KCNN2_HUMAN
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCNN2_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 71.4286 | 4 | no |
GO:0005509 | calcium ion binding | 57.1429 | 5 | no |
GO:0031432 | titin binding | 57.1429 | 4 | no |
GO:0008179 | adenylate cyclase binding | 42.8571 | 4 | no |
GO:0010856 | adenylate cyclase activator activity | 42.8571 | 4 | no |
GO:0019209 | kinase activator activity | 42.8571 | 4 | no |
GO:0019211 | phosphatase activator activity | 42.8571 | 4 | no |
GO:0019887 | protein kinase regulator activity | 42.8571 | 4 | no |
GO:0019888 | protein phosphatase regulator activity | 42.8571 | 4 | no |
GO:0019900 | kinase binding | 42.8571 | 4 | no |
GO:0019901 | protein kinase binding | 42.8571 | 5 | no |
GO:0030295 | protein kinase activator activity | 42.8571 | 5 | no |
GO:0031997 | N-terminal myristoylation domain binding | 42.8571 | 4 | no |
GO:0043539 | protein serine/threonine kinase activator activity | 42.8571 | 6 | no |
GO:0072542 | protein phosphatase activator activity | 42.8571 | 5 | no |
GO:0097718 | disordered domain specific binding | 42.8571 | 4 | no |
GO:0005216 | ion channel activity | 28.5714 | 4 | yes |
GO:0005227 | calcium activated cation channel activity | 28.5714 | 6 | yes |
GO:0005242 | inward rectifier potassium channel activity | 28.5714 | 7 | yes |
GO:0005244 | voltage-gated ion channel activity | 28.5714 | 4 | yes |
GO:0005249 | voltage-gated potassium channel activity | 28.5714 | 6 | yes |
GO:0005261 | cation channel activity | 28.5714 | 5 | yes |
GO:0005267 | potassium channel activity | 28.5714 | 6 | yes |
GO:0008324 | cation transmembrane transporter activity | 28.5714 | 4 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 28.5714 | 6 | yes |
GO:0015267 | channel activity | 28.5714 | 4 | yes |
GO:0015269 | calcium-activated potassium channel activity | 28.5714 | 7 | yes |
GO:0015276 | ligand-gated ion channel activity | 28.5714 | 5 | yes |
GO:0016286 | small conductance calcium-activated potassium channel activity | 28.5714 | 8 | yes |
GO:0022832 | voltage-gated channel activity | 28.5714 | 6 | yes |
GO:0022834 | ligand-gated channel activity | 28.5714 | 6 | yes |
GO:0022836 | gated channel activity | 28.5714 | 5 | yes |
GO:0022839 | ion gated channel activity | 28.5714 | 6 | yes |
GO:0022843 | voltage-gated cation channel activity | 28.5714 | 5 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 28.5714 | 4 | yes |
GO:0042803 | protein homodimerization activity | 28.5714 | 4 | yes |
GO:0042805 | actinin binding | 28.5714 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 28.5714 | 5 | yes |
GO:0051393 | alpha-actinin binding | 28.5714 | 5 | yes |
GO:0099094 | ligand-gated cation channel activity | 28.5714 | 6 | yes |
GO:0005246 | calcium channel regulator activity | 28.5714 | 4 | no |
GO:0008200 | ion channel inhibitor activity | 28.5714 | 4 | no |
GO:0019855 | calcium channel inhibitor activity | 28.5714 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCNN2_HUMAN |
---|---|---|---|---|
GO:0010959 | regulation of metal ion transport | 85.7143 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 85.7143 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 85.7143 | 5 | yes |
GO:0043269 | regulation of ion transport | 85.7143 | 5 | yes |
GO:0051049 | regulation of transport | 85.7143 | 4 | yes |
GO:1904062 | regulation of cation transmembrane transport | 85.7143 | 6 | yes |
GO:0048522 | positive regulation of cellular process | 71.4286 | 4 | no |
GO:0032414 | positive regulation of ion transmembrane transporter activity | 57.1429 | 5 | no |
GO:0034763 | negative regulation of transmembrane transport | 57.1429 | 5 | no |
GO:0034764 | positive regulation of transmembrane transport | 57.1429 | 5 | no |
GO:0034766 | negative regulation of ion transmembrane transport | 57.1429 | 6 | no |
GO:0034767 | positive regulation of ion transmembrane transport | 57.1429 | 6 | no |
GO:0043270 | positive regulation of ion transport | 57.1429 | 5 | no |
GO:0043271 | negative regulation of ion transport | 57.1429 | 5 | no |
GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | no |
GO:0051050 | positive regulation of transport | 57.1429 | 4 | no |
GO:0051051 | negative regulation of transport | 57.1429 | 4 | no |
GO:1904063 | negative regulation of cation transmembrane transport | 57.1429 | 7 | no |
GO:1904064 | positive regulation of cation transmembrane transport | 57.1429 | 7 | no |
GO:2001257 | regulation of cation channel activity | 57.1429 | 6 | no |
GO:2001259 | positive regulation of cation channel activity | 57.1429 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 57.1429 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 57.1429 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 57.1429 | 4 | no |
GO:0051726 | regulation of cell cycle | 57.1429 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 57.1429 | 4 | no |
GO:0022898 | regulation of transmembrane transporter activity | 57.1429 | 4 | no |
GO:0032410 | negative regulation of transporter activity | 57.1429 | 4 | no |
