Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HPLN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HPLN1_HUMAN
GO:0043169 cation binding 50.0000 4 no
GO:0046872 metal ion binding 50.0000 5 no
GO:0005540 hyaluronic acid binding 25.0000 4 yes
GO:0004866 endopeptidase inhibitor activity 25.0000 5 no
GO:0008017 microtubule binding 25.0000 5 no
GO:0015631 tubulin binding 25.0000 4 no
GO:0030414 peptidase inhibitor activity 25.0000 4 no
GO:0046914 transition metal ion binding 25.0000 6 no
GO:0061135 endopeptidase regulator activity 25.0000 4 no
GO:0003677 DNA binding 25.0000 4 no
GO:0003690 double-stranded DNA binding 25.0000 5 no
GO:0043565 sequence-specific DNA binding 25.0000 5 no
GO:0003779 actin binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in HPLN1_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0042127 regulation of cell population proliferation 62.5000 4 yes
GO:0045595 regulation of cell differentiation 62.5000 4 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0042327 positive regulation of phosphorylation 50.0000 8 no
GO:0043549 regulation of kinase activity 50.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0050890 cognition 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051338 regulation of transferase activity 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 37.5000 6 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0031400 negative regulation of protein modification process 37.5000 7 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0042326 negative regulation of phosphorylation 37.5000 8 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0045936 negative regulation of phosphate metabolic process 37.5000 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 37.5000 8 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0050848 regulation of calcium-mediated signaling 37.5000 6 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0051347 positive regulation of transferase activity 37.5000 5 no
GO:0051726 regulation of cell cycle 37.5000 4 no
GO:0061097 regulation of protein tyrosine kinase activity 37.5000 7 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0071417 cellular response to organonitrogen compound 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:1901699 cellular response to nitrogen compound 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0048638 regulation of developmental growth 37.5000 4 no
GO:0051093 negative regulation of developmental process 37.5000 4 no
GO:0007417 central nervous system development 37.5000 4 yes
GO:0010720 positive regulation of cell development 37.5000 6 yes
GO:0045597 positive regulation of cell differentiation 37.5000 5 yes
GO:0050767 regulation of neurogenesis 37.5000 6 yes
GO:0050769 positive regulation of neurogenesis 37.5000 6 yes
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0051960 regulation of nervous system development 37.5000 5 yes
GO:0051962 positive regulation of nervous system development 37.5000 5 yes
GO:0060284 regulation of cell development 37.5000 5 yes
GO:2000026 regulation of multicellular organismal development 37.5000 4 yes
GO:2000177 regulation of neural precursor cell proliferation 37.5000 5 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0007613 memory 37.5000 4 no
GO:0008285 negative regulation of cell population proliferation 37.5000 5 no
GO:0009890 negative regulation of biosynthetic process 37.5000 5 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010243 response to organonitrogen compound 37.5000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 37.5000 6 no
GO:0010629 negative regulation of gene expression 37.5000 7 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051259 protein complex oligomerization 25.0000 6 no
GO:0051260 protein homooligomerization 25.0000 7 no
GO:0055070 copper ion homeostasis 25.0000 4 no
GO:0055080 monoatomic cation homeostasis 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:1900271 regulation of long-term synaptic potentiation 25.0000 4 no
GO:1900272 negative regulation of long-term synaptic potentiation 25.0000 4 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1904645 response to amyloid-beta 25.0000 4 no
GO:1904646 cellular response to amyloid-beta 25.0000 5 no
GO:1990535 neuron projection maintenance 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0001774 microglial cell activation 25.0000 4 no
GO:0007416 synapse assembly 25.0000 6 no
GO:0008088 axo-dendritic transport 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0010970 transport along microtubule 25.0000 4 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030705 cytoskeleton-dependent intracellular transport 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042116 macrophage activation 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045596 negative regulation of cell differentiation 25.0000 5 no
GO:0045664 regulation of neuron differentiation 25.0000 5 no
GO:0045665 negative regulation of neuron differentiation 25.0000 6 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0048143 astrocyte activation 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0098657 import into cell 25.0000 4 no
GO:0099111 microtubule-based transport 25.0000 4 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:1990000 amyloid fibril formation 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:0001501 skeletal system development 25.0000 4 yes
GO:0002052 positive regulation of neuroblast proliferation 25.0000 7 yes
GO:0008284 positive regulation of cell population proliferation 25.0000 5 yes
GO:0010001 glial cell differentiation 25.0000 4 yes
GO:1902692 regulation of neuroblast proliferation 25.0000 6 yes
GO:2000179 positive regulation of neural precursor cell proliferation 25.0000 6 yes
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0006873 intracellular monoatomic ion homeostasis 25.0000 4 no
GO:0006878 intracellular copper ion homeostasis 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030003 intracellular monoatomic cation homeostasis 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSPG2_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SOST_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PGCA_HUMAN [view interactions] High throughput no no