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MMP9_HUMAN

GO
G2C
SynaptomeDB

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed, PubMed, PubMed). Could play a role in bone osteoclastic resorption . Cleaves KiSS1 at a Gly-|-Leu bond (PubMed). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed). Degrades fibronectin but not laminin or Pz-peptide. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MMP9_HUMAN
GO:0043169 cation binding 83.3333 4 yes
GO:0046872 metal ion binding 83.3333 5 yes
GO:0005509 calcium ion binding 50.0000 6 no
GO:0004175 endopeptidase activity 33.3333 4 yes
GO:0004222 metalloendopeptidase activity 33.3333 5 yes
GO:0004252 serine-type endopeptidase activity 33.3333 5 yes
GO:0008236 serine-type peptidase activity 33.3333 4 yes
GO:0008237 metallopeptidase activity 33.3333 4 yes
GO:0008270 zinc ion binding 33.3333 7 yes
GO:0046914 transition metal ion binding 33.3333 6 yes
GO:0001618 virus receptor activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in MMP9_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0042127 regulation of cell population proliferation 83.3333 4 yes
GO:0042981 regulation of apoptotic process 83.3333 5 yes
GO:0043066 negative regulation of apoptotic process 83.3333 6 yes
GO:0043067 regulation of programmed cell death 83.3333 4 yes
GO:0043069 negative regulation of programmed cell death 83.3333 5 yes
GO:0048523 negative regulation of cellular process 83.3333 4 yes
GO:0048584 positive regulation of response to stimulus 83.3333 4 yes
GO:2000026 regulation of multicellular organismal development 83.3333 4 yes
GO:0009966 regulation of signal transduction 83.3333 4 yes
GO:0009967 positive regulation of signal transduction 83.3333 5 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0010647 positive regulation of cell communication 83.3333 5 yes
GO:0023056 positive regulation of signaling 83.3333 4 yes
GO:0030334 regulation of cell migration 66.6667 5 yes
GO:0030335 positive regulation of cell migration 66.6667 6 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:0040017 positive regulation of locomotion 66.6667 4 yes
GO:0043065 positive regulation of apoptotic process 66.6667 6 yes
GO:0043068 positive regulation of programmed cell death 66.6667 5 yes
GO:0045595 regulation of cell differentiation 66.6667 4 yes
GO:0048585 negative regulation of response to stimulus 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 66.6667 6 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0080134 regulation of response to stress 66.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 yes
GO:1902532 negative regulation of intracellular signal transduction 66.6667 6 yes
GO:2000145 regulation of cell motility 66.6667 4 yes
GO:2000147 positive regulation of cell motility 66.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 66.6667 4 no
GO:0008284 positive regulation of cell population proliferation 66.6667 5 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0009968 negative regulation of signal transduction 66.6667 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0010648 negative regulation of cell communication 66.6667 5 yes
GO:0023057 negative regulation of signaling 66.6667 4 yes
GO:0030162 regulation of proteolysis 50.0000 6 yes
GO:0030198 extracellular matrix organization 50.0000 5 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0031401 positive regulation of protein modification process 50.0000 7 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 50.0000 5 yes
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 50.0000 5 yes
GO:0035987 endodermal cell differentiation 50.0000 4 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0043062 extracellular structure organization 50.0000 4 yes
GO:0043269 regulation of monoatomic ion transport 50.0000 5 yes
GO:0045229 external encapsulating structure organization 50.0000 4 yes
GO:0045596 negative regulation of cell differentiation 50.0000 5 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:0051093 negative regulation of developmental process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 50.0000 6 yes
GO:0051336 regulation of hydrolase activity 50.0000 4 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 50.0000 7 yes
GO:1903131 mononuclear cell differentiation 50.0000 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 50.0000 6 yes
GO:2001233 regulation of apoptotic signaling pathway 50.0000 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 50.0000 6 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 50.0000 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 50.0000 7 yes
GO:2001257 regulation of cation channel activity 50.0000 6 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0001501 skeletal system development 50.0000 4 yes
