Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGF1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed, PubMed). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb . Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed, PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGF1_HUMAN
GO:0005158 insulin receptor binding 100.0000 4 yes
GO:0005159 insulin-like growth factor receptor binding 66.6667 4 yes
GO:0005179 hormone activity 66.6667 5 yes
GO:0008083 growth factor activity 66.6667 5 yes
GO:0048018 receptor ligand activity 66.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IGF1_HUMAN
GO:2000147 positive regulation of cell motility 100.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 100.0000 5 yes
GO:0023056 positive regulation of signaling 100.0000 4 yes
GO:0023057 negative regulation of signaling 100.0000 4 yes
GO:0030334 regulation of cell migration 100.0000 5 yes
GO:0030335 positive regulation of cell migration 100.0000 6 yes
GO:0031323 regulation of cellular metabolic process 100.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 100.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 100.0000 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 100.0000 6 yes
GO:0032101 regulation of response to external stimulus 100.0000 4 yes
GO:0040017 positive regulation of locomotion 100.0000 4 yes
GO:0042127 regulation of cell population proliferation 100.0000 4 yes
GO:0042981 regulation of apoptotic process 100.0000 5 yes
GO:0043066 negative regulation of apoptotic process 100.0000 6 yes
GO:0043067 regulation of programmed cell death 100.0000 4 yes
GO:0043069 negative regulation of programmed cell death 100.0000 5 yes
GO:0043408 regulation of MAPK cascade 100.0000 6 yes
GO:0043410 positive regulation of MAPK cascade 100.0000 7 yes
GO:0045787 positive regulation of cell cycle 100.0000 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 100.0000 5 yes
GO:0048009 insulin-like growth factor receptor signaling pathway 100.0000 6 yes
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0048584 positive regulation of response to stimulus 100.0000 4 yes
GO:0048585 negative regulation of response to stimulus 100.0000 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 100.0000 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 100.0000 6 yes
GO:0051094 positive regulation of developmental process 100.0000 4 yes
GO:0051128 regulation of cellular component organization 100.0000 4 yes
GO:0051130 positive regulation of cellular component organization 100.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 100.0000 4 yes
GO:0051726 regulation of cell cycle 100.0000 4 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 100.0000 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 100.0000 7 yes
GO:0060255 regulation of macromolecule metabolic process 100.0000 4 yes
GO:0071310 cellular response to organic substance 100.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 100.0000 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 100.0000 4 yes
GO:0080090 regulation of primary metabolic process 100.0000 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 100.0000 5 yes
GO:0080134 regulation of response to stress 100.0000 4 yes
GO:0090068 positive regulation of cell cycle process 100.0000 6 yes
GO:0008284 positive regulation of cell population proliferation 100.0000 5 yes
GO:0141124 intracellular signaling cassette 100.0000 4 yes
GO:0009889 regulation of biosynthetic process 100.0000 4 yes
GO:0009891 positive regulation of biosynthetic process 100.0000 5 yes
GO:0009893 positive regulation of metabolic process 100.0000 4 yes
GO:1901699 cellular response to nitrogen compound 100.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 100.0000 4 yes
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0009967 positive regulation of signal transduction 100.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 100.0000 5 yes
GO:0009968 negative regulation of signal transduction 100.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 100.0000 6 yes
GO:0010243 response to organonitrogen compound 100.0000 4 yes
GO:0010564 regulation of cell cycle process 100.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 100.0000 5 yes
GO:1904645 response to amyloid-beta 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:1904646 cellular response to amyloid-beta 100.0000 5 yes
GO:0010647 positive regulation of cell communication 100.0000 5 yes
GO:0010648 negative regulation of cell communication 100.0000 5 yes
GO:0010656 negative regulation of muscle cell apoptotic process 100.0000 7 yes
GO:0010660 regulation of muscle cell apoptotic process 100.0000 6 yes
GO:2000145 regulation of cell motility 100.0000 4 yes
GO:0010906 regulation of glucose metabolic process 66.6667 5 yes
GO:0010907 positive regulation of glucose metabolic process 66.6667 6 yes
GO:2000242 negative regulation of reproductive process 66.6667 4 yes
GO:0010962 regulation of glucan biosynthetic process 66.6667 7 yes
GO:2000677 regulation of transcription regulatory region DNA binding 66.6667 5 yes
GO:0014742 positive regulation of muscle hypertrophy 66.6667 5 yes
GO:2000679 positive regulation of transcription regulatory region DNA binding 66.6667 6 yes
GO:0014743 regulation of muscle hypertrophy 66.6667 6 yes
GO:2001141 regulation of RNA biosynthetic process 66.6667 6 yes
GO:0014896 muscle hypertrophy 66.6667 4 yes
GO:2001233 regulation of apoptotic signaling pathway 66.6667 5 yes
GO:0014904 myotube cell development 66.6667 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 66.6667 6 yes
GO:0014910 regulation of smooth muscle cell migration 66.6667 6 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 66.6667 6 yes
GO:0014911 positive regulation of smooth muscle cell migration 66.6667 7 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 66.6667 7 yes
GO:0019220 regulation of phosphate metabolic process 66.6667 6 yes
GO:0019752 carboxylic acid metabolic process 66.6667 5 yes
GO:0022407 regulation of cell-cell adhesion 66.6667 5 yes
GO:0022409 positive regulation of cell-cell adhesion 66.6667 6 yes
GO:0030155 regulation of cell adhesion 66.6667 4 yes
GO:0030166 proteoglycan biosynthetic process 66.6667 6 yes
GO:0030282 bone mineralization 66.6667 5 yes
GO:0030307 positive regulation of cell growth 66.6667 5 yes
GO:0030811 regulation of nucleotide catabolic process 66.6667 5 yes
GO:0030813 positive regulation of nucleotide catabolic process 66.6667 6 yes
GO:0031214 biomineral tissue development 66.6667 4 yes
GO:0031324 negative regulation of cellular metabolic process 66.6667 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 66.6667 6 yes
GO:0031329 regulation of cellular catabolic process 66.6667 5 yes
GO:0031331 positive regulation of cellular catabolic process 66.6667 6 yes
GO:0031347 regulation of defense response 66.6667 5 yes
GO:0031348 negative regulation of defense response 66.6667 5 yes
GO:0031399 regulation of protein modification process 66.6667 6 yes
GO:0031401 positive regulation of protein modification process 66.6667 7 yes
GO:0032102 negative regulation of response to external stimulus 66.6667 5 yes
GO:0032147 activation of protein kinase activity 66.6667 8 yes
GO:0032148 activation of protein kinase B activity 66.6667 9 yes
GO:0032651 regulation of interleukin-1 beta production 66.6667 6 yes
GO:0032652 regulation of interleukin-1 production 66.6667 5 yes
GO:0032680 regulation of tumor necrosis factor production 66.6667 6 yes
GO:0032691 negative regulation of interleukin-1 beta production 66.6667 7 yes
GO:0032692 negative regulation of interleukin-1 production 66.6667 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 66.6667 7 yes
GO:0032787 monocarboxylic acid metabolic process 66.6667 6 yes
GO:0032880 regulation of protein localization 66.6667 5 yes
GO:0032881 regulation of polysaccharide metabolic process 66.6667 5 yes
GO:0032885 regulation of polysaccharide biosynthetic process 66.6667 6 yes
GO:0032944 regulation of mononuclear cell proliferation 66.6667 6 yes
GO:0032946 positive regulation of mononuclear cell proliferation 66.6667 7 yes
GO:0033043 regulation of organelle organization 66.6667 5 yes
GO:0033121 regulation of purine nucleotide catabolic process 66.6667 6 yes
GO:0033123 positive regulation of purine nucleotide catabolic process 66.6667 7 yes
GO:0033674 positive regulation of kinase activity 66.6667 6 yes
GO:0034248 regulation of amide metabolic process 66.6667 4 yes
GO:0034249 negative regulation of amide metabolic process 66.6667 5 yes
GO:0034308 primary alcohol metabolic process 66.6667 4 yes
GO:0034391 regulation of smooth muscle cell apoptotic process 66.6667 7 yes
GO:0034392 negative regulation of smooth muscle cell apoptotic process 66.6667 8 yes
GO:0034762 regulation of transmembrane transport 66.6667 4 yes
GO:0034764 positive regulation of transmembrane transport 66.6667 5 yes
GO:0035630 bone mineralization involved in bone maturation 66.6667 6 yes
GO:0042060 wound healing 66.6667 4 yes
GO:0042102 positive regulation of T cell proliferation 66.6667 8 yes
GO:0042104 positive regulation of activated T cell proliferation 66.6667 9 yes
GO:0042129 regulation of T cell proliferation 66.6667 7 yes
GO:0042325 regulation of phosphorylation 66.6667 7 yes
GO:0042327 positive regulation of phosphorylation 66.6667 8 yes
GO:0042509 regulation of tyrosine phosphorylation of STAT protein 66.6667 9 yes
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 66.6667 10 yes
GO:0043085 positive regulation of catalytic activity 66.6667 4 yes
GO:0043255 regulation of carbohydrate biosynthetic process 66.6667 5 yes
GO:0043388 positive regulation of DNA binding 66.6667 5 yes
GO:0043436 oxoacid metabolic process 66.6667 4 yes
GO:0043467 regulation of generation of precursor metabolites and energy 66.6667 5 yes
GO:0043470 regulation of carbohydrate catabolic process 66.6667 5 yes
GO:0043502 regulation of muscle adaptation 66.6667 4 yes
GO:0043549 regulation of kinase activity 66.6667 5 yes
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 66.6667 5 yes
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 66.6667 6 yes
GO:0044057 regulation of system process 66.6667 4 yes
GO:0045445 myoblast differentiation 66.6667 4 yes
GO:0045595 regulation of cell differentiation 66.6667 4 yes
GO:0045596 negative regulation of cell differentiation 66.6667 5 yes
GO:0045597 positive regulation of cell differentiation 66.6667 5 yes
GO:0045667 regulation of osteoblast differentiation 66.6667 5 yes
GO:0045669 positive regulation of osteoblast differentiation 66.6667 6 yes
GO:0045725 positive regulation of glycogen biosynthetic process 66.6667 7 yes
GO:0045785 positive regulation of cell adhesion 66.6667 5 yes
GO:0045821 positive regulation of glycolytic process 66.6667 6 yes
GO:0045840 positive regulation of mitotic nuclear division 66.6667 7 yes
GO:0045859 regulation of protein kinase activity 66.6667 6 yes
GO:0045860 positive regulation of protein kinase activity 66.6667 7 yes
GO:0045893 positive regulation of DNA-templated transcription 66.6667 8 yes
GO:0045913 positive regulation of carbohydrate metabolic process 66.6667 5 yes
GO:0045927 positive regulation of growth 66.6667 4 yes
GO:0045937 positive regulation of phosphate metabolic process 66.6667 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 66.6667 9 yes
GO:0045981 positive regulation of nucleotide metabolic process 66.6667 6 yes
GO:0046006 regulation of activated T cell proliferation 66.6667 8 yes
GO:0046324 regulation of glucose import 66.6667 6 yes
GO:0046326 positive regulation of glucose import 66.6667 7 yes
GO:0046578 regulation of Ras protein signal transduction 66.6667 7 yes
GO:0046579 positive regulation of Ras protein signal transduction 66.6667 8 yes
GO:0046620 regulation of organ growth 66.6667 4 yes
GO:0046622 positive regulation of organ growth 66.6667 5 yes
GO:0048145 regulation of fibroblast proliferation 66.6667 5 yes
GO:0048146 positive regulation of fibroblast proliferation 66.6667 6 yes
GO:0048638 regulation of developmental growth 66.6667 4 yes
GO:0048639 positive regulation of developmental growth 66.6667 5 yes
GO:0048762 mesenchymal cell differentiation 66.6667 4 yes
GO:0050670 regulation of lymphocyte proliferation 66.6667 6 yes
GO:0050671 positive regulation of lymphocyte proliferation 66.6667 7 yes
GO:0050678 regulation of epithelial cell proliferation 66.6667 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 66.6667 6 yes
GO:0050708 regulation of protein secretion 66.6667 5 yes
GO:0050714 positive regulation of protein secretion 66.6667 6 yes
GO:0050727 regulation of inflammatory response 66.6667 5 yes
GO:0050728 negative regulation of inflammatory response 66.6667 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 66.6667 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 66.6667 9 yes
GO:0050821 protein stabilization 66.6667 4 yes
GO:0050848 regulation of calcium-mediated signaling 66.6667 6 yes
GO:0050850 positive regulation of calcium-mediated signaling 66.6667 7 yes
GO:0050863 regulation of T cell activation 66.6667 6 yes
GO:0050865 regulation of cell activation 66.6667 4 yes
GO:0050867 positive regulation of cell activation 66.6667 5 yes
GO:0050870 positive regulation of T cell activation 66.6667 7 yes
GO:0051046 regulation of secretion 66.6667 5 yes
GO:0051047 positive regulation of secretion 66.6667 5 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0051050 positive regulation of transport 66.6667 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 66.6667 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 66.6667 7 yes
GO:0051093 negative regulation of developmental process 66.6667 4 yes
GO:0051099 positive regulation of binding 66.6667 4 yes
GO:0051101 regulation of DNA binding 66.6667 4 yes
GO:0051129 negative regulation of cellular component organization 66.6667 5 yes
GO:0051147 regulation of muscle cell differentiation 66.6667 5 yes
GO:0051149 positive regulation of muscle cell differentiation 66.6667 6 yes
GO:0051153 regulation of striated muscle cell differentiation 66.6667 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 66.6667 7 yes
GO:0051174 regulation of phosphorus metabolic process 66.6667 5 yes
GO:0051222 positive regulation of protein transport 66.6667 5 yes
GO:0051223 regulation of protein transport 66.6667 5 yes
GO:0051241 negative regulation of multicellular organismal process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 66.6667 6 yes
GO:0051248 negative regulation of protein metabolic process 66.6667 6 yes
GO:0051249 regulation of lymphocyte activation 66.6667 5 yes
GO:0051251 positive regulation of lymphocyte activation 66.6667 6 yes
GO:0051252 regulation of RNA metabolic process 66.6667 5 yes
GO:0051254 positive regulation of RNA metabolic process 66.6667 6 yes
GO:0051338 regulation of transferase activity 66.6667 4 yes
GO:0051347 positive regulation of transferase activity 66.6667 5 yes
GO:0051783 regulation of nuclear division 66.6667 6 yes
GO:0051785 positive regulation of nuclear division 66.6667 7 yes
GO:0055001 muscle cell development 66.6667 4 yes
GO:0055021 regulation of cardiac muscle tissue growth 66.6667 6 yes
GO:0055023 positive regulation of cardiac muscle tissue growth 66.6667 7 yes
GO:0060281 regulation of oocyte development 66.6667 5 yes
GO:0060283 negative regulation of oocyte development 66.6667 5 yes
GO:0060284 regulation of cell development 66.6667 5 yes
GO:0001501 skeletal system development 66.6667 4 yes
GO:0060341 regulation of cellular localization 66.6667 4 yes
GO:0001558 regulation of cell growth 66.6667 4 yes
GO:0060420 regulation of heart growth 66.6667 5 yes
GO:0001817 regulation of cytokine production 66.6667 4 yes
GO:0060421 positive regulation of heart growth 66.6667 6 yes
GO:0001818 negative regulation of cytokine production 66.6667 5 yes
GO:0061050 regulation of cell growth involved in cardiac muscle cell development 66.6667 5 yes
GO:0001837 epithelial to mesenchymal transition 66.6667 5 yes
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 66.6667 6 yes
GO:0001932 regulation of protein phosphorylation 66.6667 7 yes
GO:0062012 regulation of small molecule metabolic process 66.6667 4 yes
GO:0001934 positive regulation of protein phosphorylation 66.6667 8 yes
GO:0062013 positive regulation of small molecule metabolic process 66.6667 5 yes
GO:0002684 positive regulation of immune system process 66.6667 4 yes
GO:0070201 regulation of establishment of protein localization 66.6667 6 yes
GO:0002694 regulation of leukocyte activation 66.6667 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 66.6667 7 yes
GO:0002696 positive regulation of leukocyte activation 66.6667 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 66.6667 8 yes
GO:0005979 regulation of glycogen biosynthetic process 66.6667 7 yes
GO:0070663 regulation of leukocyte proliferation 66.6667 5 yes
GO:0006029 proteoglycan metabolic process 66.6667 5 yes
GO:0070665 positive regulation of leukocyte proliferation 66.6667 6 yes
GO:0006109 regulation of carbohydrate metabolic process 66.6667 5 yes
GO:0070873 regulation of glycogen metabolic process 66.6667 6 yes
GO:0006110 regulation of glycolytic process 66.6667 6 yes
GO:0070875 positive regulation of glycogen metabolic process 66.6667 6 yes
GO:0006140 regulation of nucleotide metabolic process 66.6667 5 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 66.6667 8 yes
GO:0006355 regulation of DNA-templated transcription 66.6667 7 yes
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 66.6667 9 yes
GO:0006357 regulation of transcription by RNA polymerase II 66.6667 8 yes
GO:0007088 regulation of mitotic nuclear division 66.6667 6 yes
GO:0007264 small GTPase-mediated signal transduction 66.6667 5 yes
GO:0007265 Ras protein signal transduction 66.6667 6 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 66.6667 7 yes
GO:0007346 regulation of mitotic cell cycle 66.6667 5 yes
GO:0090201 negative regulation of release of cytochrome c from mitochondria 66.6667 7 yes
GO:0007517 muscle organ development 66.6667 4 yes
GO:0090257 regulation of muscle system process 66.6667 5 yes
GO:0106056 regulation of calcineurin-mediated signaling 66.6667 7 yes
GO:0009059 macromolecule biosynthetic process 66.6667 4 yes
GO:0106058 positive regulation of calcineurin-mediated signaling 66.6667 8 yes
GO:0009100 glycoprotein metabolic process 66.6667 4 yes
GO:0009101 glycoprotein biosynthetic process 66.6667 5 yes
GO:0150077 regulation of neuroinflammatory response 66.6667 6 yes
GO:0009441 glycolate metabolic process 66.6667 5 yes
GO:0150079 negative regulation of neuroinflammatory response 66.6667 7 yes
GO:1900542 regulation of purine nucleotide metabolic process 66.6667 6 yes
GO:0009890 negative regulation of biosynthetic process 66.6667 5 yes
GO:1900544 positive regulation of purine nucleotide metabolic process 66.6667 7 yes
GO:1901137 carbohydrate derivative biosynthetic process 66.6667 4 yes
GO:0009892 negative regulation of metabolic process 66.6667 4 yes
GO:1901566 organonitrogen compound biosynthetic process 66.6667 4 yes
GO:0009894 regulation of catabolic process 66.6667 4 yes
GO:0009896 positive regulation of catabolic process 66.6667 5 yes
GO:1902003 regulation of amyloid-beta formation 66.6667 5 yes
GO:1902430 negative regulation of amyloid-beta formation 66.6667 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 66.6667 7 yes
GO:0010468 regulation of gene expression 66.6667 6 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 66.6667 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 66.6667 5 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 66.6667 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 66.6667 6 yes
GO:1903018 regulation of glycoprotein metabolic process 66.6667 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 66.6667 6 yes
GO:1903020 positive regulation of glycoprotein metabolic process 66.6667 7 yes
GO:0010559 regulation of glycoprotein biosynthetic process 66.6667 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 66.6667 6 yes
GO:0010560 positive regulation of glycoprotein biosynthetic process 66.6667 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 66.6667 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 66.6667 6 yes
GO:1903530 regulation of secretion by cell 66.6667 4 yes
GO:1903532 positive regulation of secretion by cell 66.6667 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 66.6667 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 66.6667 5 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 66.6667 6 yes
GO:0010611 regulation of cardiac muscle hypertrophy 66.6667 5 yes
GO:1903578 regulation of ATP metabolic process 66.6667 7 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 66.6667 6 yes
GO:1903580 positive regulation of ATP metabolic process 66.6667 8 yes
GO:0010628 positive regulation of gene expression 66.6667 7 yes
GO:1903829 positive regulation of protein localization 66.6667 5 yes
GO:0010629 negative regulation of gene expression 66.6667 7 yes
GO:1904073 regulation of trophectodermal cell proliferation 66.6667 5 yes
GO:0010638 positive regulation of organelle organization 66.6667 6 yes
GO:1904075 positive regulation of trophectodermal cell proliferation 66.6667 6 yes
GO:0010639 negative regulation of organelle organization 66.6667 6 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 66.6667 6 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 66.6667 7 yes
GO:1904951 positive regulation of establishment of protein localization 66.6667 6 yes
GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 66.6667 8 yes
GO:0010721 negative regulation of cell development 66.6667 6 yes
GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process 66.6667 9 yes
GO:0010821 regulation of mitochondrion organization 66.6667 6 yes
GO:1905879 regulation of oogenesis 66.6667 4 yes
GO:0010827 regulation of glucose transmembrane transport 66.6667 5 yes
GO:2000026 regulation of multicellular organismal development 66.6667 4 yes
GO:0010828 positive regulation of glucose transmembrane transport 66.6667 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
GGYF1_HUMAN [view interactions] Low throughput no yes
IBP4_HUMAN [view interactions] Low throughput no no
IBP5_HUMAN [view interactions] Low throughput no no
IBP1_HUMAN [view interactions] Low throughput no no
INSR_HUMAN [view interactions] Low throughput no yes
IBP3_HUMAN [view interactions] Low throughput no no
IGSF1_HUMAN [view interactions] Low throughput no no
E2F1_HUMAN [view interactions] Low throughput no yes
ALS_HUMAN [view interactions] Low throughput no no
IBP7_HUMAN [view interactions] Low throughput no no
CCN3_HUMAN [view interactions] Low throughput no no
TRFE_HUMAN [view interactions] Low throughput no no
IDE_HUMAN [view interactions] Low throughput no yes
IBP2_HUMAN [view interactions] Low throughput no no
IGF1_HUMAN [view entry] [view interactions] Low throughput yes no
SOX4_HUMAN [view interactions] High throughput no yes
MESD_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
BANP_HUMAN [view interactions] High throughput no yes
TEANC_HUMAN [view interactions] High throughput no no
MKRN3_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes