Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MOT4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004276 TRG_DiLeu_BaEn_2 TRG 441 447 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MOT4_HUMAN
GO:0017076 purine nucleotide binding 57.1429 4 no
GO:0032555 purine ribonucleotide binding 57.1429 4 no
GO:0035639 purine ribonucleoside triphosphate binding 57.1429 4 no
GO:0019900 kinase binding 52.3810 4 no
GO:0019901 protein kinase binding 47.6190 5 no
GO:0003924 GTPase activity 38.0952 7 no
GO:0005525 GTP binding 38.0952 5 no
GO:0016462 pyrophosphatase activity 38.0952 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 38.0952 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 38.0952 6 no
GO:0019001 guanyl nucleotide binding 38.0952 5 no
GO:0032561 guanyl ribonucleotide binding 38.0952 5 no
GO:0003723 RNA binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MOT4_HUMAN
GO:0048522 positive regulation of cellular process 80.9524 4 no
GO:0051128 regulation of cellular component organization 71.4286 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0033043 regulation of organelle organization 61.9048 5 no
GO:0060255 regulation of macromolecule metabolic process 61.9048 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0051493 regulation of cytoskeleton organization 57.1429 6 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0009893 positive regulation of metabolic process 52.3810 4 no
GO:0010468 regulation of gene expression 52.3810 5 no
GO:0010604 positive regulation of macromolecule metabolic process 52.3810 5 no
GO:0010646 regulation of cell communication 52.3810 4 no
GO:0032956 regulation of actin cytoskeleton organization 52.3810 5 no
GO:0032970 regulation of actin filament-based process 52.3810 4 no
GO:0051049 regulation of transport 52.3810 4 no
GO:0006996 organelle organization 47.6190 4 no
GO:0007010 cytoskeleton organization 47.6190 5 no
GO:0009966 regulation of signal transduction 47.6190 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.6190 5 no
GO:0022603 regulation of anatomical structure morphogenesis 47.6190 4 no
GO:0030030 cell projection organization 47.6190 4 no
GO:0031325 positive regulation of cellular metabolic process 47.6190 5 no
GO:0060341 regulation of cellular localization 47.6190 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0030334 regulation of cell migration 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0042127 regulation of cell population proliferation 42.8571 4 no
GO:0043085 positive regulation of catalytic activity 42.8571 4 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.8571 5 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:2000145 regulation of cell motility 42.8571 4 no
GO:0032880 regulation of protein localization 42.8571 5 no
GO:1903829 positive regulation of protein localization 42.8571 5 no
GO:0007015 actin filament organization 38.0952 5 no
GO:0007264 small GTPase mediated signal transduction 38.0952 4 no
GO:0019220 regulation of phosphate metabolic process 38.0952 6 no
GO:0022604 regulation of cell morphogenesis 38.0952 5 no
GO:0023056 positive regulation of signaling 38.0952 4 no
GO:0030155 regulation of cell adhesion 38.0952 4 no
GO:0031344 regulation of cell projection organization 38.0952 5 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0051130 positive regulation of cellular component organization 38.0952 5 no
GO:0051174 regulation of phosphorus metabolic process 38.0952 5 no
GO:0051252 regulation of RNA metabolic process 38.0952 5 no
GO:0051726 regulation of cell cycle 38.0952 4 no
GO:0097435 supramolecular fiber organization 38.0952 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.0952 6 no
GO:0031175 neuron projection development 38.0952 6 no
GO:0120036 plasma membrane bounded cell projection organization 38.0952 5 no
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0008360 regulation of cell shape 33.3333 6 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0030865 cortical cytoskeleton organization 33.3333 6 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0002009 morphogenesis of an epithelium 28.5714 4 no
GO:0008285 negative regulation of cell population proliferation 28.5714 5 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0051495 positive regulation of cytoskeleton organization 28.5714 7 no
GO:0061024 membrane organization 28.5714 4 no
GO:0110053 regulation of actin filament organization 28.5714 6 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:1902903 regulation of supramolecular fiber organization 28.5714 5 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0032386 regulation of intracellular transport 28.5714 5 no
GO:0051222 positive regulation of protein transport 28.5714 5 no
GO:0051223 regulation of protein transport 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:1904951 positive regulation of establishment of protein localization 28.5714 6 no
GO:0008104 protein localization 28.5714 4 no
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0009891 positive regulation of biosynthetic process 23.8095 5 no
GO:0010324 membrane invagination 23.8095 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0010564 regulation of cell cycle process 23.8095 5 no
GO:0010628 positive regulation of gene expression 23.8095 6 no
GO:0010810 regulation of cell-substrate adhesion 23.8095 5 no
GO:0010941 regulation of cell death 23.8095 4 no
GO:0031328 positive regulation of cellular biosynthetic process 23.8095 6 no
GO:0042981 regulation of apoptotic process 23.8095 6 no
GO:0043067 regulation of programmed cell death 23.8095 5 no
GO:0043254 regulation of protein-containing complex assembly 23.8095 5 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0045597 positive regulation of cell differentiation 23.8095 5 no
GO:0045859 regulation of protein kinase activity 23.8095 6 no
GO:0045860 positive regulation of protein kinase activity 23.8095 7 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0051345 positive regulation of hydrolase activity 23.8095 5 no
GO:0099024 plasma membrane invagination 23.8095 6 no
GO:1902905 positive regulation of supramolecular fiber organization 23.8095 6 no
GO:0016192 vesicle-mediated transport 23.8095 4 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:0030031 cell projection assembly 23.8095 5 no
GO:0031346 positive regulation of cell projection organization 23.8095 6 no
GO:0032388 positive regulation of intracellular transport 23.8095 5 no
GO:0033157 regulation of intracellular protein transport 23.8095 6 no
GO:0060491 regulation of cell projection assembly 23.8095 5 no
GO:0090316 positive regulation of intracellular protein transport 23.8095 6 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 23.8095 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.8095 6 no
GO:1905475 regulation of protein localization to membrane 23.8095 6 no
GO:1905477 positive regulation of protein localization to membrane 23.8095 6 no
GO:0071702 organic substance transport 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CD44_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
NEDD1_HUMAN [view interactions] High throughput no yes
NFYA_HUMAN [view interactions] High throughput no yes
TSNAX_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
FAM9B_HUMAN [view interactions] High throughput no no
BANP_HUMAN [view interactions] High throughput no yes
NR2CA_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
HPCA_HUMAN [view entry] [view interactions] High throughput yes yes
CXA8_HUMAN [view interactions] High throughput no no
S15A4_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC7_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
NPC1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
EMB_HUMAN [view interactions] Computational no no
HAKAI_HUMAN [view interactions] Computational no yes
BASI_HUMAN [view entry] [view interactions] Computational yes no