FAAH1_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed, PubMed, PubMed). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed, PubMed). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FAAH1_HUMAN |
|---|---|---|---|---|
| GO:0004040 | amidase activity | 66.6667 | 5 | yes |
| GO:0016298 | lipase activity | 66.6667 | 4 | yes |
| GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 66.6667 | 4 | yes |
| GO:0017064 | fatty acid amide hydrolase activity | 66.6667 | 5 | yes |
| GO:0047372 | acylglycerol lipase activity | 66.6667 | 5 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 66.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FAAH1_HUMAN |
|---|---|---|---|---|
| GO:0044057 | regulation of system process | 100.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 100.0000 | 4 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 66.6667 | 5 | yes |
| GO:0003018 | vascular process in circulatory system | 66.6667 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 66.6667 | 4 | yes |
| GO:0006638 | neutral lipid metabolic process | 66.6667 | 4 | yes |
| GO:0006639 | acylglycerol metabolic process | 66.6667 | 5 | yes |
| GO:0006690 | icosanoid metabolic process | 66.6667 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 66.6667 | 5 | yes |
| GO:0016042 | lipid catabolic process | 66.6667 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 66.6667 | 4 | yes |
| GO:0019229 | regulation of vasoconstriction | 66.6667 | 6 | yes |
| GO:0019369 | arachidonic acid metabolic process | 66.6667 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 66.6667 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 66.6667 | 6 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 66.6667 | 5 | yes |
| GO:0035150 | regulation of tube size | 66.6667 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 66.6667 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 66.6667 | 4 | yes |
| GO:0044242 | cellular lipid catabolic process | 66.6667 | 4 | yes |
| GO:0045907 | positive regulation of vasoconstriction | 66.6667 | 5 | yes |
| GO:0046395 | carboxylic acid catabolic process | 66.6667 | 5 | yes |
| GO:0046461 | neutral lipid catabolic process | 66.6667 | 5 | yes |
| GO:0046462 | monoacylglycerol metabolic process | 66.6667 | 6 | yes |
| GO:0046464 | acylglycerol catabolic process | 66.6667 | 6 | yes |
| GO:0046486 | glycerolipid metabolic process | 66.6667 | 4 | yes |
| GO:0046503 | glycerolipid catabolic process | 66.6667 | 5 | yes |
| GO:0052651 | monoacylglycerol catabolic process | 66.6667 | 7 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 66.6667 | 6 | yes |
| GO:0097746 | blood vessel diameter maintenance | 66.6667 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 66.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FAAH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| CP19A_HUMAN | [view interactions] | High throughput | no | no |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |