DGLB_HUMAN
Evidence for PS localization
Functions
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DGLB_HUMAN |
|---|---|---|---|---|
| GO:0016298 | lipase activity | 57.1429 | 4 | yes |
| GO:0047372 | acylglycerol lipase activity | 57.1429 | 5 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 57.1429 | 4 | yes |
| GO:0046872 | metal ion binding | 42.8571 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DGLB_HUMAN |
|---|---|---|---|---|
| GO:0001676 | long-chain fatty acid metabolic process | 57.1429 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 57.1429 | 4 | yes |
| GO:0006690 | icosanoid metabolic process | 57.1429 | 6 | yes |
| GO:0016042 | lipid catabolic process | 57.1429 | 4 | yes |
| GO:0019369 | arachidonic acid metabolic process | 57.1429 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 57.1429 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 57.1429 | 6 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 57.1429 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 57.1429 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 42.8571 | 4 | yes |
| GO:0080134 | regulation of response to stress | 42.8571 | 4 | yes |
| GO:0006638 | neutral lipid metabolic process | 42.8571 | 4 | no |
| GO:0006639 | acylglycerol metabolic process | 42.8571 | 5 | no |
| GO:0044242 | cellular lipid catabolic process | 42.8571 | 4 | no |
| GO:0046461 | neutral lipid catabolic process | 42.8571 | 5 | no |
| GO:0046464 | acylglycerol catabolic process | 42.8571 | 6 | no |
| GO:0046486 | glycerolipid metabolic process | 42.8571 | 4 | no |
| GO:0046503 | glycerolipid catabolic process | 42.8571 | 5 | no |
| GO:0007215 | glutamate receptor signaling pathway | 28.5714 | 4 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 28.5714 | 4 | yes |
| GO:0007405 | neuroblast proliferation | 28.5714 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | yes |
| GO:0019216 | regulation of lipid metabolic process | 28.5714 | 5 | yes |
| GO:0022008 | neurogenesis | 28.5714 | 4 | yes |
| GO:0031347 | regulation of defense response | 28.5714 | 5 | yes |
| GO:0038171 | cannabinoid signaling pathway | 28.5714 | 4 | yes |
| GO:0042136 | neurotransmitter biosynthetic process | 28.5714 | 4 | yes |
| GO:0045834 | positive regulation of lipid metabolic process | 28.5714 | 5 | yes |
| GO:0050727 | regulation of inflammatory response | 28.5714 | 5 | yes |
| GO:0071926 | endocannabinoid signaling pathway | 28.5714 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | yes |
| GO:0098917 | retrograde trans-synaptic signaling | 28.5714 | 5 | yes |
| GO:0098920 | retrograde trans-synaptic signaling by lipid | 28.5714 | 6 | yes |
| GO:0098921 | retrograde trans-synaptic signaling by endocannabinoid | 28.5714 | 7 | yes |
| GO:0099537 | trans-synaptic signaling | 28.5714 | 4 | yes |
| GO:0099541 | trans-synaptic signaling by lipid | 28.5714 | 5 | yes |
| GO:0099542 | trans-synaptic signaling by endocannabinoid | 28.5714 | 6 | yes |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0030334 | regulation of cell migration | 28.5714 | 5 | no |
| GO:0046462 | monoacylglycerol metabolic process | 28.5714 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 28.5714 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0052651 | monoacylglycerol catabolic process | 28.5714 | 7 | no |
| GO:2000145 | regulation of cell motility | 28.5714 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NC_HUMAN | [view interactions] | High throughput | no | no |
| CLP1_HUMAN | [view interactions] | High throughput | no | yes |
| PISD_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| SGCZ_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| SLAF7_HUMAN | [view interactions] | High throughput | no | no |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| PCDC2_HUMAN | [view interactions] | High throughput | no | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDG5_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGG_HUMAN | [view interactions] | High throughput | no | no |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| ENTP7_HUMAN | [view interactions] | High throughput | no | no |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SFT2A_HUMAN | [view interactions] | High throughput | no | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TSN31_HUMAN | [view interactions] | High throughput | no | yes |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| EDAR_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| LRC55_HUMAN | [view interactions] | High throughput | no | yes |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| ACV1C_HUMAN | [view interactions] | High throughput | no | yes |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| O10H2_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| FAAH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DGLA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABHD6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NAPEP_HUMAN | [view interactions] | Computational | no | yes |