Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGF1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed, PubMed). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb . Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed, PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGF1_HUMAN
GO:0017076 purine nucleotide binding 40.0000 4 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 40.0000 5 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 36.6667 4 no
GO:0005524 ATP binding 36.6667 5 no
GO:0016301 kinase activity 36.6667 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 36.6667 4 no
GO:0030554 adenyl nucleotide binding 36.6667 5 no
GO:0032559 adenyl ribonucleotide binding 36.6667 5 no
GO:0001784 phosphotyrosine residue binding 30.0000 5 no
GO:0045309 protein phosphorylated amino acid binding 30.0000 4 no
GO:0004674 protein serine/threonine kinase activity 23.3333 4 no
GO:0106310 protein serine kinase activity 23.3333 4 no
GO:0045296 cadherin binding 23.3333 4 no
GO:0005159 insulin-like growth factor receptor binding 16.6667 4 yes
GO:0048018 receptor ligand activity 13.3333 4 yes
GO:0005179 hormone activity 10.0000 5 yes
GO:0008083 growth factor activity 6.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IGF1_HUMAN
GO:0010646 regulation of cell communication 96.6667 4 yes
GO:0048522 positive regulation of cellular process 93.3333 4 yes
GO:0048523 negative regulation of cellular process 93.3333 4 yes
GO:0009966 regulation of signal transduction 90.0000 4 yes
GO:0031323 regulation of cellular metabolic process 86.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 86.6667 4 yes
GO:0009893 positive regulation of metabolic process 86.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 83.3333 5 yes
GO:0080090 regulation of primary metabolic process 83.3333 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 76.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 76.6667 5 yes
GO:0023056 positive regulation of signaling 73.3333 4 yes
GO:0048584 positive regulation of response to stimulus 73.3333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 73.3333 5 yes
GO:0010468 regulation of gene expression 73.3333 5 yes
GO:0010647 positive regulation of cell communication 73.3333 5 yes
GO:0042127 regulation of cell population proliferation 70.0000 4 yes
GO:0051128 regulation of cellular component organization 70.0000 4 yes
GO:0009967 positive regulation of signal transduction 70.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 70.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 66.6667 6 yes
GO:0031326 regulation of cellular biosynthetic process 66.6667 5 yes
GO:0042325 regulation of phosphorylation 66.6667 7 yes
GO:0051174 regulation of phosphorus metabolic process 66.6667 5 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0009889 regulation of biosynthetic process 66.6667 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 63.3333 4 yes
GO:0071310 cellular response to organic substance 63.3333 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 63.3333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 60.0000 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 60.0000 6 yes
GO:0031399 regulation of protein modification process 60.0000 6 yes
GO:0042327 positive regulation of phosphorylation 60.0000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 60.0000 7 yes
GO:0051247 positive regulation of protein metabolic process 60.0000 6 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 60.0000 5 yes
GO:0008284 positive regulation of cell population proliferation 60.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 60.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 60.0000 6 yes
GO:0043085 positive regulation of catalytic activity 56.6667 4 yes
GO:0043408 regulation of MAPK cascade 56.6667 6 yes
GO:0051049 regulation of transport 56.6667 4 yes
GO:0001932 regulation of protein phosphorylation 56.6667 7 yes
GO:0010243 response to organonitrogen compound 56.6667 4 yes
GO:2000145 regulation of cell motility 53.3333 4 yes
GO:0023057 negative regulation of signaling 53.3333 4 yes
GO:0031401 positive regulation of protein modification process 53.3333 7 yes
GO:0043067 regulation of programmed cell death 53.3333 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 53.3333 6 yes
GO:0048585 negative regulation of response to stimulus 53.3333 4 yes
GO:0051338 regulation of transferase activity 53.3333 4 yes
GO:0060341 regulation of cellular localization 53.3333 4 yes
GO:0009892 negative regulation of metabolic process 53.3333 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 53.3333 6 yes
GO:1902533 positive regulation of intracellular signal transduction 53.3333 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 53.3333 5 yes
GO:0010648 negative regulation of cell communication 53.3333 5 yes
GO:0010941 regulation of cell death 53.3333 4 yes
GO:0042981 regulation of apoptotic process 50.0000 6 yes
GO:0051252 regulation of RNA metabolic process 50.0000 5 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0060548 negative regulation of cell death 50.0000 5 yes
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 yes
GO:2001141 regulation of RNA biosynthetic process 46.6667 6 yes
GO:0030334 regulation of cell migration 46.6667 5 yes
GO:0032880 regulation of protein localization 46.6667 5 yes
GO:0043066 negative regulation of apoptotic process 46.6667 7 yes
GO:0043069 negative regulation of programmed cell death 46.6667 6 yes
GO:0043410 positive regulation of MAPK cascade 46.6667 7 yes
GO:0045595 regulation of cell differentiation 46.6667 4 yes
GO:0051347 positive regulation of transferase activity 46.6667 5 yes
GO:0006355 regulation of DNA-templated transcription 46.6667 6 yes
GO:0071417 cellular response to organonitrogen compound 46.6667 4 yes
GO:0080134 regulation of response to stress 46.6667 4 yes
GO:0009968 negative regulation of signal transduction 46.6667 5 yes
GO:1901699 cellular response to nitrogen compound 46.6667 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 46.6667 7 yes
GO:0006796 phosphate-containing compound metabolic process 43.3333 4 no
GO:0070848 response to growth factor 43.3333 4 no
GO:0043549 regulation of kinase activity 43.3333 5 yes
GO:0045893 positive regulation of DNA-templated transcription 43.3333 7 yes
GO:0051254 positive regulation of RNA metabolic process 43.3333 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 43.3333 7 yes
GO:0010628 positive regulation of gene expression 43.3333 6 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 43.3333 8 yes
GO:2000147 positive regulation of cell motility 40.0000 5 yes
GO:0030335 positive regulation of cell migration 40.0000 6 yes
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 yes
GO:0036211 protein modification process 40.0000 4 no
GO:0043412 macromolecule modification 40.0000 4 no
GO:0033043 regulation of organelle organization 40.0000 5 yes
GO:0040017 positive regulation of locomotion 40.0000 4 yes
GO:0051130 positive regulation of cellular component organization 40.0000 5 yes
GO:0030155 regulation of cell adhesion 36.6667 4 yes
GO:0016310 phosphorylation 36.6667 5 no
GO:0071363 cellular response to growth factor stimulus 36.6667 5 no
GO:0033674 positive regulation of kinase activity 36.6667 6 yes
GO:0051094 positive regulation of developmental process 36.6667 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 36.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 36.6667 4 yes
GO:0002684 positive regulation of immune system process 36.6667 4 yes
GO:2000026 regulation of multicellular organismal development 36.6667 4 yes
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0045859 regulation of protein kinase activity 33.3333 6 yes
GO:0051050 positive regulation of transport 33.3333 4 yes
GO:0051093 negative regulation of developmental process 33.3333 4 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0051248 negative regulation of protein metabolic process 33.3333 6 yes
GO:2001233 regulation of apoptotic signaling pathway 30.0000 5 yes
GO:0022407 regulation of cell-cell adhesion 30.0000 5 yes
GO:0051052 regulation of DNA metabolic process 30.0000 5 no
GO:0008285 negative regulation of cell population proliferation 30.0000 5 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 30.0000 5 no
GO:0045785 positive regulation of cell adhesion 30.0000 5 yes
GO:0050865 regulation of cell activation 30.0000 4 yes
GO:0051223 regulation of protein transport 30.0000 5 yes
GO:0051726 regulation of cell cycle 30.0000 4 yes
GO:0070201 regulation of establishment of protein localization 30.0000 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 30.0000 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 30.0000 7 yes
GO:1901652 response to peptide 30.0000 4 yes
GO:0006915 apoptotic process 26.6667 4 no
GO:0018193 peptidyl-amino acid modification 26.6667 5 no
GO:0033993 response to lipid 26.6667 4 no
GO:0038127 ERBB signaling pathway 26.6667 6 no
GO:0043434 response to peptide hormone 26.6667 4 no
GO:0051054 positive regulation of DNA metabolic process 26.6667 6 no
GO:0080135 regulation of cellular response to stress 26.6667 4 no
GO:0016192 vesicle-mediated transport 26.6667 4 no
GO:0050776 regulation of immune response 26.6667 4 no
GO:0051493 regulation of cytoskeleton organization 26.6667 6 no
GO:0022607 cellular component assembly 26.6667 4 no
GO:0032386 regulation of intracellular transport 26.6667 5 no
GO:0071407 cellular response to organic cyclic compound 26.6667 5 no
GO:0045596 negative regulation of cell differentiation 26.6667 5 yes
GO:0045860 positive regulation of protein kinase activity 26.6667 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 26.6667 8 yes
GO:0050678 regulation of epithelial cell proliferation 26.6667 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 26.6667 6 yes
GO:0050863 regulation of T cell activation 26.6667 6 yes
GO:0051129 negative regulation of cellular component organization 26.6667 5 yes
GO:0051249 regulation of lymphocyte activation 26.6667 5 yes
GO:0060284 regulation of cell development 26.6667 5 yes
GO:0002694 regulation of leukocyte activation 26.6667 4 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 26.6667 8 yes
GO:1901653 cellular response to peptide 26.6667 5 yes
GO:0010629 negative regulation of gene expression 26.6667 6 yes
GO:0010638 positive regulation of organelle organization 26.6667 6 yes
GO:1903829 positive regulation of protein localization 26.6667 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 26.6667 6 yes
GO:2001234 negative regulation of apoptotic signaling pathway 23.3333 6 yes
GO:0006996 organelle organization 23.3333 4 no
GO:0007173 epidermal growth factor receptor signaling pathway 23.3333 7 no
GO:0008286 insulin receptor signaling pathway 23.3333 6 no
GO:0031667 response to nutrient levels 23.3333 4 no
GO:0032870 cellular response to hormone stimulus 23.3333 4 no
GO:0031347 regulation of defense response 23.3333 5 yes
GO:0048878 chemical homeostasis 23.3333 4 no
GO:0051345 positive regulation of hydrolase activity 23.3333 5 no
GO:0071375 cellular response to peptide hormone stimulus 23.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 23.3333 5 no
GO:0048732 gland development 23.3333 4 no
GO:0034248 regulation of cellular amide metabolic process 23.3333 5 yes
GO:0034330 cell junction organization 23.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 23.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 23.3333 4 no
GO:0034762 regulation of transmembrane transport 23.3333 4 yes
GO:0045597 positive regulation of cell differentiation 23.3333 5 yes
GO:0045927 positive regulation of growth 23.3333 4 yes
GO:0048015 phosphatidylinositol-mediated signaling 23.3333 5 yes
GO:0048017 inositol lipid-mediated signaling 23.3333 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 23.3333 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.3333 8 yes
GO:0051222 positive regulation of protein transport 23.3333 5 yes
GO:0000165 MAPK cascade 23.3333 4 yes
GO:0009894 regulation of catabolic process 23.3333 4 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 23.3333 6 yes
GO:1904951 positive regulation of establishment of protein localization 23.3333 6 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 20.0000 6 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 20.0000 7 yes
GO:0022409 positive regulation of cell-cell adhesion 20.0000 6 yes
GO:0031329 regulation of cellular catabolic process 20.0000 5 yes
GO:0032102 negative regulation of response to external stimulus 20.0000 5 yes
GO:0045787 positive regulation of cell cycle 20.0000 5 yes
GO:0046324 regulation of glucose import 20.0000 6 yes
GO:0048638 regulation of developmental growth 20.0000 4 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 20.0000 6 yes
GO:0050867 positive regulation of cell activation 20.0000 5 yes
GO:0050870 positive regulation of T cell activation 20.0000 7 yes
GO:0051251 positive regulation of lymphocyte activation 20.0000 6 yes
GO:0002696 positive regulation of leukocyte activation 20.0000 5 yes
GO:0070663 regulation of leukocyte proliferation 20.0000 5 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 20.0000 7 yes
GO:0010827 regulation of glucose transmembrane transport 20.0000 5 yes
GO:0014065 phosphatidylinositol 3-kinase signaling 20.0000 6 yes
GO:0031331 positive regulation of cellular catabolic process 16.6667 6 yes
