TTC37_HUMAN
Evidence for PS localization
Functions
Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 251 | Gly | Arg | Trichohepatoentericsyndrome1(THES1) | - |
| 1283 | Asp | Asn | Trichohepatoentericsyndrome1(THES1) | - |
| 1505 | Leu | Ser | Trichohepatoentericsyndrome1(THES1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TTC37_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 52.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TTC37_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 36.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 28.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 28.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 28.0000 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 24.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0008104 | protein localization | 24.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 24.0000 | 5 | no |
| GO:0016070 | RNA metabolic process | 16.0000 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 12.0000 | 4 | yes |
| GO:0010629 | negative regulation of gene expression | 12.0000 | 6 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 12.0000 | 4 | yes |
| GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic | 8.0000 | 8 | yes |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | 8.0000 | 7 | yes |
| GO:0006401 | RNA catabolic process | 8.0000 | 5 | yes |
| GO:0006402 | mRNA catabolic process | 8.0000 | 6 | yes |
| GO:0016071 | mRNA metabolic process | 8.0000 | 6 | yes |
| GO:0019439 | aromatic compound catabolic process | 8.0000 | 4 | yes |
| GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | 8.0000 | 9 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 8.0000 | 4 | yes |
| GO:0044270 | cellular nitrogen compound catabolic process | 8.0000 | 4 | yes |
| GO:0046700 | heterocycle catabolic process | 8.0000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 8.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR61_HUMAN | [view interactions] | Low throughput | no | yes |
| PAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SKIV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| TTC33_HUMAN | [view interactions] | High throughput | no | yes |
| PHF5A_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| DHDH_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS4_HUMAN | [view interactions] | High throughput | no | yes |
| FERM1_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| CRYL1_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD6_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS3_HUMAN | [view interactions] | Computational | no | yes |
| HBS1L_HUMAN | [view interactions] | Computational | no | yes |
| EXOS9_HUMAN | [view interactions] | Computational | no | yes |
| EXOS6_HUMAN | [view interactions] | Computational | no | no |
| XRN1_HUMAN | [view interactions] | Computational | no | yes |
| EXOS8_HUMAN | [view interactions] | Computational | no | yes |
| EXOSX_HUMAN | [view interactions] | Computational | no | yes |
| EXOS1_HUMAN | [view interactions] | Computational | no | yes |
| EXOS5_HUMAN | [view interactions] | Computational | no | yes |
| MTREX_HUMAN | [view interactions] | Computational | no | yes |
| EXOS7_HUMAN | [view interactions] | Computational | no | yes |
| RRP44_HUMAN | [view interactions] | Computational | no | yes |