CEL_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed, PubMed, PubMed, PubMed). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs . Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed, PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CEL_HUMAN |
|---|---|---|---|---|
| GO:0004771 | sterol esterase activity | 100.0000 | 5 | yes |
| GO:0004806 | triglyceride lipase activity | 100.0000 | 5 | yes |
| GO:0016298 | lipase activity | 100.0000 | 4 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 100.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CEL_HUMAN |
|---|---|---|---|---|
| GO:0016042 | lipid catabolic process | 100.0000 | 4 | yes |
| GO:0016125 | sterol metabolic process | 100.0000 | 4 | yes |
| GO:0036211 | protein modification process | 100.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 100.0000 | 4 | yes |
| GO:0044242 | cellular lipid catabolic process | 100.0000 | 4 | yes |
| GO:1902652 | secondary alcohol metabolic process | 100.0000 | 4 | yes |
| GO:0008202 | steroid metabolic process | 100.0000 | 4 | yes |
| GO:0008203 | cholesterol metabolic process | 100.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PMGE_HUMAN | [view interactions] | High throughput | no | no |
| ST2B1_HUMAN | [view interactions] | Computational | no | yes |
| CP11A_HUMAN | [view interactions] | Computational | no | no |
| LIPC_HUMAN | [view interactions] | Computational | no | no |
| CP46A_HUMAN | [view interactions] | Computational | no | no |
| PLPL3_HUMAN | [view interactions] | Computational | no | no |
| DHC24_HUMAN | [view interactions] | Computational | no | yes |
| CBPA1_HUMAN | [view interactions] | Computational | no | no |
| LIPE_HUMAN | [view interactions] | Computational | no | no |
| LIPG_HUMAN | [view interactions] | Computational | no | no |
| COL_HUMAN | [view interactions] | Computational | no | no |
| LICH_HUMAN | [view interactions] | Computational | no | yes |
| CTRB1_HUMAN | [view interactions] | Computational | no | no |
| CP27A_HUMAN | [view interactions] | Computational | no | yes |
| CP7A1_HUMAN | [view interactions] | Computational | no | no |
| PLPL2_HUMAN | [view interactions] | Computational | no | no |
| CEL3B_HUMAN | [view interactions] | Computational | no | no |
| CBPB1_HUMAN | [view interactions] | Computational | no | no |
| CTRL_HUMAN | [view interactions] | Computational | no | no |
| DHCR7_HUMAN | [view interactions] | Computational | no | yes |
| LIPS_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CH25H_HUMAN | [view interactions] | Computational | no | no |
| LIPR1_HUMAN | [view interactions] | Computational | no | no |
| LIPR3_HUMAN | [view interactions] | Computational | no | no |
| PKHA3_HUMAN | [view interactions] | Computational | no | yes |
| PKHA8_HUMAN | [view interactions] | Computational | no | no |
| LIPP_HUMAN | [view interactions] | Computational | no | no |