537 trans-synaptic signaling 100.0000 5 yes
GO:1905144 response to acetylcholine 100.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA2_HUMAN [view entry] [view interactions] Low throughput yes no