Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
288 Ile Ser Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -
359 Ile Met Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -
361 Tyr Cys Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -
362 Gly Ser Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -
388 Leu Val Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -
432 Leu Pro Neurodevelopmentaldisorderwithorwithoutvariablemovementorbehavioralabnormalities(NEDMAB) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI004761 DOC_PP2B_PxIxIT_1 DOC 64 69 -
ELMI004761 DOC_PP2B_PxIxIT_1 DOC 64 69 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNN2_HUMAN
GO:0043169 cation binding 71.4286 4 no
GO:0046872 metal ion binding 71.4286 5 no
GO:0005509 calcium ion binding 57.1429 6 no
GO:0031432 titin binding 57.1429 4 no
GO:0010853 cyclase activator activity 42.8571 4 no
GO:0010854 adenylate cyclase regulator activity 42.8571 4 no
GO:0010856 adenylate cyclase activator activity 42.8571 5 no
GO:0019209 kinase activator activity 42.8571 4 no
GO:0019211 phosphatase activator activity 42.8571 4 no
GO:0019887 protein kinase regulator activity 42.8571 4 no
GO:0019888 protein phosphatase regulator activity 42.8571 4 no
GO:0019900 kinase binding 42.8571 4 no
GO:0019901 protein kinase binding 42.8571 5 no
GO:0030295 protein kinase activator activity 42.8571 5 no
GO:0043539 protein serine/threonine kinase activator activity 42.8571 6 no
GO:0072542 protein phosphatase activator activity 42.8571 5 no
GO:0005216 monoatomic ion channel activity 28.5714 4 yes
GO:0005227 calcium-activated cation channel activity 28.5714 7 yes
GO:0005242 inward rectifier potassium channel activity 28.5714 7 yes
GO:0005244 voltage-gated monoatomic ion channel activity 28.5714 5 yes
GO:0005249 voltage-gated potassium channel activity 28.5714 7 yes
GO:0005261 monoatomic cation channel activity 28.5714 5 yes
GO:0005267 potassium channel activity 28.5714 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 28.5714 4 yes
GO:0015079 potassium ion transmembrane transporter activity 28.5714 6 yes
GO:0015267 channel activity 28.5714 4 yes
GO:0015269 calcium-activated potassium channel activity 28.5714 7 yes
GO:0015276 ligand-gated monoatomic ion channel activity 28.5714 5 yes
GO:0016286 small conductance calcium-activated potassium channel activity 28.5714 8 yes
GO:0022832 voltage-gated channel activity 28.5714 6 yes
GO:0022834 ligand-gated channel activity 28.5714 6 yes
GO:0022836 gated channel activity 28.5714 5 yes
GO:0022839 monoatomic ion-gated channel activity 28.5714 7 yes
GO:0022843 voltage-gated monoatomic cation channel activity 28.5714 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 28.5714 4 yes
GO:0042803 protein homodimerization activity 28.5714 4 yes
GO:0042805 actinin binding 28.5714 4 yes
GO:0046873 metal ion transmembrane transporter activity 28.5714 5 yes
GO:0051393 alpha-actinin binding 28.5714 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 28.5714 6 yes
GO:0005246 calcium channel regulator activity 28.5714 5 no
GO:0008200 ion channel inhibitor activity 28.5714 5 no
GO:0016248 channel inhibitor activity 28.5714 4 no
GO:0019855 calcium channel inhibitor activity 28.5714 6 no
GO:0099106 ion channel regulator activity 28.5714 4 no
GO:0008179 adenylate cyclase binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNN2_HUMAN
GO:0010959 regulation of metal ion transport 85.7143 6 yes
GO:0034762 regulation of transmembrane transport 85.7143 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 85.7143 5 yes
GO:0043269 regulation of monoatomic ion transport 85.7143 5 yes
GO:0051049 regulation of transport 85.7143 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 85.7143 6 yes
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:1904063 negative regulation of cation transmembrane transport 57.1429 7 no
GO:1904064 positive regulation of cation transmembrane transport 57.1429 7 no
GO:2001257 regulation of cation channel activity 57.1429 6 no
GO:2001259 positive regulation of cation channel activity 57.1429 6 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0022898 regulation of transmembrane transporter activity 57.1429 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0032410 negative regulation of transporter activity 57.1429 4 no
GO:0032411 positive regulation of transporter activity 57.1429 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 57.1429 5 no
GO:0032413 negative regulation of ion transmembrane transporter activity 57.1429 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 57.1429 5 no
GO:0034763 negative regulation of transmembrane transport 57.1429 5 no
GO:0034764 positive regulation of transmembrane transport 57.1429 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 57.1429 6 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 57.1429 6 no
GO:0043270 positive regulation of monoatomic ion transport 57.1429 5 no
GO:0043271 negative regulation of monoatomic ion transport 57.1429 5 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051050 positive regulation of transport 57.1429 4 no
GO:0051051 negative regulation of transport 57.1429 4 no
GO:0051726 regulation of cell cycle 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0090257 regulation of muscle system process 42.8571 5 no
GO:0141124 intracellular signaling cassette 42.8571 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 42.8571 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 42.8571 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 42.8571 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 42.8571 6 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:1903169 regulation of calcium ion transmembrane transport 42.8571 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 42.8571 7 no
GO:1903522 regulation of blood circulation 42.8571 5 no
GO:1904427 positive regulation of calcium ion transmembrane transport 42.8571 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 42.8571 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 42.8571 8 no
GO:2001258 negative regulation of cation channel activity 42.8571 6 no
GO:0043266 regulation of potassium ion transport 42.8571 7 yes
GO:1901379 regulation of potassium ion transmembrane transport 42.8571 7 yes
GO:0000086 G2/M transition of mitotic cell cycle 42.8571 5 no
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0001933 negative regulation of protein phosphorylation 42.8571 8 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0005513 detection of calcium ion 42.8571 4 no
GO:0006937 regulation of muscle contraction 42.8571 6 no
GO:0006942 regulation of striated muscle contraction 42.8571 7 no
GO:0008016 regulation of heart contraction 42.8571 6 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010038 response to metal ion 42.8571 4 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0010563 negative regulation of phosphorus metabolic process 42.8571 6 no
GO:0010564 regulation of cell cycle process 42.8571 5 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0010649 regulation of cell communication by electrical coupling 42.8571 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 42.8571 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 42.8571 9 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 42.8571 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 42.8571 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 42.8571 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 42.8571 6 no
GO:0010921 regulation of phosphatase activity 42.8571 5 no
GO:0010922 positive regulation of phosphatase activity 42.8571 6 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0019722 calcium-mediated signaling 42.8571 5 no
GO:0021762 substantia nigra development 42.8571 4 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031400 negative regulation of protein modification process 42.8571 7 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0031952 regulation of protein autophosphorylation 42.8571 8 no
GO:0031954 positive regulation of protein autophosphorylation 42.8571 9 no
GO:0032465 regulation of cytokinesis 42.8571 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 42.8571 7 no
GO:0033674 positive regulation of kinase activity 42.8571 6 no
GO:0035303 regulation of dephosphorylation 42.8571 7 no
GO:0035304 regulation of protein dephosphorylation 42.8571 7 no
GO:0035306 positive regulation of dephosphorylation 42.8571 8 no
GO:0035307 positive regulation of protein dephosphorylation 42.8571 8 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0042326 negative regulation of phosphorylation 42.8571 8 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0043085 positive regulation of catalytic activity 42.8571 4 no
GO:0043549 regulation of kinase activity 42.8571 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 42.8571 6 no
GO:0044057 regulation of system process 42.8571 4 no
GO:0044772 mitotic cell cycle phase transition 42.8571 4 no
GO:0044839 cell cycle G2/M phase transition 42.8571 4 no
GO:0045859 regulation of protein kinase activity 42.8571 6 no
GO:0045860 positive regulation of protein kinase activity 42.8571 7 no
GO:0045936 negative regulation of phosphate metabolic process 42.8571 7 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0050848 regulation of calcium-mediated signaling 42.8571 6 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0051248 negative regulation of protein metabolic process 42.8571 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 42.8571 5 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 42.8571 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 42.8571 6 no
GO:0051282 regulation of sequestering of calcium ion 42.8571 4 no
GO:0051284 positive regulation of sequestering of calcium ion 42.8571 5 no
GO:0051302 regulation of cell division 42.8571 4 no
GO:0051336 regulation of hydrolase activity 42.8571 4 no
GO:0051338 regulation of transferase activity 42.8571 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 42.8571 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 42.8571 6 no
GO:0051345 positive regulation of hydrolase activity 42.8571 5 no
GO:0051347 positive regulation of transferase activity 42.8571 5 no
GO:0051592 response to calcium ion 42.8571 5 no
GO:0051924 regulation of calcium ion transport 42.8571 7 no
GO:0051926 negative regulation of calcium ion transport 42.8571 6 no
GO:0051928 positive regulation of calcium ion transport 42.8571 6 no
GO:0055117 regulation of cardiac muscle contraction 42.8571 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 42.8571 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 42.8571 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 42.8571 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 42.8571 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 42.8571 8 no
GO:0098901 regulation of cardiac muscle cell action potential 28.5714 4 no
GO:1901385 regulation of voltage-gated calcium channel activity 28.5714 7 no
GO:1901386 negative regulation of voltage-gated calcium channel activity 28.5714 7 no
GO:1901841 regulation of high voltage-gated calcium channel activity 28.5714 8 no
GO:1901842 negative regulation of high voltage-gated calcium channel activity 28.5714 8 no
GO:0006996 organelle organization 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0006811 monoatomic ion transport 28.5714 4 yes
GO:0006812 monoatomic cation transport 28.5714 5 yes
GO:0006813 potassium ion transport 28.5714 7 yes
GO:0030001 metal ion transport 28.5714 6 yes
GO:0071805 potassium ion transmembrane transport 28.5714 5 yes
GO:0086009 membrane repolarization 28.5714 4 yes
GO:0086011 membrane repolarization during action potential 28.5714 5 yes
GO:0086013 membrane repolarization during cardiac muscle cell action potential 28.5714 6 yes
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 yes
GO:0098662 inorganic cation transmembrane transport 28.5714 4 yes
GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential 28.5714 7 yes
GO:0099622 cardiac muscle cell membrane repolarization 28.5714 5 yes
GO:0099624 atrial cardiac muscle cell membrane repolarization 28.5714 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNN2_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes