Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HPLN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HPLN1_HUMAN
GO:0046872 metal ion binding 50.0000 4 no
GO:0005540 hyaluronic acid binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0003779 actin binding 25.0000 4 no
GO:0003677 DNA binding 25.0000 4 no
GO:0003690 double-stranded DNA binding 25.0000 5 no
GO:0008017 microtubule binding 25.0000 5 no
GO:0015631 tubulin binding 25.0000 4 no
GO:0043565 sequence-specific DNA binding 25.0000 5 no
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0004866 endopeptidase inhibitor activity 25.0000 5 no
GO:0030414 peptidase inhibitor activity 25.0000 4 no
GO:0046875 ephrin receptor binding 25.0000 4 no
GO:0046914 transition metal ion binding 25.0000 5 no
GO:0061135 endopeptidase regulator activity 25.0000 4 no
GO:0005509 calcium ion binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in HPLN1_HUMAN
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0032880 regulation of protein localization 50.0000 5 no
GO:0033674 positive regulation of kinase activity 50.0000 6 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0042327 positive regulation of phosphorylation 50.0000 8 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0043549 regulation of kinase activity 50.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051338 regulation of transferase activity 50.0000 4 no
GO:0051347 positive regulation of transferase activity 50.0000 5 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0070201 regulation of establishment of protein localization 50.0000 6 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 no
GO:0007613 memory 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0050890 cognition 50.0000 4 no
GO:0071310 cellular response to organic substance 50.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0010563 negative regulation of phosphorus metabolic process 37.5000 6 no
GO:0031400 negative regulation of protein modification process 37.5000 7 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0042326 negative regulation of phosphorylation 37.5000 8 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0045860 positive regulation of protein kinase activity 37.5000 7 no
GO:0045936 negative regulation of phosphate metabolic process 37.5000 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 37.5000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 37.5000 9 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0051223 regulation of protein transport 37.5000 5 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0061097 regulation of protein tyrosine kinase activity 37.5000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 37.5000 8 no
GO:0099175 regulation of postsynapse organization 37.5000 6 no
GO:1903828 negative regulation of protein localization 37.5000 5 no
GO:0008285 negative regulation of cell population proliferation 37.5000 5 no
GO:0010243 response to organonitrogen compound 37.5000 4 no
GO:0010648 negative regulation of cell communication 37.5000 5 no
GO:0023057 negative regulation of signaling 37.5000 4 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:0048638 regulation of developmental growth 37.5000 4 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0051093 negative regulation of developmental process 37.5000 4 no
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 no
GO:0071417 cellular response to organonitrogen compound 37.5000 4 no
GO:1901699 cellular response to nitrogen compound 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010038 response to metal ion 37.5000 4 no
GO:0010629 negative regulation of gene expression 37.5000 6 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0010942 positive regulation of cell death 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0030162 regulation of proteolysis 37.5000 6 no
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0051259 protein complex oligomerization 37.5000 6 no
GO:0051260 protein homooligomerization 37.5000 7 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:1901214 regulation of neuron death 37.5000 5 no
GO:1901216 positive regulation of neuron death 37.5000 6 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1903829 positive regulation of protein localization 37.5000 5 no
GO:0043525 positive regulation of neuron apoptotic process 25.0000 7 no
GO:0046688 response to copper ion 25.0000 5 no
GO:0046916 cellular transition metal ion homeostasis 25.0000 7 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0048878 chemical homeostasis 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050801 ion homeostasis 25.0000 5 no
GO:0050865 regulation of cell activation 25.0000 4 no
GO:0051222 positive regulation of protein transport 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0055065 metal ion homeostasis 25.0000 7 no
GO:0055070 copper ion homeostasis 25.0000 9 no
GO:0055076 transition metal ion homeostasis 25.0000 8 no
GO:0055080 cation homeostasis 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0071280 cellular response to copper ion 25.0000 6 no
GO:0098771 inorganic ion homeostasis 25.0000 6 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:1900271 regulation of long-term synaptic potentiation 25.0000 4 no
GO:1900272 negative regulation of long-term synaptic potentiation 25.0000 4 no
GO:1901652 response to peptide 25.0000 4 no
GO:1901653 cellular response to peptide 25.0000 5 no
GO:1902950 regulation of dendritic spine maintenance 25.0000 7 no
GO:1902951 negative regulation of dendritic spine maintenance 25.0000 7 no
GO:1902991 regulation of amyloid precursor protein catabolic process 25.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:1904645 response to amyloid-beta 25.0000 5 no
GO:1904646 cellular response to amyloid-beta 25.0000 6 no
GO:1904951 positive regulation of establishment of protein localization 25.0000 6 no
GO:1990535 neuron projection maintenance 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0001501 skeletal system development 25.0000 4 yes
GO:0007417 central nervous system development 25.0000 4 yes
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:1904950 negative regulation of establishment of protein localization 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0014074 response to purine-containing compound 25.0000 5 no
GO:0045596 negative regulation of cell differentiation 25.0000 5 no
GO:0045664 regulation of neuron differentiation 25.0000 5 no
GO:0045665 negative regulation of neuron differentiation 25.0000 6 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0046683 response to organophosphorus 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0001774 microglial cell activation 25.0000 4 no
GO:0007416 synapse assembly 25.0000 6 no
GO:0008088 axo-dendritic transport 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010288 response to lead ion 25.0000 5 no
GO:0010639 negative regulation of organelle organization 25.0000 6 no
GO:0010821 regulation of mitochondrion organization 25.0000 6 no
GO:0010823 negative regulation of mitochondrion organization 25.0000 7 no
GO:0010950 positive regulation of endopeptidase activity 25.0000 7 no
GO:0010952 positive regulation of peptidase activity 25.0000 6 no
GO:0010970 transport along microtubule 25.0000 4 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0030705 cytoskeleton-dependent intracellular transport 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0032928 regulation of superoxide anion generation 25.0000 7 no
GO:0032930 positive regulation of superoxide anion generation 25.0000 7 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042116 macrophage activation 25.0000 4 no
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 25.0000 9 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 25.0000 8 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0048143 astrocyte activation 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no
GO:0050848 regulation of calcium-mediated signaling 25.0000 6 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0052547 regulation of peptidase activity 25.0000 5 no
GO:0052548 regulation of endopeptidase activity 25.0000 6 no
GO:0070848 response to growth factor 25.0000 4 no
GO:0071363 cellular response to growth factor stimulus 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0090322 regulation of superoxide metabolic process 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0099111 microtubule-based transport 25.0000 4 no
GO:1900452 regulation of long-term synaptic depression 25.0000 4 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:1990000 amyloid fibril formation 25.0000 4 no
GO:1990090 cellular response to nerve growth factor stimulus 25.0000 4 no
GO:2000116 regulation of cysteine-type endopeptidase activity 25.0000 7 no
GO:2000377 regulation of reactive oxygen species metabolic process 25.0000 5 no
GO:2000379 positive regulation of reactive oxygen species metabolic process 25.0000 6 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 25.0000 8 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006873 cellular ion homeostasis 25.0000 4 no
GO:0006875 cellular metal ion homeostasis 25.0000 6 no
GO:0006878 cellular copper ion homeostasis 25.0000 8 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0019722 calcium-mediated signaling 25.0000 5 no
GO:0019932 second-messenger-mediated signaling 25.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0030003 cellular cation homeostasis 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031345 negative regulation of cell projection organization 25.0000 6 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0032649 regulation of interferon-gamma production 25.0000 5 no
GO:0034248 regulation of cellular amide metabolic process 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043065 positive regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043068 positive regulation of programmed cell death 25.0000 6 no
GO:0043523 regulation of neuron apoptotic process 25.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSPG2_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SOST_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PGCA_HUMAN [view interactions] High throughput no no
OX1R_HUMAN [view interactions] Computational no yes