Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RIMB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RIMB2_HUMAN
GO:0046872 metal ion binding 44.4444 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0031267 small GTPase binding 22.2222 5 no
GO:0051020 GTPase binding 22.2222 4 no
GO:0017076 purine nucleotide binding 22.2222 4 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RIMB2_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0009966 regulation of signal transduction 66.6667 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0048584 positive regulation of response to stimulus 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0009967 positive regulation of signal transduction 55.5556 5 no
GO:0010647 positive regulation of cell communication 55.5556 5 no
GO:0023056 positive regulation of signaling 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0006796 phosphate-containing compound metabolic process 44.4444 4 no
GO:0036211 protein modification process 44.4444 4 no
GO:0043412 macromolecule modification 44.4444 4 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 5 no
GO:0016192 vesicle-mediated transport 44.4444 4 no
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 no
GO:0046903 secretion 44.4444 4 no
GO:0051046 regulation of secretion 44.4444 5 no
GO:0051049 regulation of transport 44.4444 4 no
GO:1903530 regulation of secretion by cell 44.4444 4 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0001558 regulation of cell growth 33.3333 4 no
GO:0006887 exocytosis 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0015031 protein transport 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030307 positive regulation of cell growth 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045927 positive regulation of growth 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0022411 cellular component disassembly 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006469 negative regulation of protein kinase activity 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0033673 negative regulation of kinase activity 22.2222 6 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0032872 regulation of stress-activated MAPK cascade 22.2222 6 no
GO:0032874 positive regulation of stress-activated MAPK cascade 22.2222 7 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0046328 regulation of JNK cascade 22.2222 7 no
GO:0046330 positive regulation of JNK cascade 22.2222 8 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 22.2222 5 no
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 22.2222 6 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0072659 protein localization to plasma membrane 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1990778 protein localization to cell periphery 22.2222 5 no
GO:0009306 protein secretion 22.2222 4 no
GO:0017157 regulation of exocytosis 22.2222 5 no
GO:0035592 establishment of protein localization to extracellular region 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0071692 protein localization to extracellular region 22.2222 5 no
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:0006886 intracellular protein transport 22.2222 4 no
GO:0016079 synaptic vesicle exocytosis 22.2222 4 no
GO:0017156 calcium-ion regulated exocytosis 22.2222 6 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0023061 signal release 22.2222 4 no
GO:0031644 regulation of nervous system process 22.2222 5 no
GO:0031646 positive regulation of nervous system process 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0045055 regulated exocytosis 22.2222 5 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0048639 positive regulation of developmental growth 22.2222 5 no
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0097151 positive regulation of inhibitory postsynaptic potential 22.2222 5 no
GO:0098815 modulation of excitatory postsynaptic potential 22.2222 4 no
GO:0098828 modulation of inhibitory postsynaptic potential 22.2222 4 no
GO:0099003 vesicle-mediated transport in synapse 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0099643 signal release from synapse 22.2222 5 no
GO:1903859 regulation of dendrite extension 22.2222 5 no
GO:1903861 positive regulation of dendrite extension 22.2222 6 no
GO:2000463 positive regulation of excitatory postsynaptic potential 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAC1A_HUMAN [view interactions] Low throughput no no
CAC1B_HUMAN [view interactions] Low throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
ADA12_HUMAN [view interactions] High throughput no no
UBP3_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
NAA10_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
RAB3C_HUMAN [view entry] [view interactions] Computational yes yes
RIMS1_HUMAN [view entry] [view interactions] Computational yes yes
RIMS2_HUMAN [view entry] [view interactions] Computational yes no
CAC1D_HUMAN [view interactions] Computational no yes
JIP1_HUMAN [view entry] [view interactions] Computational yes yes