IGF1_HUMAN
Evidence for PS localization
Functions
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed, PubMed). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb . Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed, PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
IGF1_HUMAN has binary interactions with 2 proteins
Isoforms
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in IGF1_HUMAN |
---|---|---|---|---|
GO:0005158 | insulin receptor binding | 100.0000 | 4 | yes |
GO:0005159 | insulin-like growth factor receptor binding | 66.6667 | 4 | yes |
GO:0005179 | hormone activity | 66.6667 | 5 | yes |
GO:0008083 | growth factor activity | 66.6667 | 5 | yes |
GO:0048018 | receptor ligand activity | 66.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in IGF1_HUMAN |
---|---|---|---|---|
GO:2000147 | positive regulation of cell motility | 100.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 100.0000 | 5 | yes |
GO:0023056 | positive regulation of signaling | 100.0000 | 4 | yes |
GO:0023057 | negative regulation of signaling | 100.0000 | 4 | yes |
GO:0030334 | regulation of cell migration | 100.0000 | 5 | yes |
GO:0030335 | positive regulation of cell migration | 100.0000 | 6 | yes |
GO:0031323 | regulation of cellular metabolic process | 100.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 100.0000 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 100.0000 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 100.0000 | 6 | yes |
GO:0032101 | regulation of response to external stimulus | 100.0000 | 4 | yes |
GO:0040017 | positive regulation of locomotion | 100.0000 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 100.0000 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 100.0000 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 100.0000 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 100.0000 | 4 | yes |
GO:0043069 | negative regulation of programmed cell death | 100.0000 | 5 | yes |
GO:0043408 | regulation of MAPK cascade | 100.0000 | 6 | yes |
GO:0043410 | positive regulation of MAPK cascade | 100.0000 | 7 | yes |
GO:0045787 | positive regulation of cell cycle | 100.0000 | 5 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 100.0000 | 5 | yes |
GO:0048009 | insulin-like growth factor receptor signaling pathway | 100.0000 | 6 | yes |
GO:0048522 | positive regulation of cellular process | 100.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 100.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 100.0000 | 4 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ALS_HUMAN | [view interactions] | Low throughput | no | no |
BANP_HUMAN | [view interactions] | High throughput | no | yes |
CCN3_HUMAN | [view interactions] | Low throughput | no | no |
E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
GGYF1_HUMAN | [view interactions] | Low throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
IBP1_HUMAN | [view interactions] | Low throughput | no | no |
IBP2_HUMAN | [view interactions] | Low throughput | no | no |
IBP3_HUMAN | [view interactions] | Low throughput | no | no |
IBP4_HUMAN | [view interactions] | Low throughput | no | no |
IBP5_HUMAN | [view interactions] | Low throughput | no | no |
IBP7_HUMAN | [view interactions] | Low throughput | no | no |
IDE_HUMAN | [view interactions] | Low throughput | no | yes |
IGF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IGSF1_HUMAN | [view interactions] | Low throughput | no | no |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
MESD_HUMAN | [view interactions] | High throughput | no | yes |
MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
SOX4_HUMAN | [view interactions] | High throughput | no | yes |
SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
TEANC_HUMAN | [view interactions] | High throughput | no | no |
TRFE_HUMAN | [view interactions] | Low throughput | no | no |