Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GNA14_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GNA14_HUMAN
GO:0046872 metal ion binding 58.3333 4 yes
GO:0003924 GTPase activity 50.0000 7 yes
GO:0016462 pyrophosphatase activity 50.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 yes
GO:0017076 purine nucleotide binding 41.6667 4 yes
GO:0032555 purine ribonucleotide binding 41.6667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.6667 4 yes
GO:0001664 G protein-coupled receptor binding 37.5000 4 yes
GO:0005525 GTP binding 37.5000 5 yes
GO:0019001 guanyl nucleotide binding 37.5000 5 yes
GO:0032561 guanyl ribonucleotide binding 37.5000 5 yes
GO:0030159 signaling receptor complex adaptor activity 20.8333 4 no
GO:0019900 kinase binding 20.8333 4 no
GO:0019901 protein kinase binding 20.8333 5 no
GO:0031821 G protein-coupled serotonin receptor binding 20.8333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GNA14_HUMAN
GO:0009966 regulation of signal transduction 54.1667 4 no
GO:0010646 regulation of cell communication 54.1667 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 41.6667 4 yes
GO:0051049 regulation of transport 41.6667 4 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0010959 regulation of metal ion transport 29.1667 6 no
GO:0051240 positive regulation of multicellular organismal process 29.1667 4 no
GO:0051924 regulation of calcium ion transport 29.1667 7 no
GO:0009967 positive regulation of signal transduction 29.1667 5 no
GO:0010647 positive regulation of cell communication 29.1667 5 no
GO:0023056 positive regulation of signaling 29.1667 4 no
GO:0045595 regulation of cell differentiation 29.1667 4 no
GO:0051128 regulation of cellular component organization 29.1667 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0006996 organelle organization 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0008104 protein localization 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 20.8333 4 yes
GO:0014070 response to organic cyclic compound 20.8333 4 no
GO:0032870 cellular response to hormone stimulus 20.8333 4 no
GO:0033993 response to lipid 20.8333 4 no
GO:0071407 cellular response to organic cyclic compound 20.8333 5 no
GO:0071417 cellular response to organonitrogen compound 20.8333 4 no
GO:1901699 cellular response to nitrogen compound 20.8333 4 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0008284 positive regulation of cell population proliferation 20.8333 5 no
GO:0030335 positive regulation of cell migration 20.8333 6 no
GO:0040017 positive regulation of locomotion 20.8333 4 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0043270 positive regulation of ion transport 20.8333 5 no
GO:0051094 positive regulation of developmental process 20.8333 4 no
GO:1903169 regulation of calcium ion transmembrane transport 20.8333 7 no
GO:2000147 positive regulation of cell motility 20.8333 5 no
GO:0009892 negative regulation of metabolic process 20.8333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0031324 negative regulation of cellular metabolic process 20.8333 5 no
GO:0031399 regulation of protein modification process 20.8333 6 no
GO:0043086 negative regulation of catalytic activity 20.8333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.8333 5 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0009968 negative regulation of signal transduction 20.8333 5 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0043066 negative regulation of apoptotic process 20.8333 7 no
GO:0043069 negative regulation of programmed cell death 20.8333 6 no
GO:0043085 positive regulation of catalytic activity 20.8333 4 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 20.8333 4 no
GO:0051336 regulation of hydrolase activity 20.8333 4 no
GO:0095500 acetylcholine receptor signaling pathway 20.8333 4 no
GO:0043408 regulation of MAPK cascade 20.8333 6 no
GO:0043410 positive regulation of MAPK cascade 20.8333 7 no
GO:0001508 action potential 12.5000 4 yes
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway 8.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
JMJD6_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SNW1_HUMAN [view interactions] High throughput no yes
DNAL4_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KAT5_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAT1_HUMAN [view interactions] High throughput no no
GNA15_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GNAO_HUMAN [view entry] [view interactions] Computational yes yes
ARF6_HUMAN [view entry] [view interactions] Computational yes yes
PAR4_HUMAN [view entry] [view interactions] Computational yes no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
MK14_HUMAN [view interactions] Computational no yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
RGSL_HUMAN [view interactions] Computational no no
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
CXCR1_HUMAN [view interactions] Computational no yes
MK08_HUMAN [view interactions] Computational no yes
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
TRPC6_HUMAN [view interactions] Computational no no
GBB2_HUMAN [view entry] [view interactions] Computational yes yes
ARRC_HUMAN [view interactions] Computational no no
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
GBG4_HUMAN [view interactions] Computational no no
IL8_HUMAN [view interactions] Computational no no
S1PR3_HUMAN [view interactions] Computational no no
LPAR3_HUMAN [view interactions] Computational no no
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
GBB3_HUMAN [view interactions] Computational no yes
LPAR2_HUMAN [view interactions] Computational no yes
ESR1_HUMAN [view interactions] Computational no no
GBB4_HUMAN [view entry] [view interactions] Computational yes yes
EDNRA_HUMAN [view interactions] Computational no yes
NHRF1_HUMAN [view interactions] Computational no no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
EDNRB_HUMAN [view interactions] Computational no no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
ESR2_HUMAN [view interactions] Computational no no
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
TA2R_HUMAN [view interactions] Computational no no
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
MTG1_HUMAN [view interactions] Computational no yes
BKRB2_HUMAN [view interactions] Computational no yes
PLCB3_HUMAN [view entry] [view interactions] Computational yes no
PLCB2_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
EDN1_HUMAN [view interactions] Computational no no
CXCR2_HUMAN [view interactions] Computational no no