GO:0001932 regulation of protein phosphorylation 50.0000 7 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0002521 leukocyte differentiation 50.0000 4 yes
GO:0009416 response to light stimulus 50.0000 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010821 regulation of mitochondrion organization 50.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0022898 regulation of transmembrane transporter activity 50.0000 4 yes
GO:0030099 myeloid cell differentiation 33.3333 4 yes
GO:0030225 macrophage differentiation 33.3333 6 yes
GO:0030856 regulation of epithelial cell differentiation 33.3333 5 yes
GO:0030857 negative regulation of epithelial cell differentiation 33.3333 6 yes
GO:0031347 regulation of defense response 33.3333 5 yes
GO:0032092 positive regulation of protein binding 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0032410 negative regulation of transporter activity 33.3333 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 33.3333 5 yes
GO:0032496 response to lipopolysaccharide 33.3333 4 yes
GO:0033993 response to lipid 33.3333 4 yes
GO:0034599 cellular response to oxidative stress 33.3333 4 yes
GO:0034614 cellular response to reactive oxygen species 33.3333 5 yes
GO:0034644 cellular response to UV 33.3333 6 yes
GO:0034763 negative regulation of transmembrane transport 33.3333 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 33.3333 6 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 33.3333 6 yes
GO:0043086 negative regulation of catalytic activity 33.3333 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 7 yes
GO:0043271 negative regulation of monoatomic ion transport 33.3333 5 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 8 yes
GO:0043388 positive regulation of DNA binding 33.3333 5 yes
GO:0043393 regulation of protein binding 33.3333 4 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 33.3333 7 yes
GO:0045861 negative regulation of proteolysis 33.3333 7 yes
GO:0046686 response to cadmium ion 33.3333 5 yes
GO:0048013 ephrin receptor signaling pathway 33.3333 6 yes
GO:0048660 regulation of smooth muscle cell proliferation 33.3333 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 33.3333 6 yes
GO:0050727 regulation of inflammatory response 33.3333 5 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051099 positive regulation of binding 33.3333 4 yes
GO:0051101 regulation of DNA binding 33.3333 4 yes
GO:0051346 negative regulation of hydrolase activity 33.3333 5 yes
GO:0051547 regulation of keratinocyte migration 33.3333 5 yes
GO:0051549 positive regulation of keratinocyte migration 33.3333 6 yes
GO:0052547 regulation of peptidase activity 33.3333 5 yes
GO:0052548 regulation of endopeptidase activity 33.3333 6 yes
GO:0062197 cellular response to chemical stress 33.3333 4 yes
GO:0070141 response to UV-A 33.3333 6 yes
GO:0071219 cellular response to molecule of bacterial origin 33.3333 4 yes
GO:0071222 cellular response to lipopolysaccharide 33.3333 5 yes
GO:0071241 cellular response to inorganic substance 33.3333 4 yes
GO:0071248 cellular response to metal ion 33.3333 5 yes
GO:0071276 cellular response to cadmium ion 33.3333 6 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0071396 cellular response to lipid 33.3333 5 yes
GO:0071478 cellular response to radiation 33.3333 4 yes
GO:0071482 cellular response to light stimulus 33.3333 5 yes
GO:0071492 cellular response to UV-A 33.3333 7 yes
GO:0090200 positive regulation of release of cytochrome c from mitochondria 33.3333 7 yes
GO:0150077 regulation of neuroinflammatory response 33.3333 6 yes
GO:1900120 regulation of receptor binding 33.3333 5 yes
GO:1900122 positive regulation of receptor binding 33.3333 6 yes
GO:1901184 regulation of ERBB signaling pathway 33.3333 5 yes
GO:1901186 positive regulation of ERBB signaling pathway 33.3333 6 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 yes
GO:1904063 negative regulation of cation transmembrane transport 33.3333 7 yes
GO:1904645 response to amyloid-beta 33.3333 4 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 33.3333 6 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 33.3333 7 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 33.3333 8 yes
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 33.3333 6 yes
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development 33.3333 7 yes
GO:2001258 negative regulation of cation channel activity 33.3333 6 yes
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 33.3333 9 yes
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 33.3333 7 yes
GO:0007159 leukocyte cell-cell adhesion 33.3333 4 no
GO:0007160 cell-matrix adhesion 33.3333 4 no
GO:0007229 integrin-mediated signaling pathway 33.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0023035 CD40 signaling pathway 33.3333 4 no
GO:0033631 cell-cell adhesion mediated by integrin 33.3333 4 no
GO:0034113 heterotypic cell-cell adhesion 33.3333 4 no
GO:0035313 wound healing, spreading of epidermal cells 33.3333 5 no
GO:0044319 wound healing, spreading of cells 33.3333 4 no
GO:0045765 regulation of angiogenesis 33.3333 5 no
GO:0045766 positive regulation of angiogenesis 33.3333 6 no
GO:0050890 cognition 33.3333 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 33.3333 4 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 no
GO:1901342 regulation of vasculature development 33.3333 5 no
GO:1904018 positive regulation of vasculature development 33.3333 5 no
GO:2000209 regulation of anoikis 33.3333 6 no
GO:2000811 negative regulation of anoikis 33.3333 7 no
GO:0002052 positive regulation of neuroblast proliferation 33.3333 7 no
GO:0010720 positive regulation of cell development 33.3333 6 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0050769 positive regulation of neurogenesis 33.3333 6 no
GO:0051960 regulation of nervous system development 33.3333 5 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:1902692 regulation of neuroblast proliferation 33.3333 6 no
GO:2000177 regulation of neural precursor cell proliferation 33.3333 5 no
GO:2000179 positive regulation of neural precursor cell proliferation 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0000302 response to reactive oxygen species 33.3333 4 yes
GO:0002237 response to molecule of bacterial origin 33.3333 4 yes
GO:0002573 myeloid leukocyte differentiation 33.3333 5 yes
GO:0006508 proteolysis 33.3333 4 yes
GO:0006915 apoptotic process 33.3333 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.3333 5 yes
GO:0009411 response to UV 33.3333 5 yes
GO:0010038 response to metal ion 33.3333 4 yes
GO:0010466 negative regulation of peptidase activity 33.3333 6 yes
GO:0010632 regulation of epithelial cell migration 33.3333 4 yes
GO:0010634 positive regulation of epithelial cell migration 33.3333 5 yes
GO:0010638 positive regulation of organelle organization 33.3333 6 yes
GO:0010951 negative regulation of endopeptidase activity 33.3333 7 yes
GO:0022411 cellular component disassembly 33.3333 4 yes
GO:0022617 extracellular matrix disassembly 33.3333 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TIMP1_HUMAN [view interactions] Low throughput no no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
MMP9_HUMAN [view entry] [view interactions] Low throughput yes no
SCUB3_HUMAN [view interactions] Low throughput no no
MEP1A_HUMAN [view interactions] Low throughput no no
MEP1B_HUMAN [view interactions] Low throughput no no
NGAL_HUMAN [view interactions] Low throughput no no
CSPG2_HUMAN [view entry] [view interactions] Low throughput yes no
SRGN_HUMAN [view interactions] Low throughput no no
TGFB1_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
TSP2_HUMAN [view interactions] Low throughput no yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA5_HUMAN [view entry] [view interactions] Low throughput yes no
BGH3_HUMAN [view interactions] Low throughput no no
SMAD3_HUMAN [view interactions] Low throughput no yes
CXCL5_HUMAN [view interactions] Low throughput no yes
CXCL6_HUMAN [view interactions] Low throughput no no
CO2A1_HUMAN [view interactions] High throughput no no
CO4A1_HUMAN [view interactions] High throughput no yes
CO4A2_HUMAN [view interactions] High throughput no no
CO6A1_HUMAN [view interactions] High throughput no no
CO6A2_HUMAN [view interactions] High throughput no no
CO5A1_HUMAN [view interactions] High throughput no no
COIA1_HUMAN [view interactions] High throughput no no
COCA1_HUMAN [view interactions] High throughput no yes
COEA1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
SCAR3_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
FBXW8_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
COL12_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
GLGB_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
EGFL8_HUMAN [view interactions] High throughput no no
CP343_HUMAN [view interactions] High throughput no no
KLK10_HUMAN [view interactions] High throughput no no
SKP2_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
MMP1_HUMAN [view interactions] High throughput no no
MMP11_HUMAN [view interactions] High throughput no no
MMP2_HUMAN [view interactions] High throughput no no
MMP27_HUMAN [view interactions] High throughput no no
MMP3_HUMAN [view interactions] High throughput no no
MMP8_HUMAN [view interactions] High throughput no no
MMP10_HUMAN [view interactions] High throughput no no