NCKX2_HUMAN
Evidence for PS localization
Functions
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed, PubMed). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NCKX2_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 66.6667 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 66.6667 | 5 | yes |
| GO:0005262 | calcium channel activity | 66.6667 | 6 | yes |
| GO:0005432 | calcium:sodium antiporter activity | 66.6667 | 7 | yes |
| GO:0008273 | calcium, potassium:sodium antiporter activity | 66.6667 | 7 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015267 | channel activity | 66.6667 | 4 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015293 | symporter activity | 66.6667 | 5 | yes |
| GO:0015297 | antiporter activity | 66.6667 | 5 | yes |
| GO:0015368 | calcium:monoatomic cation antiporter activity | 66.6667 | 6 | yes |
| GO:0022821 | solute:potassium antiporter activity | 66.6667 | 6 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0140828 | metal cation:monoatomic cation antiporter activity | 66.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NCKX2_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 66.6667 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 66.6667 | 5 | yes |
| GO:0006813 | potassium ion transport | 66.6667 | 7 | yes |
| GO:0006814 | sodium ion transport | 66.6667 | 7 | yes |
| GO:0006816 | calcium ion transport | 66.6667 | 7 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 66.6667 | 4 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 66.6667 | 5 | yes |
| GO:0007612 | learning | 66.6667 | 4 | yes |
| GO:0007613 | memory | 66.6667 | 4 | yes |
| GO:0009416 | response to light stimulus | 66.6667 | 4 | yes |
| GO:0009583 | detection of light stimulus | 66.6667 | 4 | yes |
| GO:0009642 | response to light intensity | 66.6667 | 5 | yes |
| GO:0009644 | response to high light intensity | 66.6667 | 6 | yes |
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 66.6667 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 66.6667 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 66.6667 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 66.6667 | 4 | yes |
| GO:0030001 | metal ion transport | 66.6667 | 6 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 66.6667 | 5 | yes |
| GO:0035725 | sodium ion transmembrane transport | 66.6667 | 5 | yes |
| GO:0036368 | cone photoresponse recovery | 66.6667 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 66.6667 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 66.6667 | 5 | yes |
| GO:0050890 | cognition | 66.6667 | 4 | yes |
| GO:0055074 | calcium ion homeostasis | 66.6667 | 4 | yes |
| GO:0055080 | monoatomic cation homeostasis | 66.6667 | 4 | yes |
| GO:0060291 | long-term synaptic potentiation | 66.6667 | 4 | yes |
| GO:0060292 | long-term synaptic depression | 66.6667 | 4 | yes |
| GO:0070509 | calcium ion import | 66.6667 | 8 | yes |
| GO:0070588 | calcium ion transmembrane transport | 66.6667 | 5 | yes |
| GO:0071478 | cellular response to radiation | 66.6667 | 4 | yes |
| GO:0071482 | cellular response to light stimulus | 66.6667 | 5 | yes |
| GO:0071484 | cellular response to light intensity | 66.6667 | 6 | yes |
| GO:0071486 | cellular response to high light intensity | 66.6667 | 7 | yes |
| GO:0071805 | potassium ion transmembrane transport | 66.6667 | 5 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 66.6667 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 66.6667 | 4 | yes |
| GO:0098657 | import into cell | 66.6667 | 4 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 66.6667 | 5 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 66.6667 | 4 | yes |
| GO:0098703 | calcium ion import across plasma membrane | 66.6667 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 66.6667 | 4 | yes |
| GO:1902656 | calcium ion import into cytosol | 66.6667 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCKX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |