Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NAPEP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed, PubMed, PubMed, PubMed). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain . May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation . As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NAPEP_HUMAN
GO:0042578 phosphoric ester hydrolase activity 75.0000 4 yes
GO:0043169 cation binding 75.0000 4 yes
GO:0046872 metal ion binding 75.0000 5 yes
GO:0004620 phospholipase activity 50.0000 5 yes
GO:0008081 phosphoric diester hydrolase activity 50.0000 5 yes
GO:0008270 zinc ion binding 50.0000 7 yes
GO:0016298 lipase activity 50.0000 4 yes
GO:0031406 carboxylic acid binding 50.0000 4 yes
GO:0032052 bile acid binding 50.0000 6 yes
GO:0033293 monocarboxylic acid binding 50.0000 5 yes
GO:0043168 anion binding 50.0000 4 yes
GO:0046914 transition metal ion binding 50.0000 6 yes
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity 50.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NAPEP_HUMAN
GO:0045595 regulation of cell differentiation 100.0000 4 yes
GO:0045597 positive regulation of cell differentiation 100.0000 5 yes
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0051094 positive regulation of developmental process 100.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 75.0000 4 yes
GO:0048584 positive regulation of response to stimulus 75.0000 4 yes
GO:0001523 retinoid metabolic process 50.0000 7 yes
GO:0006576 biogenic amine metabolic process 50.0000 5 yes
GO:0006644 phospholipid metabolic process 50.0000 4 yes
GO:0006650 glycerophospholipid metabolic process 50.0000 5 yes
GO:0006720 isoprenoid metabolic process 50.0000 4 yes
GO:0006721 terpenoid metabolic process 50.0000 5 yes
GO:0009308 amine metabolic process 50.0000 4 yes
GO:0009395 phospholipid catabolic process 50.0000 5 yes
GO:0016042 lipid catabolic process 50.0000 4 yes
GO:0016101 diterpenoid metabolic process 50.0000 6 yes
GO:0031347 regulation of defense response 50.0000 5 yes
GO:0031349 positive regulation of defense response 50.0000 5 yes
GO:0032101 regulation of response to external stimulus 50.0000 4 yes
GO:0032103 positive regulation of response to external stimulus 50.0000 5 yes
GO:0034308 primary alcohol metabolic process 50.0000 4 yes
GO:0042439 ethanolamine-containing compound metabolic process 50.0000 4 yes
GO:0044242 cellular lipid catabolic process 50.0000 4 yes
GO:0045598 regulation of fat cell differentiation 50.0000 5 yes
GO:0045600 positive regulation of fat cell differentiation 50.0000 6 yes
GO:0046337 phosphatidylethanolamine metabolic process 50.0000 6 yes
GO:0046434 organophosphate catabolic process 50.0000 4 yes
GO:0046486 glycerolipid metabolic process 50.0000 4 yes
GO:0048874 host-mediated regulation of intestinal microbiota composition 50.0000 4 yes
GO:0050727 regulation of inflammatory response 50.0000 5 yes
GO:0050729 positive regulation of inflammatory response 50.0000 6 yes
GO:0051851 modulation by host of symbiont process 50.0000 4 yes
GO:0070291 N-acylethanolamine metabolic process 50.0000 5 yes
GO:0080134 regulation of response to stress 50.0000 4 yes
GO:0090335 regulation of brown fat cell differentiation 50.0000 6 yes
GO:0090336 positive regulation of brown fat cell differentiation 50.0000 7 yes
GO:0008284 positive regulation of cell population proliferation 50.0000 5 no
GO:0010720 positive regulation of cell development 50.0000 6 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0050767 regulation of neurogenesis 50.0000 6 no
GO:0050769 positive regulation of neurogenesis 50.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 no
GO:0051960 regulation of nervous system development 50.0000 5 no
GO:0051962 positive regulation of nervous system development 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0060284 regulation of cell development 50.0000 5 no
GO:2000026 regulation of multicellular organismal development 50.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NAPEP_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
CLC4M_HUMAN [view interactions] High throughput no no