GO:0032411 | positive regulation of transporter activity | 57.1429 | 4 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 57.1429 | 5 | no |
GO:0032413 | negative regulation of ion transmembrane transporter activity | 57.1429 | 5 | no |
GO:0032465 | regulation of cytokinesis | 42.8571 | 5 | no |
GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 42.8571 | 7 | no |
GO:0033674 | positive regulation of kinase activity | 42.8571 | 6 | no |
GO:0035303 | regulation of dephosphorylation | 42.8571 | 7 | no |
GO:0035304 | regulation of protein dephosphorylation | 42.8571 | 7 | no |
GO:0035306 | positive regulation of dephosphorylation | 42.8571 | 8 | no |
GO:0035307 | positive regulation of protein dephosphorylation | 42.8571 | 8 | no |
GO:0042325 | regulation of phosphorylation | 42.8571 | 7 | no |
GO:0042326 | negative regulation of phosphorylation | 42.8571 | 8 | no |
GO:0042327 | positive regulation of phosphorylation | 42.8571 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 42.8571 | 4 | no |
GO:0043388 | positive regulation of DNA binding | 42.8571 | 5 | no |
GO:0043549 | regulation of kinase activity | 42.8571 | 5 | no |
GO:0043666 | regulation of phosphoprotein phosphatase activity | 42.8571 | 6 | no |
GO:0044057 | regulation of system process | 42.8571 | 4 | no |
GO:0044772 | mitotic cell cycle phase transition | 42.8571 | 4 | no |
GO:0044839 | cell cycle G2/M phase transition | 42.8571 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 42.8571 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 42.8571 | 7 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 42.8571 | 7 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 42.8571 | 7 | no |
GO:0050848 | regulation of calcium-mediated signaling | 42.8571 | 6 | no |
GO:0051099 | positive regulation of binding | 42.8571 | 4 | no |
GO:0051101 | regulation of DNA binding | 42.8571 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 42.8571 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.8571 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 42.8571 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 42.8571 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 42.8571 | 6 | no |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 42.8571 | 5 | no |
GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 42.8571 | 6 | no |
GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 42.8571 | 6 | no |
GO:0051282 | regulation of sequestering of calcium ion | 42.8571 | 4 | no |
GO:0051284 | positive regulation of sequestering of calcium ion | 42.8571 | 5 | no |
GO:0051302 | regulation of cell division | 42.8571 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 42.8571 | 4 | no |
GO:0051338 | regulation of transferase activity | 42.8571 | 4 | no |
GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity | 42.8571 | 5 | no |
GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 42.8571 | 6 | no |
GO:0051345 | positive regulation of hydrolase activity | 42.8571 | 5 | no |
GO:0051347 | positive regulation of transferase activity | 42.8571 | 5 | no |
GO:0051592 | response to calcium ion | 42.8571 | 5 | no |
GO:0051924 | regulation of calcium ion transport | 42.8571 | 7 | no |
GO:0051926 | negative regulation of calcium ion transport | 42.8571 | 6 | no |
GO:0051928 | positive regulation of calcium ion transport | 42.8571 | 6 | no |
GO:0055117 | regulation of cardiac muscle contraction | 42.8571 | 7 | no |
GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 42.8571 | 6 | no |
GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 42.8571 | 7 | no |
GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 42.8571 | 7 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 42.8571 | 7 | no |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 42.8571 | 8 | no |
GO:0090257 | regulation of muscle system process | 42.8571 | 5 | no |
GO:1901019 | regulation of calcium ion transmembrane transporter activity | 42.8571 | 6 | no |
GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 42.8571 | 6 | no |
GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 42.8571 | 6 | no |
GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 42.8571 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 42.8571 | 5 | no |
GO:1903169 | regulation of calcium ion transmembrane transport | 42.8571 | 7 | no |
GO:1903170 | negative regulation of calcium ion transmembrane transport | 42.8571 | 7 | no |
GO:1903522 | regulation of blood circulation | 42.8571 | 5 | no |
GO:1904427 | positive regulation of calcium ion transmembrane transport | 42.8571 | 7 | no |
GO:1905912 | regulation of calcium ion export across plasma membrane | 42.8571 | 8 | no |
GO:1905913 | negative regulation of calcium ion export across plasma membrane | 42.8571 | 8 | no |
GO:2001258 | negative regulation of cation channel activity | 42.8571 | 6 | no |
GO:0006811 | ion transport | 42.8571 | 4 | yes |
GO:0006812 | cation transport | 42.8571 | 5 | yes |
GO:0006813 | potassium ion transport | 42.8571 | 7 | yes |
GO:0030001 | metal ion transport | 42.8571 | 6 | yes |
GO:0043266 | regulation of potassium ion transport | 42.8571 | 7 | yes |
GO:0071805 | potassium ion transmembrane transport | 42.8571 | 6 | yes |
GO:0098655 | cation transmembrane transport | 42.8571 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 42.8571 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 42.8571 | 5 | yes |
GO:1901379 | regulation of potassium ion transmembrane transport | 42.8571 | 7 | yes |
GO:0006996 | organelle organization | 42.8571 | 4 | no |
GO:0010941 | regulation of cell death | 42.8571 | 4 | no |
GO:0042981 | regulation of apoptotic process | 42.8571 | 6 | no |
GO:0043067 | regulation of programmed cell death | 42.8571 | 5 | no |
GO:0000086 | G2/M transition of mitotic cell cycle | 42.8571 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 42.8571 | 7 | no |
GO:0001933 | negative regulation of protein phosphorylation | 42.8571 | 8 | no |
GO:0001934 | positive regulation of protein phosphorylation | 42.8571 | 8 | no |
GO:0005513 | detection of calcium ion | 42.8571 | 4 | no |
GO:0006937 | regulation of muscle contraction | 42.8571 | 6 | no |
GO:0006942 | regulation of striated muscle contraction | 42.8571 | 7 | no |
GO:0008016 | regulation of heart contraction | 42.8571 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
GO:0010038 | response to metal ion | 42.8571 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 42.8571 | 6 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 42.8571 | 6 | no |
GO:0010564 | regulation of cell cycle process | 42.8571 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 42.8571 | 5 | no |
GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
GO:0010649 | regulation of cell communication by electrical coupling | 42.8571 | 5 | no |
GO:0010799 | regulation of peptidyl-threonine phosphorylation | 42.8571 | 8 | no |
GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 42.8571 | 9 | no |
GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 42.8571 | 9 | no |
GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 42.8571 | 6 | no |
GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 42.8571 | 7 | no |
GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 42.8571 | 6 | no |
GO:0010921 | regulation of phosphatase activity | 42.8571 | 5 | no |
GO:0010922 | positive regulation of phosphatase activity | 42.8571 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 42.8571 | 6 | no |
GO:0019722 | calcium-mediated signaling | 42.8571 | 5 | no |
GO:0019932 | second-messenger-mediated signaling | 42.8571 | 4 | no |
GO:0021762 | substantia nigra development | 42.8571 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0031399 | regulation of protein modification process | 42.8571 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 42.8571 | 7 | no |
GO:0031401 | positive regulation of protein modification process | 42.8571 | 7 | no |
GO:0031952 | regulation of protein autophosphorylation | 42.8571 | 8 | no |
GO:0031954 | positive regulation of protein autophosphorylation | 42.8571 | 9 | no |
GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | no |
GO:0072657 | protein localization to membrane | 28.5714 | 4 | no |
GO:0098901 | regulation of cardiac muscle cell action potential | 28.5714 | 4 | no |
GO:1901385 | regulation of voltage-gated calcium channel activity | 28.5714 | 7 | no |
GO:1901386 | negative regulation of voltage-gated calcium channel activity | 28.5714 | 7 | no |
GO:1901841 | regulation of high voltage-gated calcium channel activity | 28.5714 | 8 | no |
GO:1901842 | negative regulation of high voltage-gated calcium channel activity | 28.5714 | 8 | no |
GO:0086009 | membrane repolarization | 28.5714 | 4 | yes |
GO:0086011 | membrane repolarization during action potential | 28.5714 | 5 | yes |
GO:0086013 | membrane repolarization during cardiac muscle cell action potential | 28.5714 | 6 | yes |
GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential | 28.5714 | 7 | yes |
GO:0099622 | cardiac muscle cell membrane repolarization | 28.5714 | 5 | yes |
GO:0099624 | atrial cardiac muscle cell membrane repolarization | 28.5714 | 6 | yes |
GO:0006468 | protein phosphorylation | 28.5714 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | no |
GO:0010942 | positive regulation of cell death | 28.5714 | 5 | no |
GO:0016310 | phosphorylation | 28.5714 | 5 | no |
GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
GO:0036211 | protein modification process | 28.5714 | 4 | no |
GO:0043065 | positive regulation of apoptotic process | 28.5714 | 7 | no |
GO:0043068 | positive regulation of programmed cell death | 28.5714 | 6 | no |
GO:0043412 | macromolecule modification | 28.5714 | 4 | no |
GO:0008104 | protein localization | 28.5714 | 4 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCNN2_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 42.8571 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 42.8571 | 5 | no |
DOID:114 | heart disease | 42.8571 | 3 | no |
DOID:2843 | long QT syndrome | 28.5714 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |