Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KBRS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KBRS1_HUMAN
GO:0003677 DNA binding 75.0000 4 no
GO:0003690 double-stranded DNA binding 75.0000 5 no
GO:0043565 sequence-specific DNA binding 75.0000 5 no
GO:1990837 sequence-specific double-stranded DNA binding 75.0000 6 no
GO:0042803 protein homodimerization activity 50.0000 4 no
GO:0016462 pyrophosphatase activity 50.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 yes
GO:0032555 purine ribonucleotide binding 50.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0031625 ubiquitin protein ligase binding 50.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 50.0000 4 no
GO:0000976 transcription cis-regulatory region binding 50.0000 5 no
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 50.0000 6 no
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 50.0000 7 no
GO:0000987 cis-regulatory region sequence-specific DNA binding 50.0000 6 no
GO:0001067 transcription regulatory region nucleic acid binding 50.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KBRS1_HUMAN
GO:0042981 regulation of apoptotic process 75.0000 6 no
GO:0043067 regulation of programmed cell death 75.0000 5 no
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0048584 positive regulation of response to stimulus 75.0000 4 no
GO:0050776 regulation of immune response 75.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 75.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 75.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 75.0000 4 no
GO:0051246 regulation of protein metabolic process 75.0000 5 no
GO:0051247 positive regulation of protein metabolic process 75.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 no
GO:0060548 negative regulation of cell death 75.0000 5 no
GO:0071310 cellular response to organic substance 75.0000 4 no
GO:0080090 regulation of primary metabolic process 75.0000 4 no
GO:0090304 nucleic acid metabolic process 75.0000 4 no
GO:0009966 regulation of signal transduction 75.0000 4 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0001817 regulation of cytokine production 75.0000 4 no
GO:0001819 positive regulation of cytokine production 75.0000 5 no
GO:0002684 positive regulation of immune system process 75.0000 4 no
GO:0009893 positive regulation of metabolic process 75.0000 4 no
GO:0010468 regulation of gene expression 75.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 75.0000 5 no
GO:0010628 positive regulation of gene expression 75.0000 6 no
GO:0010941 regulation of cell death 75.0000 4 no
GO:0032649 regulation of interferon-gamma production 50.0000 5 no
GO:0032655 regulation of interleukin-12 production 50.0000 5 no
GO:0032675 regulation of interleukin-6 production 50.0000 5 no
GO:0032729 positive regulation of interferon-gamma production 50.0000 6 no
GO:0032735 positive regulation of interleukin-12 production 50.0000 6 no
GO:0032755 positive regulation of interleukin-6 production 50.0000 6 no
GO:0043065 positive regulation of apoptotic process 50.0000 7 no
GO:0043066 negative regulation of apoptotic process 50.0000 7 no
GO:0043068 positive regulation of programmed cell death 50.0000 6 no
GO:0043069 negative regulation of programmed cell death 50.0000 6 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 50.0000 9 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 50.0000 8 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0045785 positive regulation of cell adhesion 50.0000 5 no
GO:0045862 positive regulation of proteolysis 50.0000 7 no
GO:0050778 positive regulation of immune response 50.0000 5 no
GO:0050865 regulation of cell activation 50.0000 4 no
GO:0050867 positive regulation of cell activation 50.0000 5 no
GO:0051336 regulation of hydrolase activity 50.0000 4 no
GO:0051345 positive regulation of hydrolase activity 50.0000 5 no
GO:0052547 regulation of peptidase activity 50.0000 5 no
GO:0052548 regulation of endopeptidase activity 50.0000 6 no
GO:0065003 protein-containing complex assembly 50.0000 5 no
GO:1903037 regulation of leukocyte cell-cell adhesion 50.0000 6 no
GO:1903039 positive regulation of leukocyte cell-cell adhesion 50.0000 7 no
GO:2000116 regulation of cysteine-type endopeptidase activity 50.0000 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 50.0000 8 no
GO:0000122 negative regulation of transcription by RNA polymerase II 50.0000 8 no
GO:0006355 regulation of DNA-templated transcription 50.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 50.0000 7 no
