ACHB3_HUMAN
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACHB3_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 100.0000 | 4 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 100.0000 | 6 | yes |
GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 100.0000 | 7 | yes |
GO:0005261 | cation channel activity | 100.0000 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015267 | channel activity | 100.0000 | 4 | yes |
GO:0015276 | ligand-gated ion channel activity | 100.0000 | 5 | yes |
GO:0022824 | transmitter-gated ion channel activity | 100.0000 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
GO:0022835 | transmitter-gated channel activity | 100.0000 | 4 | yes |
GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
GO:0022848 | acetylcholine-gated cation-selective channel activity | 100.0000 | 7 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 100.0000 | 4 | yes |
GO:0099094 | ligand-gated cation channel activity | 100.0000 | 6 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 100.0000 | 5 | yes |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 100.0000 | 6 | yes |
GO:0015464 | acetylcholine receptor activity | 80.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACHB3_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 100.0000 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 100.0000 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 100.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 100.0000 | 4 | yes |
GO:0007271 | synaptic transmission, cholinergic | 80.0000 | 7 | yes |
GO:0051046 | regulation of secretion | 80.0000 | 5 | yes |
GO:0051049 | regulation of transport | 80.0000 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 80.0000 | 4 | yes |
GO:0051899 | membrane depolarization | 80.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 60.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 60.0000 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 60.0000 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 60.0000 | 4 | yes |
GO:0017157 | regulation of exocytosis | 40.0000 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 40.0000 | 4 | yes |
GO:1903305 | regulation of regulated secretory pathway | 40.0000 | 6 | yes |
GO:2000300 | regulation of synaptic vesicle exocytosis | 40.0000 | 5 | yes |
GO:0001508 | action potential | 40.0000 | 4 | no |
GO:0035095 | behavioral response to nicotine | 40.0000 | 4 | no |
GO:0014059 | regulation of dopamine secretion | 40.0000 | 6 | no |
GO:0043269 | regulation of ion transport | 40.0000 | 5 | no |
GO:0050433 | regulation of catecholamine secretion | 40.0000 | 5 | no |
GO:0051952 | regulation of amine transport | 40.0000 | 5 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
ROAA_HUMAN | [view interactions] | High throughput | no | yes |
ZG16B_HUMAN | [view interactions] | High throughput | no | no |
GAMT_HUMAN | [view interactions] | High throughput | no | no |
NPW_HUMAN | [view interactions] | High throughput | no | no |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
ACHA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHB4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |