TFR2_HUMAN
Evidence for PS localization
Functions
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 172 | Met | Lys | Hemochromatosis3(HFE3) | - |
| 22 | Val | Ile | Hemochromatosis3(HFE3) | - |
| 690 | Gln | Pro | Hemochromatosis3(HFE3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TFR2_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 40.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 40.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TFR2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | yes |
| GO:0030001 | metal ion transport | 40.0000 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 40.0000 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 40.0000 | 4 | yes |
| GO:0048878 | chemical homeostasis | 40.0000 | 4 | yes |
| GO:0050801 | ion homeostasis | 40.0000 | 5 | yes |
| GO:0051046 | regulation of secretion | 40.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 40.0000 | 7 | yes |
| GO:0055080 | cation homeostasis | 40.0000 | 6 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | yes |
| GO:0090087 | regulation of peptide transport | 40.0000 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 40.0000 | 5 | yes |
| GO:0098657 | import into cell | 40.0000 | 4 | yes |
| GO:0098771 | inorganic ion homeostasis | 40.0000 | 6 | yes |
| GO:1903317 | regulation of protein maturation | 40.0000 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 40.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0002791 | regulation of peptide secretion | 40.0000 | 6 | yes |
| GO:0006811 | ion transport | 40.0000 | 4 | yes |
| GO:0006812 | cation transport | 40.0000 | 5 | yes |
| GO:0006873 | cellular ion homeostasis | 40.0000 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 40.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYCP3_HUMAN | [view interactions] | Low throughput | no | no |
| CD81_HUMAN | [view interactions] | Low throughput | no | no |
| TINF2_HUMAN | [view interactions] | Low throughput | no | no |
| DCR1B_HUMAN | [view interactions] | Low throughput | no | no |
| TRFE_HUMAN | [view interactions] | Low throughput | no | no |
| SOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| OLFM4_HUMAN | [view interactions] | High throughput | no | no |
| SC22A_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| TAF5L_HUMAN | [view interactions] | High throughput | no | no |
| GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RPP29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| EPOR_HUMAN | [view interactions] | Computational | no | no |
| BMP6_HUMAN | [view interactions] | Computational | no | no |
| TMPS6_HUMAN | [view interactions] | Computational | no | no |
| HEPC_HUMAN | [view interactions] | Computational | no | no |
| RGMC_HUMAN | [view interactions] | Computational | no | no |
| S40A1_HUMAN | [view interactions] | Computational | no | no |
| HFE_HUMAN | [view interactions] | Computational | no | yes |