Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

UBP6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in UBP6_HUMAN
GO:0019900 kinase binding 53.8462 4 no
GO:0019901 protein kinase binding 53.8462 5 no
GO:0043169 cation binding 38.4615 4 no
GO:0046872 metal ion binding 38.4615 5 no
GO:0000166 nucleotide binding 38.4615 4 no
GO:0017076 purine nucleotide binding 38.4615 5 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 no
GO:0043168 anion binding 38.4615 4 no
GO:0003924 GTPase activity 30.7692 7 no
GO:0005525 GTP binding 30.7692 5 no
GO:0016462 pyrophosphatase activity 30.7692 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.7692 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.7692 6 no
GO:0019001 guanyl nucleotide binding 30.7692 6 no
GO:0032561 guanyl ribonucleotide binding 30.7692 5 no
GO:0005509 calcium ion binding 23.0769 6 no
GO:0010853 cyclase activator activity 23.0769 4 no
GO:0010854 adenylate cyclase regulator activity 23.0769 4 no
GO:0010856 adenylate cyclase activator activity 23.0769 5 no
GO:0019209 kinase activator activity 23.0769 4 no
GO:0019211 phosphatase activator activity 23.0769 4 no
GO:0019887 protein kinase regulator activity 23.0769 4 no
GO:0019888 protein phosphatase regulator activity 23.0769 4 no
GO:0030295 protein kinase activator activity 23.0769 5 no
GO:0031432 titin binding 23.0769 4 no
GO:0043539 protein serine/threonine kinase activator activity 23.0769 6 no
GO:0072542 protein phosphatase activator activity 23.0769 5 no
GO:0031996 thioesterase binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in UBP6_HUMAN
GO:0048522 positive regulation of cellular process 84.6154 4 no
GO:0080090 regulation of primary metabolic process 76.9231 4 no
GO:0009893 positive regulation of metabolic process 76.9231 4 no
GO:0009966 regulation of signal transduction 76.9231 4 no
GO:0010604 positive regulation of macromolecule metabolic process 76.9231 5 no
GO:0010646 regulation of cell communication 76.9231 4 no
GO:0048523 negative regulation of cellular process 76.9231 4 no
GO:0060255 regulation of macromolecule metabolic process 76.9231 4 no
GO:1902531 regulation of intracellular signal transduction 69.2308 5 no
GO:0051049 regulation of transport 61.5385 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0051246 regulation of protein metabolic process 61.5385 5 no
GO:0051247 positive regulation of protein metabolic process 61.5385 6 no
GO:0009892 negative regulation of metabolic process 53.8462 4 no
GO:0010605 negative regulation of macromolecule metabolic process 53.8462 5 no
GO:0031324 negative regulation of cellular metabolic process 53.8462 5 no
GO:0031325 positive regulation of cellular metabolic process 53.8462 5 no
GO:0141124 intracellular signaling cassette 46.1538 4 no
GO:0006996 organelle organization 46.1538 4 no
GO:0007010 cytoskeleton organization 46.1538 5 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0030030 cell projection organization 46.1538 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0051130 positive regulation of cellular component organization 46.1538 5 no
GO:0120036 plasma membrane bounded cell projection organization 46.1538 5 no
GO:0001932 regulation of protein phosphorylation 46.1538 7 no
GO:0001934 positive regulation of protein phosphorylation 46.1538 8 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0010562 positive regulation of phosphorus metabolic process 46.1538 6 no
GO:0010564 regulation of cell cycle process 46.1538 5 no
GO:0010647 positive regulation of cell communication 46.1538 5 no
GO:0019220 regulation of phosphate metabolic process 46.1538 6 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:0031399 regulation of protein modification process 46.1538 6 no
GO:0031401 positive regulation of protein modification process 46.1538 7 no
GO:0042325 regulation of phosphorylation 46.1538 7 no
GO:0042327 positive regulation of phosphorylation 46.1538 8 no
GO:0045937 positive regulation of phosphate metabolic process 46.1538 7 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 no
GO:0051726 regulation of cell cycle 46.1538 4 no
GO:0006915 apoptotic process 38.4615 4 no
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0000086 G2/M transition of mitotic cell cycle 38.4615 5 no
GO:0032465 regulation of cytokinesis 38.4615 5 no
GO:0044772 mitotic cell cycle phase transition 38.4615 4 no
GO:0044839 cell cycle G2/M phase transition 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0051051 negative regulation of transport 38.4615 4 no
GO:0051302 regulation of cell division 38.4615 4 no
GO:0009890 negative regulation of biosynthetic process 30.7692 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0031327 negative regulation of cellular biosynthetic process 30.7692 6 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0008104 protein localization 30.7692 4 no
