KGD4_HUMAN
Evidence for PS localization
Functions
May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KGD4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 48.1481 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.9259 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.9259 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.9259 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.9259 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 25.9259 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.9259 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KGD4_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 40.7407 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 40.7407 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.0370 | 4 | no |
| GO:0006996 | organelle organization | 29.6296 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.9259 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.9259 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.9259 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.2222 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 22.2222 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.2222 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 22.2222 | 4 | no |
| GO:0043648 | dicarboxylic acid metabolic process | 18.5185 | 6 | yes |
| GO:0006103 | 2-oxoglutarate metabolic process | 14.8148 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KGD4_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 7.4074 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT252_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| TCAIM_HUMAN | [view interactions] | High throughput | no | no |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
| THEM5_HUMAN | [view interactions] | High throughput | no | no |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| RPAB4_HUMAN | [view interactions] | High throughput | no | no |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| RM18_HUMAN | [view interactions] | High throughput | no | yes |
| RM33_HUMAN | [view interactions] | High throughput | no | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM32_HUMAN | [view interactions] | High throughput | no | yes |
| RM40_HUMAN | [view interactions] | High throughput | no | yes |
| RM45_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| RM09_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| RM19_HUMAN | [view interactions] | High throughput | no | yes |
| RM02_HUMAN | [view interactions] | High throughput | no | yes |
| RM39_HUMAN | [view interactions] | High throughput | no | yes |
| RM46_HUMAN | [view interactions] | High throughput | no | yes |
| RT30_HUMAN | [view interactions] | High throughput | no | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| RM34_HUMAN | [view interactions] | High throughput | no | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| RM48_HUMAN | [view interactions] | High throughput | no | yes |
| RT18A_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| FMT_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| NGRN_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT31_HUMAN | [view interactions] | Computational | no | yes |
| RT09_HUMAN | [view interactions] | Computational | no | yes |
| RT22_HUMAN | [view interactions] | Computational | no | yes |
| RT17_HUMAN | [view interactions] | Computational | no | yes |
| ERAL1_HUMAN | [view interactions] | Computational | no | yes |
| PTCD3_HUMAN | [view interactions] | Computational | no | yes |
| RT06_HUMAN | [view interactions] | Computational | no | yes |
| RT29_HUMAN | [view interactions] | Computational | no | yes |
| RT33_HUMAN | [view interactions] | Computational | no | no |
| RM42_HUMAN | [view interactions] | Computational | no | yes |
| RT23_HUMAN | [view interactions] | Computational | no | yes |
| RT35_HUMAN | [view interactions] | Computational | no | yes |
| RT28_HUMAN | [view interactions] | Computational | no | yes |
| RT11_HUMAN | [view interactions] | Computational | no | yes |
| RT24_HUMAN | [view interactions] | Computational | no | yes |
| RT25_HUMAN | [view interactions] | Computational | no | yes |
| RT15_HUMAN | [view interactions] | Computational | no | yes |
| RT05_HUMAN | [view interactions] | Computational | no | yes |
| RT27_HUMAN | [view interactions] | Computational | no | yes |
| RT07_HUMAN | [view interactions] | Computational | no | yes |
| RT18C_HUMAN | [view interactions] | Computational | no | yes |
| RT18B_HUMAN | [view interactions] | Computational | no | yes |
| RT14_HUMAN | [view interactions] | Computational | no | yes |
| RT16_HUMAN | [view interactions] | Computational | no | yes |
| RT21_HUMAN | [view interactions] | Computational | no | no |
| RT10_HUMAN | [view interactions] | Computational | no | yes |