KCNT1_HUMAN
Evidence for PS localization
Functions
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 379 | Arg | Gln | Epilepsy,nocturnalfrontallobe,5(ENFL5) | - |
| 409 | Arg | Gln | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 455 | Arg | His | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 741 | Ile | Met | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 777 | Tyr | His | Epilepsy,nocturnalfrontallobe,5(ENFL5) | - |
| 877 | Met | Ile | Epilepsy,nocturnalfrontallobe,5(ENFL5) | - |
| 909 | Arg | Cys | Epilepsy,nocturnalfrontallobe,5(ENFL5) | - |
| 915 | Ala | Thr | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 497 | Met | Val | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 928 | Lys | Glu | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 269 | Gly | Ser | Developmentalandepilepticencephalopathy14(DEE14) | - |
| 947 | Ala | Thr | Developmentalandepilepticencephalopathy14(DEE14) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCNT1_HUMAN |
|---|---|---|---|---|
| GO:0005267 | potassium channel activity | 66.6667 | 6 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015267 | channel activity | 66.6667 | 4 | yes |
| GO:0015271 | outward rectifier potassium channel activity | 66.6667 | 8 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 66.6667 | 5 | yes |
| GO:0022832 | voltage-gated channel activity | 66.6667 | 6 | yes |
| GO:0022834 | ligand-gated channel activity | 66.6667 | 6 | yes |
| GO:0022836 | gated channel activity | 66.6667 | 5 | yes |
| GO:0022839 | monoatomic ion-gated channel activity | 66.6667 | 7 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 66.6667 | 6 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 66.6667 | 6 | yes |
| GO:0005216 | monoatomic ion channel activity | 66.6667 | 4 | yes |
| GO:0005228 | intracellular sodium-activated potassium channel activity | 66.6667 | 7 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 66.6667 | 5 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 66.6667 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 66.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCNT1_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 66.6667 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 66.6667 | 5 | yes |
| GO:0006813 | potassium ion transport | 66.6667 | 7 | yes |
| GO:0030001 | metal ion transport | 66.6667 | 6 | yes |
| GO:0071805 | potassium ion transmembrane transport | 66.6667 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 66.6667 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 66.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |