Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MMP9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed, PubMed, PubMed). Could play a role in bone osteoclastic resorption . Cleaves KiSS1 at a Gly-|-Leu bond (PubMed). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed). Degrades fibronectin but not laminin or Pz-peptide. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MMP9_HUMAN
GO:0043169 cation binding 83.3333 4 yes
GO:0046872 metal ion binding 83.3333 5 yes
GO:0005509 calcium ion binding 50.0000 6 no
GO:0004175 endopeptidase activity 33.3333 4 yes
GO:0004222 metalloendopeptidase activity 33.3333 5 yes
GO:0004252 serine-type endopeptidase activity 33.3333 5 yes
GO:0008236 serine-type peptidase activity 33.3333 4 yes
GO:0008237 metallopeptidase activity 33.3333 4 yes
GO:0008270 zinc ion binding 33.3333 7 yes
GO:0046914 transition metal ion binding 33.3333 6 yes
GO:0001618 virus receptor activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in MMP9_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0042127 regulation of cell population proliferation 83.3333 4 yes
GO:0042981 regulation of apoptotic process 83.3333 5 yes
GO:0043066 negative regulation of apoptotic process 83.3333 6 yes
GO:0043067 regulation of programmed cell death 83.3333 4 yes
GO:0043069 negative regulation of programmed cell death 83.3333 5 yes
GO:0048523 negative regulation of cellular process 83.3333 4 yes
GO:0048584 positive regulation of response to stimulus 83.3333 4 yes
GO:2000026 regulation of multicellular organismal development 83.3333 4 yes
GO:0009966 regulation of signal transduction 83.3333 4 yes
GO:0009967 positive regulation of signal transduction 83.3333 5 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0010647 positive regulation of cell communication 83.3333 5 yes
GO:0023056 positive regulation of signaling 83.3333 4 yes
GO:0030334 regulation of cell migration 66.6667 5 yes
GO:0030335 positive regulation of cell migration 66.6667 6 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:0040017 positive regulation of locomotion 66.6667 4 yes
GO:0043065 positive regulation of apoptotic process 66.6667 6 yes
GO:0043068 positive regulation of programmed cell death 66.6667 5 yes
GO:0045595 regulation of cell differentiation 66.6667 4 yes
GO:0048585 negative regulation of response to stimulus 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 66.6667 6 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0080134 regulation of response to stress 66.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 yes
GO:1902532 negative regulation of intracellular signal transduction 66.6667 6 yes
GO:2000145 regulation of cell motility 66.6667 4 yes
GO:2000147 positive regulation of cell motility 66.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 66.6667 4 no
GO:0008284 positive regulation of cell population proliferation 66.6667 5 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0009968 negative regulation of signal transduction 66.6667 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0010648 negative regulation of cell communication 66.6667 5 yes
GO:0023057 negative regulation of signaling 66.6667 4 yes
GO:0030162 regulation of proteolysis 50.0000 6 yes
GO:0030198 extracellular matrix organization 50.0000 5 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0031401 positive regulation of protein modification process 50.0000 7 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 50.0000 5 yes
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 50.0000 5 yes
GO:0035987 endodermal cell differentiation 50.0000 4 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0043062 extracellular structure organization 50.0000 4 yes
GO:0043269 regulation of monoatomic ion transport 50.0000 5 yes
GO:0045229 external encapsulating structure organization 50.0000 4 yes
GO:0045596 negative regulation of cell differentiation 50.0000 5 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:0051093 negative regulation of developmental process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 50.0000 6 yes
GO:0051336 regulation of hydrolase activity 50.0000 4 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 50.0000 7 yes
GO:1903131 mononuclear cell differentiation 50.0000 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 50.0000 6 yes
GO:2001233 regulation of apoptotic signaling pathway 50.0000 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 50.0000 6 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 50.0000 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 50.0000 7 yes
GO:2001257 regulation of cation channel activity 50.0000 6 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0001501 skeletal system development 50.0000 4 yes
GO:0001932 regulation of protein phosphorylation 50.0000 7 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0002521 leukocyte differentiation 50.0000 4 yes
GO:0009416 response to light stimulus 50.0000 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010821 regulation of mitochondrion organization 50.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0022898 regulation of transmembrane transporter activity 50.0000 4 yes
GO:0030099 myeloid cell differentiation 33.3333 4 yes
GO:0030225 macrophage differentiation 33.3333 6 yes
GO:0030856 regulation of epithelial cell differentiation 33.3333 5 yes
GO:0030857 negative regulation of epithelial cell differentiation 33.3333 6 yes
GO:0031347 regulation of defense response 33.3333 5 yes
GO:0032092 positive regulation of protein binding 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0032410 negative regulation of transporter activity 33.3333 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 33.3333 5 yes
GO:0032496 response to lipopolysaccharide 33.3333 4 yes
GO:0033993 response to lipid 33.3333 4 yes
GO:0034599 cellular response to oxidative stress 33.3333 4 yes
GO:0034614 cellular response to reactive oxygen species 33.3333 5 yes
GO:0034644 cellular response to UV 33.3333 6 yes
GO:0034763 negative regulation of transmembrane transport 33.3333 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 33.3333 6 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 33.3333 6 yes
GO:0043086 negative regulation of catalytic activity 33.3333 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 7 yes
GO:0043271 negative regulation of monoatomic ion transport 33.3333 5 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 8 yes
GO:0043388 positive regulation of DNA binding 33.3333 5 yes
GO:0043393 regulation of protein binding 33.3333 4 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 33.3333 7 yes
GO:0045861 negative regulation of proteolysis 33.3333 7 yes
GO:0046686 response to cadmium ion 33.3333 5 yes
GO:0048013 ephrin receptor signaling pathway 33.3333 6 yes
GO:0048660 regulation of smooth muscle cell proliferation 33.3333 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 33.3333 6 yes
GO:0050727 regulation of inflammatory response 33.3333 5 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051099 positive regulation of binding 33.3333 4 yes
GO:0051101 regulation of DNA binding 33.3333 4 yes
GO:0051346 negative regulation of hydrolase activity 33.3333 5 yes
GO:0051547 regulation of keratinocyte migration 33.3333 5 yes
GO:0051549 positive regulation of keratinocyte migration 33.3333 6 yes
GO:0052547 regulation of peptidase activity 33.3333 5 yes
GO:0052548 regulation of endopeptidase activity 33.3333 6 yes
GO:0062197 cellular response to chemical stress 33.3333 4 yes
GO:0070141 response to UV-A 33.3333 6 yes
GO:0071219 cellular response to molecule of bacterial origin 33.3333 4 yes
GO:0071222 cellular response to lipopolysaccharide 33.3333 5 yes
GO:0071241 cellular response to inorganic substance 33.3333 4 yes
GO:0071248 cellular response to metal ion 33.3333 5 yes
GO:0071276 cellular response to cadmium ion 33.3333 6 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0071396 cellular response to lipid 33.3333 5 yes
GO:0071478 cellular response to radiation 33.3333 4 yes
GO:0071482 cellular response to light stimulus 33.3333 5 yes
GO:0071492 cellular response to UV-A 33.3333 7 yes
GO:0090200 positive regulation of release of cytochrome c from mitochondria 33.3333 7 yes
GO:0150077 regulation of neuroinflammatory response 33.3333 6 yes
GO:1900120 regulation of receptor binding 33.3333 5 yes
GO:1900122 positive regulation of receptor binding 33.3333 6 yes
GO:1901184 regulation of ERBB signaling pathway 33.3333 5 yes
GO:1901186 positive regulation of ERBB signaling pathway 33.3333 6 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 yes
GO:1904063 negative regulation of cation transmembrane transport 33.3333 7 yes
GO:1904645 response to amyloid-beta 33.3333 4 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 33.3333 6 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 33.3333 7 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 33.3333 8 yes
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 33.3333 6 yes
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development 33.3333 7 yes
GO:2001258 negative regulation of cation channel activity 33.3333 6 yes
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 33.3333 9 yes
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 33.3333 7 yes
GO:0007159 leukocyte cell-cell adhesion 33.3333 4 no
GO:0007160 cell-matrix adhesion 33.3333 4 no
GO:0007229 integrin-mediated signaling pathway 33.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0023035 CD40 signaling pathway 33.3333 4 no
GO:0033631 cell-cell adhesion mediated by integrin 33.3333 4 no
GO:0034113 heterotypic cell-cell adhesion 33.3333 4 no
GO:0035313 wound healing, spreading of epidermal cells 33.3333 5 no
GO:0044319 wound healing, spreading of cells 33.3333 4 no
GO:0045765 regulation of angiogenesis 33.3333 5 no
GO:0045766 positive regulation of angiogenesis 33.3333 6 no
GO:0050890 cognition 33.3333 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 33.3333 4 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 no
GO:1901342 regulation of vasculature development 33.3333 5 no
GO:1904018 positive regulation of vasculature development 33.3333 5 no
GO:2000209 regulation of anoikis 33.3333 6 no
GO:2000811 negative regulation of anoikis 33.3333 7 no
GO:0002052 positive regulation of neuroblast proliferation 33.3333 7 no
GO:0010720 positive regulation of cell development 33.3333 6 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0050769 positive regulation of neurogenesis 33.3333 6 no
GO:0051960 regulation of nervous system development 33.3333 5 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:1902692 regulation of neuroblast proliferation 33.3333 6 no
GO:2000177 regulation of neural precursor cell proliferation 33.3333 5 no
GO:2000179 positive regulation of neural precursor cell proliferation 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0000302 response to reactive oxygen species 33.3333 4 yes
GO:0002237 response to molecule of bacterial origin 33.3333 4 yes
GO:0002573 myeloid leukocyte differentiation 33.3333 5 yes
GO:0006508 proteolysis 33.3333 4 yes
GO:0006915 apoptotic process 33.3333 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.3333 5 yes
GO:0009411 response to UV 33.3333 5 yes
GO:0010038 response to metal ion 33.3333 4 yes
GO:0010466 negative regulation of peptidase activity 33.3333 6 yes
GO:0010632 regulation of epithelial cell migration 33.3333 4 yes
GO:0010634 positive regulation of epithelial cell migration 33.3333 5 yes
GO:0010638 positive regulation of organelle organization 33.3333 6 yes
GO:0010951 negative regulation of endopeptidase activity 33.3333 7 yes
GO:0022411 cellular component disassembly 33.3333 4 yes
GO:0022617 extracellular matrix disassembly 33.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TIMP1_HUMAN [view interactions] Low throughput no no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
MMP9_HUMAN [view entry] [view interactions] Low throughput yes no
SCUB3_HUMAN [view interactions] Low throughput no no
MEP1A_HUMAN [view interactions] Low throughput no no
MEP1B_HUMAN [view interactions] Low throughput no no
NGAL_HUMAN [view interactions] Low throughput no no
CSPG2_HUMAN [view entry] [view interactions] Low throughput yes no
SRGN_HUMAN [view interactions] Low throughput no no
TGFB1_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
TSP2_HUMAN [view interactions] Low throughput no yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA5_HUMAN [view entry] [view interactions] Low throughput yes no
BGH3_HUMAN [view interactions] Low throughput no no
SMAD3_HUMAN [view interactions] Low throughput no yes
CXCL5_HUMAN [view interactions] Low throughput no yes
CXCL6_HUMAN [view interactions] Low throughput no no
CO2A1_HUMAN [view interactions] High throughput no no
CO4A1_HUMAN [view interactions] High throughput no yes
CO4A2_HUMAN [view interactions] High throughput no no
CO6A1_HUMAN [view interactions] High throughput no no
CO6A2_HUMAN [view interactions] High throughput no no
CO5A1_HUMAN [view interactions] High throughput no no
COIA1_HUMAN [view interactions] High throughput no no
COCA1_HUMAN [view interactions] High throughput no yes
COEA1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
SCAR3_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
FBXW8_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
COL12_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
GLGB_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
EGFL8_HUMAN [view interactions] High throughput no no
CP343_HUMAN [view interactions] High throughput no no
KLK10_HUMAN [view interactions] High throughput no no
SKP2_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
MMP1_HUMAN [view interactions] High throughput no no
MMP11_HUMAN [view interactions] High throughput no no
MMP2_HUMAN [view interactions] High throughput no no
MMP27_HUMAN [view interactions] High throughput no no
MMP3_HUMAN [view interactions] High throughput no no
MMP8_HUMAN [view interactions] High throughput no no
MMP10_HUMAN [view interactions] High throughput no no