Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRYM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
314 Lys Thr Deafness,autosomaldominant,40(DFNA40) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CRYM_HUMAN
GO:0042803 protein homodimerization activity 37.5000 4 yes
GO:0019900 kinase binding 37.5000 4 no
GO:0019902 phosphatase binding 37.5000 4 no
GO:0019903 protein phosphatase binding 37.5000 5 no
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 25.0000 4 yes
GO:0047127 thiomorpholine-carboxylate dehydrogenase activity 25.0000 5 yes
GO:0050661 NADP binding 25.0000 4 yes
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030165 PDZ domain binding 25.0000 4 no
GO:0035254 glutamate receptor binding 25.0000 4 no
GO:0035255 ionotropic glutamate receptor binding 25.0000 5 no
GO:0050780 dopamine receptor binding 25.0000 5 no
GO:0008157 protein phosphatase 1 binding 25.0000 6 no
GO:0046872 metal ion binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CRYM_HUMAN
GO:0031323 regulation of cellular metabolic process 100.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 87.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 87.5000 4 yes
GO:0080090 regulation of primary metabolic process 87.5000 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0043933 protein-containing complex organization 62.5000 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051246 regulation of protein metabolic process 62.5000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0006355 regulation of DNA-templated transcription 37.5000 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 37.5000 7 yes
GO:0009892 negative regulation of metabolic process 37.5000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 yes
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 yes
GO:0051252 regulation of RNA metabolic process 37.5000 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 37.5000 7 yes
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0008104 protein localization 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:1990778 protein localization to cell periphery 37.5000 5 no
GO:0031329 regulation of cellular catabolic process 37.5000 5 no
GO:0022411 cellular component disassembly 37.5000 4 no
GO:0032984 protein-containing complex disassembly 37.5000 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 25.0000 8 yes
GO:0006553 lysine metabolic process 25.0000 6 yes
GO:0006554 lysine catabolic process 25.0000 5 yes
GO:0007600 sensory perception 25.0000 4 yes
GO:0007605 sensory perception of sound 25.0000 6 yes
GO:0009063 cellular amino acid catabolic process 25.0000 4 yes
GO:0009066 aspartate family amino acid metabolic process 25.0000 5 yes
GO:0009068 aspartate family amino acid catabolic process 25.0000 6 yes
GO:0009890 negative regulation of biosynthetic process 25.0000 5 yes
GO:0009914 hormone transport 25.0000 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 yes
GO:0016054 organic acid catabolic process 25.0000 4 yes
GO:0018958 phenol-containing compound metabolic process 25.0000 4 yes
GO:0019752 carboxylic acid metabolic process 25.0000 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 yes
GO:0043436 oxoacid metabolic process 25.0000 4 yes
GO:0045892 negative regulation of DNA-templated transcription 25.0000 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 6 yes
GO:0046395 carboxylic acid catabolic process 25.0000 5 yes
GO:0050954 sensory perception of mechanical stimulus 25.0000 5 yes
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 yes
GO:0070327 thyroid hormone transport 25.0000 5 yes
GO:1901565 organonitrogen compound catabolic process 25.0000 4 yes
GO:1901605 alpha-amino acid metabolic process 25.0000 4 yes
GO:1901606 alpha-amino acid catabolic process 25.0000 5 yes
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 25.0000 8 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0007612 learning 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050890 cognition 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:1905475 regulation of protein localization to membrane 25.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 25.0000 5 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0016241 regulation of macroautophagy 25.0000 7 no
GO:0032091 negative regulation of protein binding 25.0000 5 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0045926 negative regulation of growth 25.0000 4 no
GO:0051100 negative regulation of binding 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:1901652 response to peptide 25.0000 4 no
GO:1901653 cellular response to peptide 25.0000 5 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0006811 ion transport 25.0000 4 no
GO:0006812 cation transport 25.0000 5 no

Disease

Term Name % Distance from top the of the tree Annotated in CRYM_HUMAN
DOID:0050155 sensory system disease 25.0000 3 yes
DOID:0050563 nonsyndromic deafness 25.0000 5 yes
DOID:0050564 autosomal dominant nonsyndromic deafness 25.0000 6 yes
DOID:0110566 autosomal dominant nonsyndromic deafness 40 25.0000 7 yes
DOID:2742 auditory system disease 25.0000 4 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CRYM_HUMAN [view entry] [view interactions] Low throughput yes yes
THYG_HUMAN [view interactions] Low throughput no no
CG025_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
RN126_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
LEG7_HUMAN [view interactions] High throughput no no
FCG2B_HUMAN [view interactions] High throughput no no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
SOX_HUMAN [view interactions] Computational no no