GO:0009416 response to light stimulus 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009890 negative regulation of biosynthetic process 50.0000 5 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010243 response to organonitrogen compound 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0016070 RNA metabolic process 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 50.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0031347 regulation of defense response 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0032101 regulation of response to external stimulus 50.0000 4 no
GO:0034097 response to cytokine 50.0000 4 no
GO:0034248 regulation of cellular amide metabolic process 50.0000 5 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0042176 regulation of protein catabolic process 50.0000 5 no
GO:0045892 negative regulation of DNA-templated transcription 50.0000 7 no
GO:0045893 positive regulation of DNA-templated transcription 50.0000 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 50.0000 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 50.0000 8 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0050727 regulation of inflammatory response 50.0000 5 no
GO:0051091 positive regulation of DNA-binding transcription factor activity 50.0000 4 no
GO:0051092 positive regulation of NF-kappaB transcription factor activity 50.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0051253 negative regulation of RNA metabolic process 50.0000 6 no
GO:0051254 positive regulation of RNA metabolic process 50.0000 6 no
GO:0007249 I-kappaB kinase/NF-kappaB signaling 50.0000 4 yes
GO:0070555 response to interleukin-1 50.0000 5 no
GO:0070848 response to growth factor 50.0000 4 no
GO:0048878 chemical homeostasis 50.0000 4 yes
GO:0071363 cellular response to growth factor stimulus 50.0000 5 no
GO:0071417 cellular response to organonitrogen compound 50.0000 4 no
GO:0002221 pattern recognition receptor signaling pathway 50.0000 4 no
GO:0080134 regulation of response to stress 50.0000 4 no
GO:1901222 regulation of NIK/NF-kappaB signaling 50.0000 6 no
GO:1901224 positive regulation of NIK/NF-kappaB signaling 50.0000 7 no
GO:1901652 response to peptide 50.0000 4 no
GO:1901653 cellular response to peptide 50.0000 5 no
GO:1901699 cellular response to nitrogen compound 50.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 50.0000 7 no
GO:1902680 positive regulation of RNA biosynthetic process 50.0000 7 no
GO:1902893 regulation of miRNA transcription 50.0000 7 no
GO:1902894 negative regulation of miRNA transcription 50.0000 8 no
GO:1902991 regulation of amyloid precursor protein catabolic process 50.0000 6 no
GO:1902993 positive regulation of amyloid precursor protein catabolic process 50.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 50.0000 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 50.0000 8 no
GO:1903508 positive regulation of nucleic acid-templated transcription 50.0000 8 no
GO:2000628 regulation of miRNA metabolic process 50.0000 6 no
GO:2000629 negative regulation of miRNA metabolic process 50.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0010942 positive regulation of cell death 50.0000 5 no
GO:0010950 positive regulation of endopeptidase activity 50.0000 7 no
GO:0010952 positive regulation of peptidase activity 50.0000 6 no
GO:0022407 regulation of cell-cell adhesion 50.0000 5 no
GO:0022409 positive regulation of cell-cell adhesion 50.0000 6 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0030155 regulation of cell adhesion 50.0000 4 no
GO:0030162 regulation of proteolysis 50.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IKBB_HUMAN [view interactions] Low throughput no no
SLAF1_HUMAN [view interactions] High throughput no no
ARL4C_HUMAN [view interactions] High throughput no yes
CBLN4_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC2_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
ACVR1_HUMAN [view interactions] High throughput no yes
BMR1B_HUMAN [view interactions] High throughput no no
SMUF2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
LCN9_HUMAN [view interactions] High throughput no no
NAA30_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
PAEP_HUMAN [view interactions] High throughput no no
MAGT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
IKBA_HUMAN [view interactions] Computational no yes
NFKB2_HUMAN [view interactions] Computational no yes
NFKB1_HUMAN [view interactions] Computational no yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes