Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EDAD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EDAD_HUMAN
GO:0016755 aminoacyltransferase activity 50.0000 4 no
GO:0061659 ubiquitin-like protein ligase activity 37.5000 4 no
GO:0031625 ubiquitin protein ligase binding 37.5000 5 no
GO:0044389 ubiquitin-like protein ligase binding 37.5000 4 no
GO:0005126 cytokine receptor binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0004842 ubiquitin-protein transferase activity 25.0000 4 no
GO:0061630 ubiquitin protein ligase activity 25.0000 5 no
GO:0003723 RNA binding 25.0000 4 no
GO:0044388 small protein activating enzyme binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in EDAD_HUMAN
GO:0009889 regulation of biosynthetic process 75.0000 4 no
GO:0009890 negative regulation of biosynthetic process 75.0000 5 no
GO:0009892 negative regulation of metabolic process 75.0000 4 no
GO:0010468 regulation of gene expression 75.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 75.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 75.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 75.0000 5 no
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 75.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 75.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 75.0000 6 no
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 no
GO:0080090 regulation of primary metabolic process 75.0000 4 no
GO:0022607 cellular component assembly 62.5000 4 no
GO:0032446 protein modification by small protein conjugation 62.5000 7 no
GO:0036211 protein modification process 62.5000 4 no
GO:0043412 macromolecule modification 62.5000 4 no
GO:0043687 post-translational protein modification 62.5000 5 no
GO:0051246 regulation of protein metabolic process 62.5000 5 no
GO:0070647 protein modification by small protein conjugation or removal 62.5000 6 no
GO:0006355 regulation of DNA-templated transcription 62.5000 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 62.5000 5 no
GO:0045892 negative regulation of DNA-templated transcription 62.5000 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 62.5000 5 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051252 regulation of RNA metabolic process 62.5000 5 no
GO:0051253 negative regulation of RNA metabolic process 62.5000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 62.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 62.5000 6 no
GO:0006996 organelle organization 50.0000 4 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:1901873 regulation of post-translational protein modification 50.0000 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 50.0000 8 no
GO:0000122 negative regulation of transcription by RNA polymerase II 50.0000 9 no
GO:0006357 regulation of transcription by RNA polymerase II 50.0000 8 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0001817 regulation of cytokine production 37.5000 4 no
GO:0009057 macromolecule catabolic process 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0016567 protein ubiquitination 37.5000 8 no
GO:0031396 regulation of protein ubiquitination 37.5000 9 no
GO:0032479 regulation of type I interferon production 37.5000 5 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051051 negative regulation of transport 37.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0006508 proteolysis 37.5000 4 no
GO:0008284 positive regulation of cell population proliferation 37.5000 5 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0000045 autophagosome assembly 25.0000 6 no
GO:0001818 negative regulation of cytokine production 25.0000 5 no
GO:0002697 regulation of immune effector process 25.0000 4 no
GO:0002700 regulation of production of molecular mediator of immune response 25.0000 5 no
GO:0002718 regulation of cytokine production involved in immune response 25.0000 5 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0007033 vacuole organization 25.0000 5 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0030163 protein catabolic process 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032480 negative regulation of type I interferon production 25.0000 6 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0045806 negative regulation of endocytosis 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051047 positive regulation of secretion 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:1901565 organonitrogen compound catabolic process 25.0000 4 no
GO:1902115 regulation of organelle assembly 25.0000 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 25.0000 6 no
GO:1905037 autophagosome organization 25.0000 6 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 no
GO:0008104 protein localization 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043410 positive regulation of MAPK cascade 25.0000 7 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0000209 protein polyubiquitination 25.0000 9 no
GO:0006974 DNA damage response 25.0000 4 no
GO:0031398 positive regulation of protein ubiquitination 25.0000 10 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0051101 regulation of DNA binding 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0051865 protein autoubiquitination 25.0000 9 no
GO:1901875 positive regulation of post-translational protein modification 25.0000 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:0016925 protein sumoylation 25.0000 7 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0018205 peptidyl-lysine modification 25.0000 6 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EDAR_HUMAN [view interactions] Low throughput no yes
TRAF2_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
TAB2_HUMAN [view interactions] Low throughput no yes
M3K7_HUMAN [view interactions] Low throughput no yes
UVRAG_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
SUMO5_HUMAN [view interactions] High throughput no no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
SHPRH_HUMAN [view interactions] High throughput no yes
RN111_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
EDAD_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes