Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FAAH1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed, PubMed, PubMed). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed, PubMed). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FAAH1_HUMAN
GO:0016298 lipase activity 62.5000 4 yes
GO:0047372 acylglycerol lipase activity 62.5000 5 yes
GO:0052689 carboxylic ester hydrolase activity 62.5000 4 yes
GO:0046872 metal ion binding 50.0000 4 no
GO:0004040 amidase activity 25.0000 5 yes
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 25.0000 4 yes
GO:0017064 fatty acid amide hydrolase activity 25.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FAAH1_HUMAN
GO:0019369 arachidonic acid metabolic process 62.5000 4 yes
GO:0019752 carboxylic acid metabolic process 62.5000 5 yes
GO:0032787 monocarboxylic acid metabolic process 62.5000 6 yes
GO:0033559 unsaturated fatty acid metabolic process 62.5000 5 yes
GO:0043436 oxoacid metabolic process 62.5000 4 yes
GO:0044057 regulation of system process 62.5000 4 yes
GO:0046486 glycerolipid metabolic process 62.5000 4 yes
GO:0051240 positive regulation of multicellular organismal process 62.5000 4 yes
GO:0001676 long-chain fatty acid metabolic process 62.5000 5 yes
GO:0006631 fatty acid metabolic process 62.5000 4 yes
GO:0006690 icosanoid metabolic process 62.5000 6 yes
GO:0016042 lipid catabolic process 62.5000 4 yes
GO:0044242 cellular lipid catabolic process 50.0000 4 yes
GO:0046461 neutral lipid catabolic process 50.0000 5 yes
GO:0046464 acylglycerol catabolic process 50.0000 6 yes
GO:0046503 glycerolipid catabolic process 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006638 neutral lipid metabolic process 50.0000 4 yes
GO:0006639 acylglycerol metabolic process 50.0000 5 yes
GO:0046462 monoacylglycerol metabolic process 37.5000 6 yes
GO:0052651 monoacylglycerol catabolic process 37.5000 7 yes
GO:1903522 regulation of blood circulation 37.5000 5 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0019216 regulation of lipid metabolic process 37.5000 5 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0003018 vascular process in circulatory system 37.5000 4 yes
GO:0016054 organic acid catabolic process 25.0000 4 yes
GO:0019229 regulation of vasoconstriction 25.0000 6 yes
GO:0035150 regulation of tube size 25.0000 4 yes
GO:0035296 regulation of tube diameter 25.0000 5 yes
GO:0045907 positive regulation of vasoconstriction 25.0000 5 yes
GO:0046395 carboxylic acid catabolic process 25.0000 5 yes
GO:0072329 monocarboxylic acid catabolic process 25.0000 6 yes
GO:0097746 blood vessel diameter maintenance 25.0000 5 yes
GO:0006644 phospholipid metabolic process 25.0000 4 no
GO:0006650 glycerophospholipid metabolic process 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0008610 lipid biosynthetic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0015849 organic acid transport 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0046890 regulation of lipid biosynthetic process 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 25.0000 4 no
GO:0007405 neuroblast proliferation 25.0000 4 no
GO:0022008 neurogenesis 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0038171 cannabinoid signaling pathway 25.0000 4 no
GO:0042136 neurotransmitter biosynthetic process 25.0000 4 no
GO:0045834 positive regulation of lipid metabolic process 25.0000 5 no
GO:0050727 regulation of inflammatory response 25.0000 5 no
GO:0071926 endocannabinoid signaling pathway 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0098917 retrograde trans-synaptic signaling 25.0000 5 no
GO:0098920 retrograde trans-synaptic signaling by lipid 25.0000 6 no
GO:0098921 retrograde trans-synaptic signaling by endocannabinoid 25.0000 7 no
GO:0099537 trans-synaptic signaling 25.0000 4 no
GO:0099541 trans-synaptic signaling by lipid 25.0000 5 no
GO:0099542 trans-synaptic signaling by endocannabinoid 25.0000 6 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0009062 fatty acid catabolic process 25.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FAAH1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NEP_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
NT2NA_HUMAN [view interactions] High throughput no no
CXCR2_HUMAN [view interactions] High throughput no no
DCPS_HUMAN [view interactions] High throughput no yes
S39A4_HUMAN [view interactions] High throughput no no
CP19A_HUMAN [view interactions] High throughput no no
PIGH_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
ZDH12_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
FABP5_HUMAN [view entry] [view interactions] Computational yes no
TRPV1_HUMAN [view entry] [view interactions] Computational yes no
NAAA_HUMAN [view interactions] Computational no yes
GPR55_HUMAN [view interactions] Computational no no
DGLA_HUMAN [view entry] [view interactions] Computational yes yes
ABHD6_HUMAN [view entry] [view interactions] Computational yes yes
GATB_HUMAN [view interactions] Computational no yes
CNR2_HUMAN [view interactions] Computational no yes
ABD12_HUMAN [view interactions] Computational no no
DGLB_HUMAN [view entry] [view interactions] Computational yes no
CNR1_HUMAN [view interactions] Computational no yes
NAPEP_HUMAN [view interactions] Computational no yes