GO:0031348 negative regulation of defense response 16.6667 5 yes
GO:0042060 wound healing 16.6667 4 yes
GO:0043467 regulation of generation of precursor metabolites and energy 16.6667 5 yes
GO:0048009 insulin-like growth factor receptor signaling pathway 16.6667 6 yes
GO:0048639 positive regulation of developmental growth 16.6667 5 yes
GO:0001558 regulation of cell growth 16.6667 4 yes
GO:0001817 regulation of cytokine production 16.6667 4 yes
GO:0006109 regulation of carbohydrate metabolic process 16.6667 5 yes
GO:0007264 small GTPase mediated signal transduction 16.6667 4 yes
GO:0007265 Ras protein signal transduction 16.6667 5 yes
GO:0007346 regulation of mitotic cell cycle 16.6667 5 yes
GO:0009896 positive regulation of catabolic process 16.6667 5 yes
GO:0010564 regulation of cell cycle process 16.6667 5 yes
GO:0010639 negative regulation of organelle organization 16.6667 6 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 16.6667 5 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 16.6667 6 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 16.6667 7 yes
GO:0014910 regulation of smooth muscle cell migration 13.3333 6 yes
GO:0014911 positive regulation of smooth muscle cell migration 13.3333 7 yes
GO:0030307 positive regulation of cell growth 13.3333 5 yes
GO:0032147 activation of protein kinase activity 13.3333 8 yes
GO:0032881 regulation of polysaccharide metabolic process 13.3333 5 yes
GO:0032885 regulation of polysaccharide biosynthetic process 13.3333 6 yes
GO:0032944 regulation of mononuclear cell proliferation 13.3333 6 yes
GO:0034764 positive regulation of transmembrane transport 13.3333 5 yes
GO:0042129 regulation of T cell proliferation 13.3333 7 yes
GO:0043255 regulation of carbohydrate biosynthetic process 13.3333 5 yes
GO:0043491 protein kinase B signaling 13.3333 4 yes
GO:0044057 regulation of system process 13.3333 4 yes
GO:0045913 positive regulation of carbohydrate metabolic process 13.3333 5 yes
GO:0046326 positive regulation of glucose import 13.3333 7 yes
GO:0050670 regulation of lymphocyte proliferation 13.3333 6 yes
GO:0050708 regulation of protein secretion 13.3333 5 yes
GO:0050727 regulation of inflammatory response 13.3333 5 yes
GO:0050728 negative regulation of inflammatory response 13.3333 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 13.3333 9 yes
GO:0051046 regulation of secretion 13.3333 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 13.3333 6 yes
GO:0062012 regulation of small molecule metabolic process 13.3333 4 yes
GO:0005979 regulation of glycogen biosynthetic process 13.3333 7 yes
GO:0062013 positive regulation of small molecule metabolic process 13.3333 5 yes
GO:0070371 ERK1 and ERK2 cascade 13.3333 5 yes
GO:0070665 positive regulation of leukocyte proliferation 13.3333 6 yes
GO:0070873 regulation of glycogen metabolic process 13.3333 6 yes
GO:1903530 regulation of secretion by cell 13.3333 4 yes
GO:0010676 positive regulation of cellular carbohydrate metabolic process 13.3333 6 yes
GO:0010721 negative regulation of cell development 13.3333 6 yes
GO:0010828 positive regulation of glucose transmembrane transport 13.3333 6 yes
GO:0010906 regulation of glucose metabolic process 13.3333 5 yes
GO:0010907 positive regulation of glucose metabolic process 13.3333 6 yes
GO:0010962 regulation of glucan biosynthetic process 13.3333 6 yes
GO:0032680 regulation of tumor necrosis factor production 10.0000 6 yes
GO:0040014 regulation of multicellular organism growth 10.0000 4 yes
GO:0045667 regulation of osteoblast differentiation 10.0000 5 yes
GO:0045669 positive regulation of osteoblast differentiation 10.0000 6 yes
GO:0045725 positive regulation of glycogen biosynthetic process 10.0000 7 yes
GO:0046578 regulation of Ras protein signal transduction 10.0000 7 yes
GO:0046620 regulation of organ growth 10.0000 4 yes
GO:0046622 positive regulation of organ growth 10.0000 5 yes
GO:0050821 protein stabilization 10.0000 4 yes
GO:0051047 positive regulation of secretion 10.0000 5 yes
GO:0070875 positive regulation of glycogen metabolic process 10.0000 6 yes
GO:0009059 macromolecule biosynthetic process 10.0000 4 yes
GO:0090068 positive regulation of cell cycle process 10.0000 6 yes
GO:1903532 positive regulation of secretion by cell 10.0000 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 10.0000 5 yes
GO:2000677 regulation of transcription regulatory region DNA binding 6.6667 5 yes
GO:2000679 positive regulation of transcription regulatory region DNA binding 6.6667 6 yes
GO:0032148 activation of protein kinase B activity 6.6667 9 yes
GO:0032651 regulation of interleukin-1 beta production 6.6667 6 yes
GO:0032652 regulation of interleukin-1 production 6.6667 5 yes
GO:0032691 negative regulation of interleukin-1 beta production 6.6667 7 yes
GO:0032692 negative regulation of interleukin-1 production 6.6667 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 6.6667 7 yes
GO:0032946 positive regulation of mononuclear cell proliferation 6.6667 7 yes
GO:0034249 negative regulation of cellular amide metabolic process 6.6667 6 yes
GO:0034645 cellular macromolecule biosynthetic process 6.6667 4 yes
GO:0042102 positive regulation of T cell proliferation 6.6667 8 yes
GO:0043388 positive regulation of DNA binding 6.6667 5 yes
GO:0048145 regulation of fibroblast proliferation 6.6667 5 yes
GO:0050671 positive regulation of lymphocyte proliferation 6.6667 7 yes
GO:0050714 positive regulation of protein secretion 6.6667 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 6.6667 7 yes
GO:0051099 positive regulation of binding 6.6667 4 yes
GO:0051101 regulation of DNA binding 6.6667 4 yes
GO:0055021 regulation of cardiac muscle tissue growth 6.6667 6 yes
GO:0055023 positive regulation of cardiac muscle tissue growth 6.6667 7 yes
GO:0001818 negative regulation of cytokine production 6.6667 5 yes
GO:0060420 regulation of heart growth 6.6667 5 yes
GO:0060421 positive regulation of heart growth 6.6667 6 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 6.6667 7 yes
GO:0090201 negative regulation of release of cytochrome c from mitochondria 6.6667 7 yes
GO:0090257 regulation of muscle system process 6.6667 5 yes
GO:1902003 regulation of amyloid-beta formation 6.6667 6 yes
GO:0010559 regulation of glycoprotein biosynthetic process 6.6667 6 yes
GO:1902430 negative regulation of amyloid-beta formation 6.6667 7 yes
GO:0010560 positive regulation of glycoprotein biosynthetic process 6.6667 7 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 6.6667 6 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 6.6667 7 yes
GO:1903018 regulation of glycoprotein metabolic process 6.6667 5 yes
GO:1903020 positive regulation of glycoprotein metabolic process 6.6667 6 yes
GO:0010656 negative regulation of muscle cell apoptotic process 6.6667 8 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 6.6667 6 yes
GO:0010660 regulation of muscle cell apoptotic process 6.6667 7 yes
GO:0010821 regulation of mitochondrion organization 6.6667 6 yes
GO:0010823 negative regulation of mitochondrion organization 6.6667 7 yes
GO:1904645 response to amyloid-beta 6.6667 5 yes
GO:1904646 cellular response to amyloid-beta 6.6667 6 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 6.6667 6 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 6.6667 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in IGF1_HUMAN
DOID:0050686 organ system cancer 6.6667 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
GGYF1_HUMAN [view interactions] Low throughput no yes
IBP4_HUMAN [view interactions] Low throughput no no
IBP5_HUMAN [view interactions] Low throughput no no
IBP1_HUMAN [view interactions] Low throughput no no
INSR_HUMAN [view interactions] Low throughput no yes
IBP3_HUMAN [view interactions] Low throughput no no
IGSF1_HUMAN [view interactions] Low throughput no no
E2F1_HUMAN [view interactions] Low throughput no yes
ALS_HUMAN [view interactions] Low throughput no no
IBP7_HUMAN [view interactions] Low throughput no no
CCN3_HUMAN [view interactions] Low throughput no no
TRFE_HUMAN [view interactions] Low throughput no no
IDE_HUMAN [view interactions] Low throughput no yes
IBP2_HUMAN [view interactions] Low throughput no no
SOX4_HUMAN [view interactions] High throughput no yes
MESD_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
BANP_HUMAN [view interactions] High throughput no yes
TEANC_HUMAN [view interactions] High throughput no no
MKRN3_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no
MMP1_HUMAN [view interactions] Computational no no
CILP1_HUMAN [view interactions] Computational no no
KLK3_HUMAN [view interactions] Computational no no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
ITAV_HUMAN [view interactions] Computational no yes
IRS2_HUMAN [view interactions] Computational no yes
GRB2_HUMAN [view entry] [view interactions] Computational yes yes
NCK2_HUMAN [view entry] [view interactions] Computational yes yes
BMP2_HUMAN [view interactions] Computational no no
EGF_HUMAN [view interactions] Computational no no
P85A_HUMAN [view interactions] Computational no yes
HSPB3_HUMAN [view interactions] Computational no no
CADH1_HUMAN [view entry] [view interactions] Computational yes no
RACK1_HUMAN [view interactions] Computational no yes
FGF2_HUMAN [view entry] [view interactions] Computational yes yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
BDNF_HUMAN [view interactions] Computational no yes
NTRK2_HUMAN [view entry] [view interactions] Computational yes yes
THRB_HUMAN [view interactions] Computational no no
TRPV2_HUMAN [view interactions] Computational no yes
VGFR2_HUMAN [view interactions] Computational no no
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
BCAR1_HUMAN [view interactions] Computational no yes
1433F_HUMAN [view entry] [view interactions] Computational yes yes
SMS_HUMAN [view entry] [view interactions] Computational yes no
GDF8_HUMAN [view interactions] Computational no no
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
PTN11_HUMAN [view entry] [view interactions] Computational yes yes
MET_HUMAN [view interactions] Computational no yes
CTF1_HUMAN [view interactions] Computational no no
PTN1_HUMAN [view interactions] Computational no yes
ITB3_HUMAN [view entry] [view interactions] Computational yes no
VTNC_HUMAN [view interactions] Computational no no
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
TKN1_HUMAN [view interactions] Computational no yes
LEP_HUMAN [view interactions] Computational no no
TGFA_HUMAN [view interactions] Computational no yes
GRAH_HUMAN [view interactions] Computational no no
FGF7_HUMAN [view interactions] Computational no no
SOM2_HUMAN [view interactions] Computational no no
CH3L1_HUMAN [view interactions] Computational no no
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
GRB10_HUMAN [view entry] [view interactions] Computational yes yes
FGF13_HUMAN [view interactions] Computational no no
IL6_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
PDGFD_HUMAN [view interactions] Computational no no
ESR2_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
CRK_HUMAN [view entry] [view interactions] Computational yes no
LX15B_HUMAN [view interactions] Computational no no
MMP2_HUMAN [view interactions] Computational no no
KLK13_HUMAN [view interactions] Computational no no
SLIB_HUMAN [view interactions] Computational no no
PAPP2_HUMAN [view interactions] Computational no no
LIF_HUMAN [view interactions] Computational no yes
PAXI_HUMAN [view interactions] Computational no yes
PDGFA_HUMAN [view interactions] Computational no yes
BMP7_HUMAN [view interactions] Computational no no
HGF_HUMAN [view interactions] Computational no yes
IRS1_HUMAN [view entry] [view interactions] Computational yes yes
NTRK1_HUMAN [view interactions] Computational no yes
KS6B1_HUMAN [view entry] [view interactions] Computational yes yes
FCGR1_HUMAN [view interactions] Computational no no
IBP6_HUMAN [view interactions] Computational no yes
PDGFC_HUMAN [view interactions] Computational no no
SOMA_HUMAN [view interactions] Computational no no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
SHBG_HUMAN [view interactions] Computational no no
ERBB2_HUMAN [view entry] [view interactions] Computational yes no
KLK1_HUMAN [view interactions] Computational no yes
MPRI_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
VGFR1_HUMAN [view interactions] Computational no no
ERBB3_HUMAN [view interactions] Computational no yes
INSRR_HUMAN [view interactions] Computational no no
PTHY_HUMAN [view interactions] Computational no no
ESR1_HUMAN [view interactions] Computational no no
PRL_HUMAN [view interactions] Computational no no
KPCD1_HUMAN [view interactions] Computational no yes
FINC_HUMAN [view interactions] Computational no yes
CATG_HUMAN [view interactions] Computational no no
IGF2_HUMAN [view interactions] Computational no no
KIT_HUMAN [view interactions] Computational no no
GHRL_HUMAN [view entry] [view interactions] Computational yes no
HBEGF_HUMAN [view interactions] Computational no no
PGS2_HUMAN [view interactions] Computational no no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
EGFR_HUMAN [view interactions] Computational no no
RAF1_HUMAN [view entry] [view interactions] Computational yes no
PAPP1_HUMAN [view interactions] Computational no no
PDGFB_HUMAN [view interactions] Computational no yes
KLK2_HUMAN [view interactions] Computational no no