GO:0010638 positive regulation of organelle organization 30.7692 6 no
GO:0030031 cell projection assembly 30.7692 5 no
GO:0030334 regulation of cell migration 30.7692 5 no
GO:0030335 positive regulation of cell migration 30.7692 6 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0031346 positive regulation of cell projection organization 30.7692 6 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0040017 positive regulation of locomotion 30.7692 4 no
GO:0044087 regulation of cellular component biogenesis 30.7692 4 no
GO:0050807 regulation of synapse organization 30.7692 5 no
GO:0120031 plasma membrane bounded cell projection assembly 30.7692 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:1902903 regulation of supramolecular fiber organization 30.7692 5 no
GO:1902905 positive regulation of supramolecular fiber organization 30.7692 6 no
GO:2000145 regulation of cell motility 30.7692 4 no
GO:2000147 positive regulation of cell motility 30.7692 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0045595 regulation of cell differentiation 30.7692 4 no
GO:0006508 proteolysis 30.7692 4 yes
GO:0036211 protein modification process 30.7692 4 yes
GO:0043412 macromolecule modification 30.7692 4 yes
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 yes
GO:0010799 regulation of peptidyl-threonine phosphorylation 30.7692 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 30.7692 9 no
GO:0021762 substantia nigra development 30.7692 4 no
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 30.7692 5 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0044057 regulation of system process 30.7692 4 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0050848 regulation of calcium-mediated signaling 30.7692 6 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 23.0769 8 no
GO:0090257 regulation of muscle system process 23.0769 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 23.0769 6 no
GO:1903169 regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1903522 regulation of blood circulation 23.0769 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 23.0769 6 no
GO:1904063 negative regulation of cation transmembrane transport 23.0769 7 no
GO:1904064 positive regulation of cation transmembrane transport 23.0769 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 23.0769 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 23.0769 8 no
GO:2001257 regulation of cation channel activity 23.0769 6 no
GO:2001258 negative regulation of cation channel activity 23.0769 6 no
GO:2001259 positive regulation of cation channel activity 23.0769 6 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0019941 modification-dependent protein catabolic process 23.0769 6 no
GO:0043632 modification-dependent macromolecule catabolic process 23.0769 5 no
GO:0051603 proteolysis involved in protein catabolic process 23.0769 5 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0048732 gland development 23.0769 4 no
GO:0030100 regulation of endocytosis 23.0769 5 no
GO:0032956 regulation of actin cytoskeleton organization 23.0769 5 no
GO:0032970 regulation of actin filament-based process 23.0769 4 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0044089 positive regulation of cellular component biogenesis 23.0769 5 no
GO:0050808 synapse organization 23.0769 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.0769 6 no
GO:0051093 negative regulation of developmental process 23.0769 4 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0051495 positive regulation of cytoskeleton organization 23.0769 7 no
GO:0060491 regulation of cell projection assembly 23.0769 5 no
GO:0098657 import into cell 23.0769 4 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 23.0769 6 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:0007264 small GTPase-mediated signal transduction 23.0769 5 no
GO:0010629 negative regulation of gene expression 23.0769 7 no
GO:0010810 regulation of cell-substrate adhesion 23.0769 5 no
GO:0010811 positive regulation of cell-substrate adhesion 23.0769 6 no
GO:0016055 Wnt signaling pathway 23.0769 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0030155 regulation of cell adhesion 23.0769 4 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0045785 positive regulation of cell adhesion 23.0769 5 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0007346 regulation of mitotic cell cycle 23.0769 5 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0045787 positive regulation of cell cycle 23.0769 5 no
GO:0090068 positive regulation of cell cycle process 23.0769 6 no
GO:0009894 regulation of catabolic process 23.0769 4 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0010720 positive regulation of cell development 23.0769 6 no
GO:0043393 regulation of protein binding 23.0769 4 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0001933 negative regulation of protein phosphorylation 23.0769 8 no
GO:0005513 detection of calcium ion 23.0769 4 no
GO:0006937 regulation of muscle contraction 23.0769 6 no
GO:0006942 regulation of striated muscle contraction 23.0769 7 no
GO:0008016 regulation of heart contraction 23.0769 6 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0010563 negative regulation of phosphorus metabolic process 23.0769 6 no
GO:0010649 regulation of cell communication by electrical coupling 23.0769 5 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 23.0769 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23.0769 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 23.0769 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 23.0769 6 no
GO:0010921 regulation of phosphatase activity 23.0769 5 no
GO:0010922 positive regulation of phosphatase activity 23.0769 6 no
GO:0010959 regulation of metal ion transport 23.0769 6 no
GO:0019722 calcium-mediated signaling 23.0769 5 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0031952 regulation of protein autophosphorylation 23.0769 8 no
GO:0031954 positive regulation of protein autophosphorylation 23.0769 9 no
GO:0032410 negative regulation of transporter activity 23.0769 4 no
GO:0032411 positive regulation of transporter activity 23.0769 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 23.0769 7 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0034097 response to cytokine 23.0769 4 no
GO:0034763 negative regulation of transmembrane transport 23.0769 5 no
GO:0034764 positive regulation of transmembrane transport 23.0769 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.0769 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 23.0769 6 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 23.0769 6 no
GO:0035303 regulation of dephosphorylation 23.0769 7 no
GO:0035304 regulation of protein dephosphorylation 23.0769 7 no
GO:0035306 positive regulation of dephosphorylation 23.0769 8 no
GO:0035307 positive regulation of protein dephosphorylation 23.0769 8 no
GO:0042326 negative regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0043269 regulation of monoatomic ion transport 23.0769 5 no
GO:0043270 positive regulation of monoatomic ion transport 23.0769 5 no
GO:0043271 negative regulation of monoatomic ion transport 23.0769 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 23.0769 6 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0045936 negative regulation of phosphate metabolic process 23.0769 7 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 23.0769 5 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 23.0769 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 23.0769 6 no
GO:0051282 regulation of sequestering of calcium ion 23.0769 4 no
GO:0051284 positive regulation of sequestering of calcium ion 23.0769 5 no
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 23.0769 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 23.0769 6 no
GO:0051345 positive regulation of hydrolase activity 23.0769 5 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0051592 response to calcium ion 23.0769 5 no
GO:0051924 regulation of calcium ion transport 23.0769 7 no
GO:0051926 negative regulation of calcium ion transport 23.0769 6 no
GO:0051928 positive regulation of calcium ion transport 23.0769 6 no
GO:0055117 regulation of cardiac muscle contraction 23.0769 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 23.0769 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 23.0769 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 23.0769 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 23.0769 7 no
GO:0043687 post-translational protein modification 15.3846 5 yes
GO:0070647 protein modification by small protein conjugation or removal 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ANR44_HUMAN [view interactions] Low throughput no no
MLRV_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
KLF4_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK1_HUMAN [view interactions] Low throughput no yes
UBP32_HUMAN [view interactions] High throughput no yes
AT7L3_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
RB33B_HUMAN [view interactions] High throughput no no
EXOS8_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
ZNF76_HUMAN [view interactions] High throughput no no
RIPP1_HUMAN [view interactions] High throughput no no
ANR11_HUMAN [view interactions] High throughput no yes
CABP2_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes