Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGF1_HUMAN

GO
G2C
SynaptomeDB

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed, PubMed). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb . Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed, PubMed, PubMed, PubMed). [View more on UniProt]

020406080100120140160180
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%

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01002003004005006007008009001,0001,1001,2001,300
IGF1_HUMAN
LOADING 67%
020406080100120140160180
IGF1_HUMAN
LOADING 67%

IGF1_HUMAN has binary interactions with 2 proteins

IGF1_HUMANIGF1R_HUMANIGF1_HUMANIGF1_HUMANIGF1R_HUMANIGF1_HUMAN
Download full PS network for entry.
020406080100120140160180
Interacting regions
Canonical [IGF1_HUMAN]
Isoform [P05019-2] alignment
Isoform [P05019-3] alignment
Isoform [P05019-4] alignment
LOADING 89%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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